Technology of rotary Inconel element manufacturing in Frencken Brno

Je zpracováván postup výroby rotačního dílu v podmínkách firmy Frencken Brno. V první části je představena firma a její zázemí, popsán funkční princip stroje a detaily jeho programování. Jsou popsány základní vlastnosti obráběného materiálu Inconel. V druhé části je obsažen postup výroby a volba nástrojové sady. V závěru jsou vysvětleny stěžejní části NC programu.Elaborates process of manufacturing rotary element in Frencken Brno. In the first part are introduced the company and it´s production equipment, described functional principle of machine and programming details. Discussed the basic features of Inconel material. The second part contains manufacturing process and choice of the tool set. Main parts of NC program are described in the end.

Productive Machining of Titanium Alloys

Diplomová práce je zaměřena na produktivní obrábění titanových slitin. Na začátku pojednává o titanu a jeho slitinách. Popisuje mechanismus tvorby třísky, opotřebení nástrojů a kvalitu obrobené plochy. Dále obsahuje moderní strategie efektivního obrábění titanových slitin. Poté analyzuje současnou technologii výroby závěsu vyrobeného z titanové slitiny Ti-6Al-4V ve společnosti Frentech Aerospace s.r.o. a ve svém závěru nachází možnost úspor v inovaci hrubovacího procesu.This diploma thesis is focused on a productive machining of titanium alloys. At the beginning it deals about titanium and its alloys. It describes chip generation mechanism, tool blunting and surface quality. Further it contains modern strategies of efficient titanium alloys machining. Then it analyzes contemporary manufacturing technology of hinge made of titanium alloy Ti-6Al-4V in Frentech Aerospace s.r.o. company, and at the end finds possibility of savings by inovation of roughing process.

MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice

Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation remains one of the last options for patients with terminal refractory heart failure. Besides the infectious or oncological complications, the prognosis of patients after heart transplantation is affected by acute cellular or antibody-mediated rejection and allograft vasculopathy development. Current monitoring of both conditions requires the performance of invasive procedures (endomyocardial biopsy sampling and coronary angiography or optical coherence tomography, respectively) that are costly, time-demanding, and non-comfortable for the patient. Within this narrative review, we focus on the potential pathophysiological and clinical roles of microRNAs (miRNAs, miRs) in the field of cardiac allograft transplantation. Firstly, we provide a general introduction about the status of cardiac allograft function monitoring and the discovery of miRNAs as post-transcriptional regulators of gene expression and clinically relevant biomarkers found in the extracellular fluid. After this general introduction, information from animal and human studies are summarized to underline the importance of miRNAs both in the pathophysiology of the rejection process, the possibility of its modulation by altering miRNAs levels, and last but not least, about the use of miRNAs in the clinical practice to diagnose or predict the rejection occurrence

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe

The use of social networks of youth in a leisure time

This bachelor thesis deals with the issue of using social networks in the leisure time of young people. The main goal of the work is to find out how young people use social networks in their free time. Other sub-objectives were to find out how young people spend their free time, how they perceive space on social networks and whether the use of social networks can have a negative effect on the adolescent. In the theoretical part we will try to define the terms with which we will continue to work in the practical part. In the first chapter we will explain the concept of leisure time and its appreciation, and we will also define the concept of youth. In the next chapter we will deal with social networks. We will address the specifics of the virtual environment, define what a virtual identity is and also focus on the mental health of young people in the context of using social networks. In the practical part we will clarify the goals of the research and the methods we will proceed in investigating the research problem. We analyze the research results and evaluate the findings

Finanční analýza společnosti Zentiva, a.s.

V rámci analýzy je zhodnocena finanční kondice společnosti Zentiva, a.s. v letech 2002 až 2005. Práce používá standardní analytické postupy jako například horizontální a vertikální analýzu účetních výkazů, analýzu pracovního kapitálu, analýzu poměrových ukazatelů, paralelních soustav ukazatelů a jiné. S pomocí výstupů těchto dílčích analýz dochází k identifikaci a zhodnocení jednotlivých oblastí fungování podniku a vyvození příslušných závěrů o stavu zkoumaného subjektu

The analysis of availability of the social infrastructure in the city of Beroun in the context of the residential suburbanization

Bakalářská práce se zabývá dopady suburbanizačních procesů na zasažené města a obce v zázemí jádrových měst. Konkrétně se zabývá vlivem těchto procesů na sociální infrastrukturu v zasažených městech a obcích. Práce se zaměřuje na město Beroun, které se nachází v okrese Beroun ve Středočeském kraji. Změny v demografické struktuře populace vytvářejí tlak kromě předškolních zařízení a základních škol také na zařízení sociální péče, které poskytují služby mířené na seniory.This bachelor thesis deals with the impact of suburbanization on affected cities and municipalities in the hinterland of core cities. It deals concretely with the influence of the suburbanization on social infrastructure in affected towns and municipalities. The thesis focuses on the city of Beroun, which is located in the district of Beroun in Central Bohemia. The changes in demographic structure of the population put pressure, not only on kindergartens and elementary schools, but also on the social service facilities which take care of pensioners and the elderly

Comparison of the approach of municipalities to waste management from the viewpoint of financing effectivity

This master thesis deals with financial effectivity of financing the collection and disposal of municipal waste in selected municipality. For this purpose, the thesis compares the municipalities of Beroun and Poděbrady, which uses different methods of providing this service. The selected municipalities are compared on basis of set indicators, such as cost per inhabitant or per amount of municipal waste produced.Diplomová práce se zabývá finanční efektivitou financování svozu a likvidace komunálního odpadu ve sledovaných obcích. Práce pro tento účel porovnává obce Beroun a Poděbrady, které využívají odlišné způsoby zajištění této služby. Sledovaná města jsou porovnána na základě stanovených ukazatelů, jako jsou náklady v přepočtu na obyvatele, nebo množství vyprodukovaného komunálního odpadu

Appraisement of enterprise value

The purpose of this text is to estimate the value of Plzeňský Prazdroj, a.s. in order to determine value for yet unknown buyer. Approaches commonly used for appraisement of enterprises' value are used within the text, such as strategic analysis, financial analysis, finacial plan composition and the use of discounted cash flow methods. This thesis results in an appraisement of value of firm's equity on the date of evaluation