Leiomyomatosis peritonealis disseminata in a Nigerian woman

Leiomyomatosis peritonealis disseminata (LPD) is a rare condition. A 48‑year‑old multiparous woman was referred because of an incidental ultrasound finding suggestive of LPD. She had a 6‑year past history of use of combined oral contraceptive pills. LPD was also suspected at laparotomy and confirmed by histology. She had total abdominal hysterectomy, bilateral salpingo ophorectomy and infracolic omentectomy. Patient was being followed‑up. LSD is a rare gynecological condition which can pose a diagnostic challenge. Removal of estrogen sources as was done for the patient is the mainstay of treatment. Patient follow‑up is very important because of the risk of malignant transformation.Keywords: Laparatomy, leiomyoma, leiomyomatosis peritonealis disseminata, Nigeria, ophorectomyNigerian Medical Journal | Vol. 53 | Issue 3 | July-September | 201

Large Symptomatic Chorioangioma of Placenta; A Rare Complication of Pregnancy in Enugu, South East Nigeria

Chorioangioma is the most common non trophoblastic tumour of the placenta which can result to severe pregnancy complications with attendant maternal and fetal morbidity and mortality [1]. Most cases of chorioangiomas are small, microscopic and of no clinical important [2,3]. We present the very first case of large symptomatic chorioangioma managed successfully in University of Nigeria Teaching Hospital Enugu.&nbsp;The patient was referred to the University of Nigeria Teaching Hospital Enugu on account of suspected symptomatic chorioangioma, at a gestational age of 32 weeks. She was managed conservatively and had elective caesarean section at 36 weeks’ gestation with good outcome. There was a large solid and cystic lesion on the placenta measuring 8cm x10cm. Histological diagnosis of chorioangioma of capillary type was made.</p

Transcriptomics analysis reveals unique immunoinflammatory signatures of nigerian prostate cancer

Background: Prostate cancer (PCa) is the leading cause of cancer death among Nigerian men, with most men presenting late and with high grade disease. Furthermore, improved PCa diagnosis and treatment could rely on genomics-driven precision approaches. Mounting evidence supports potential population enriched molecular features of cancer, however the extent of which is hampered due to a dearth of genomic data in diverse cohorts. This study, therefore, aims at utilizing transcriptomics analysis to deduce transcriptional states in PCa from Nigerian men. Methodology: RNA was extracted from macro-dissected prostate tumor and adjacent normal tissue from 35 archival formalin fixed paraffin-embedded (FFPE) blocks from Gleason 8-9 cancers, of which 25 had cribriform morphologic architecture. High resolution hybrid-capture mRNA-seq libraries were sequenced using Illumina NovaSeq 6000 system and generated an average of 124 million read pairs per sample. Raw reads were processed using a custom pipeline based upon industry standard algorithms along with the deduction of genetic ancestry. Molecular annotation was also performed to investigate tumor and immune cell heterogeneity. Result: The Nigerian data were compared with high grade PCa data of Caucasian obtained from TCGA. The Nigerian PCa tumors where characterized with uniquely enriched immune-inflammatory microenvironment which include crosstalk between dendritic cells and natural killer cells, and natural killer cell signaling. While the Nigerian tumors share more features of distal metastatic tumor, their enrichment in NKT Cells is a unique feature. Conclusion: This represents the first report of RNA-seq analysis of PCa in Sub-Saharan Africa and the unique transcriptomics features of Nigerian PCa presents opportunities for precision intervention in addressing its burden in Nigeria