Selected genetic factors increasing risk of neoplasia

Introduction: Neoplasia is defined as abnormal and excessive growth of selected tissue. Several factors, such as mutations in selected genes, can increase the risk of cancer expansion in human body. The aim of the article is to review the selected genetic factors which increase the risk of neoplasia and results of their presence in the human body. Material and methods: Articles in the Google Scholar, Pub Med database have been analysed using keywords: cancer, neoplasia, genetic factors, driver genes, cancer transformation, older people. Results: The aim of several genes is repairing damaged or dysfunctional DNA and preventing cells from abnormal or excessive. Mutations in selected genes cause inhibited production of the gene protein product or a change in its function, which increase the risk of neoplasia. The presence of mutated genes results in the initiation of the process leading to expansion of cancer cells in selected tissue. Moreover, a genetic mutation can lead to syndrome of tumors occurring in several organs. However, the increasement of cancer risk is related to numerous mutations, whereas the minority of carcinomas occur because of congenital gene defect and the majority is caused by environmental factors which contribute to creating various mutations. Conclusions: Thanks to the development of genetics in the field of medicine and introduction of genetic tests, the process of diagnosis of several tumors and syndromes is more efficient than in the past. The occurrence of mutation in genes, such as BRCA1, BRCA2, VHL, MSH2 and MLH1 and many more, relates to presence of selected tumors. By the introduction of pharmacogenetics, dozens of molecular-targeted drugs are used in the treatment of several types of cancers leading the achievement of therapeutic success. Nevertheless, the genetic background of many types of cancers is unknown and needs further study, as well as drugs targeting at selected genes mutations requires more development and guidelines in the treatment process. Keywords: cancer; neoplasia; genetic factors; driver genes; cancer transformation; older people

Rehabilitation in scoliosis - an overview of the most important procedures

Introduction: Scoliosis is defined as deformation of the spine and torso in three dimensions. Study show that scoliosis affects 68% of healthy individuals over 65 years of age with no low back pain. The aim of this article is to review the available scoliosis rehabilitation methods, including the newest physical rehabilitation trends. Material and methods: Articles in the Google Scholar, Pub Med database have been analysed using keywords: scoliosis, deformation of the spine and torso, modern methods of rehabilitation, older people. Results: After skeletal maturity, curves less than 30°do not progress, however most curves greater than 50°continue to progress with approximate change of 1°per year. Bracing is one of the most popular options of scoliosis treatment. Braces usage aims to slow the progression of the curve. However, complications resulting from the physical changes caused by the compression of the body and/or psychological effects due to the disturbance of the appearance while wearing the brace may occure. The Lehnert-Schroth three-plane corrective breath method principles are: a proper breathing technique where the ribs are used as levers and the breath is directed to the unstretched parts of lungs allowing correction of the curvature of the spine, and secondly activation of non-working muscles on the side of the concave curvature. Nevertheless, surgical procedure is advised for curves greater than 45° in immature patients and greater than 50° in mature patients. Conclusions: Scoliosis, defined as spinal and torso deformity in three planes. 80% of all cases of this postural defect are juvenile idiopathic scoliosis (AIS). However, degenerative scoliosis developed during the patient’s life due to the degeneration of the discs of the spine is frequent in people over the age of 65. It often limits daily functioning and can cause severe pain that requires medical intervention. It has been proven that properly selected systematic rehabilitation may lead to significant improvement in the spinal alignment. Nevertheless, in severe cases surgical treatment may be necessary

Sexuality in men with urinary incontinence - summary of current knowledge

Background: The problem of urinary incontinence is facing an increasing population of people. The problem of incontinence is troublesome for both women and men. Incontinence decreases the quality of sexual life. Men struggling with incontinence often have problems with erection and ejaculation. Materials and methods: Analysis of articles in the EBSCO and Google Scholar database using keywords: sexuality, incontinence, men, Results: Urinary incontinence affects both women and men. There are no specific criteria with which this ailment can be diagnosed. Therefore it is impossible to determine how frequent urinary incontinence actually is. It is estimated that it can affect 4-8% of the population around the World. The problem becomes more and more severe, as the number of affected patients grows each year. The urinary incontinence among men leads to sexual dysfunction, which causes various issues in private, professional and social life of such patients. Sexual dysfunction in male patients can lead to lower quality of life, what has a negative influence on their closest family and friends. Urinary incontinence in male patients can be treated pharmacologically or surgically. Only in case the non-invasive treatment fails, more radical methods are perused. Conclusions: Urinary incontinence more often affects women than men. It is a very embarrassing ailment, nevertheless patients under a proper treatment regain not only psychological but also sexual satisfaction. Urinary incontinence should not be a taboo topic, also among men patients. More research is needed to improve treatment program and support of such patients

Atherosclerosis as a problem in postmenopausal women

Introduction: Atherosclerosis is defined as a disease in which plaque, consisting of fat, cholesterol and other substances found in blood, builds up in arteries. This leads to stiffness and narrowing of the blood vessels resulting in limiting the flow of the blood rich in oxygen to tissues. The negative effect of atherosclerosis among women can be opposed by the female hormones. The aim of the article is to review clinical approach to atherosclerosis in post-menopausal women. Material and methods: Articles in the Google Scholar, Pub Med database have been analysed using keywords: atherosclerosis, plaque, cardiovascular diseases, menopause, postmenopausal women, female hormones, estrogens, older people. Results: Atherosclerosis process in the arterial walls is based on accumulation of lipids accompanied by inflammatory factors. One of the most important risk factors of this disease are quantitative and qualitative changes of the plasma lipoprotein, especially increasement of LDL cholesterol after menopause, which can be evaluated during lab tests. The diagnosis of atherosclerosis and its progress can be performed by using different methods, including physical examination and medical imaging. Development of atherosclerosis leads to peripheral artery disease connected with cardiovascular diseases, such as stroke or heart attack, which be life-threatening and should be immediately treated. Conclusions: This risk of the negative effects of atherosclerosis can be decreased by both lifestyle change and pharmacological treatment. The usage of estrogen-based hormone replacement therapy combined with statins in postmenopausal women presents benefits by the decreasement of LDL cholesterol and the increasement of HDL cholesterol and reduction of calcification of coronary vessels, which reduces the risk of cardiovascular diseases. However, the time of the start of hormone replacement therapy is crucial – performed too late can result in additional development of atherosclerotic plaque and increasement of the inflammatory processes in the arteries with advanced atherosclerotic changes

APPLICATION OF PYLON RADON DAUGHTER STANDARD FOR CALIBRATION OF RADIOMETERS

Abstract. Radiometers for measurements of radon daughter potential energy used in the surveillance of the work environment need a systematic calibration. This paper presents how a commercially available device produced by the Pylon Company can be applied. This device allows to produce, simply and directly, standard sources of radon daughters, corresponding with the energy, geometry and properties of radiation originated from an air sample. The calibration yielded the results that proved to be in agreement with those obtained previously by means of radon chamber