Behavioural studies on the ethanol leaf extract of Grewia carpinifolia in Wistar rats

Background: Grewia carpinifolia is a plant commonly used in the tropics to manage various central nervous system (CNS) disorders. However, despite its widespread use no scientific work has been reported to validate these claims.Objectives: To evaluate the activity of G. carpinifolia as it affects behaviour using animal model.Methods: Twenty five adult Wistar rats were randomly divided into five groups (A-E). Group A served as control (given only distilled water), Groups B,C, D and E were administered with single oral dose of ethanol extract of G. carpinifolia leaf at 100, 200, 400 and 800 mg/kg body weight respectively for twenty eight days consecutively. Subsequently, open field test, negative geotaxis and hanging wire test were performed. Body and brain weights were measured and histological examination of the brain was also performed.Results: At the tested doses, the extract significantly increased the time spent on the hanging wire and decreased locomotor activity at 800 mg/kg. No significant difference was observed in body and brain weights of extract treated groups when compared with the control. No visible histological lesion was also observed.Conclusion: The plant extract may improve muscular strength at tested doses and possess CNS depressant activity at 800 mg/kg.Keywords: Grewia carpinifolia, negative geotaxis test, locomotor activity, Wistar rat

Cancer genetics in oncology practice

Cancer is a genetic disease caused by the progressive accumulation of mutations in critical genes that control cell growth and differentiation. Completion of the Human Genome Project promises to revolutionize the practice of Medicine, especially Oncology care. The tremendous gains in the knowledge of the structure and function of human genes will surely impact the diagnosis, prognosis and treatment of cancer. Moreover, it will lead to more effective cancer control through the use of genetics to quantify individual cancer risks. This article reviews the current status of genetic testing and counseling for cancer risk assessment and will suggest a framework for integrating such counseling into oncology practic

Gender disparities in the socio-economic burden of HIV/AIDS among patients receiving care in an HIV clinic in Lagos, Nigeria

Background: In sub-Saharan Africa, women are bearing a heavier burden than men in terms of rate of infection and socio-economic impact of HIV/AIDS. This study was aimed at assessing gender disparities in the socio-economic burden of HIV/AIDS. Methods: This descriptive cross-sectional study was conducted among 422 HIV-positive adult patients attending an HIV clinic in Lagos, Nigeria, selected by multi-stage sampling and interviewed using a pretested, semi-structured questionnaire. Bivariate analysis was used to assess how the socioeconomic constructs differed by gender. Results: This study revealed that females suffered more of the socio-economic consequences of having HIV/AIDS than males; cruelty and isolation were significantly higher among the females (p<0.0001), more females (50.0%) were discriminated against at the workplace compared to males (32.1%) (p=0.005), physical abuse (p=0.002) and extortion (p=0.029) were experienced by more of the females than the males. Also, the cost of care outside of antiretroviral therapy was significantly higher among the females (p= 0.002). Conclusion: Quantifying the social and economic disparities between HIV-infected men and women has shown that the burden is by far higher among women than men. Focused interventions are therefore needed to control the spread of the disease and improve the quality of life of HIV-infected women. Keywords: HIV/AIDS; gender disparities; women; Lagos; Nigeria

Heuristic Evaluation of an Institutional E-learning System: A Nigerian Case.

Many African academic institutions have adopted the use of elearning systems, since they enable students to learn at their own pace, time, and without restriction to the classroom. However, evidence of usability evaluation of e-learning systems in Africa is mostly lacking in the literature. This paper reports the experimental heuristic evaluation of the e-learning system of a Nigerian University. The objective is to demonstrate the application of expertbased usability evaluation techniques such as Heuristic evaluation for assessing the attributes of existing e-learning systems. The study revealed that while the e-learning system has strong credentials in terms of support for Web 2.0 activities, good learning content and boasts of useful e-learning features, improvements are necessary in other areas such as interactive learning, assessment and feedback, and quality of learning content. The study adds to the body of extant knowledge in the area of usability evaluation of e-learning systems in African institution

Morphometrics of foramen magnum in African four-toed hedgehog (Atelerix albiventris)

The purpose of this study was to examine the morphometry of the foramen magnum of African four-toed hedgehog (Atelerix albiventris) in Maiduguri. Fourteen hedgehog skulls (7 male and 7 female each) were used for this study. The overall mean value of foramen magnum height and width were 0.51 ± 0.05 cm and 0.64 ± 0.04 cm while occipital condylar and interparacondylar widths were 1.00 ± 0.12 cm and 1.62 ± 0.07 cm, respectively. There was no significant difference between the two sexes. The foramen magnum index was 83.4 ± 5.51 cm in males and was significantly higher than 76.3 ± 6.37 cm observed in females. The presences of dorsal notches (occipital dysplasia) were observed, that were of three distinct types. It is envisaged, that the study will provide a valuable database on the anatomy of foramen magnum of hedgehogs in Nigeria for morphological, neurological, zooarchaeological, and comparative anatomical studies

Probiotics in the Management of Diseases: A Review

In recent years, there has been an increase in the application of probiotics for the treatment of some diseases and to alleviate the symptoms of many others. Diseases and ailments such as diarrhea, pouchitis, cancer, ulcerative colitis, irritable bowel disease, and a host of others have experienced an increase in the use of certain probiotics bacteria to combat them. The complete mechanisms of action of probiotics in disease management and enhancement of the health of the host remain largely unknown, but the major activity thus appear to be via modulation of immune responses (immunomodulations) and colonization competitive shielding off of pathogens. This paper is set to review some of the various ailments for which probiotics have been used. With an upsurge in the use of probiotics, also comes an increase in skeptism on the safety of their use for medical purpose, the safety concerns that may obstruct effective usage and thus judicious application of probiotics in disease management warrants further investigations