Emergence, Function and Realization

“Realization” and “emergence” are two concepts that are sometimes used to describe same or similar phenomena in philosophy of mind and the special sciences, where such phenomena involve the synchronic dependence of some higher-level states of affairs on the lower-level ones. According to a popular line of thought, higher-level properties that are invoked in the special sciences are realized by, and/or emergent from, lower-level, broadly physical, properties. So, these two concepts are taken to refer to relations between properties from different levels where the lower-level ones somehow “bring about” the higher-level ones. However, for those who specialise in inter-level relations, there are important differences between these two concepts – especially if emergence is understood as strong emergence. The purpose of this chapter is to highlight these differences

Pharmacogenomics in children: advantages and challenges of next generation sequencing applications

Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found why the application of pharmacogenetics is less than initially anticipated, which include the contradictory results obtained for certain variants and the lack of guidelines for clinical implementation. However, more reproducible results are being generated, and efforts have been made to establish working groups focussing on evidence-based clinical guidelines. For another pharmacogenetic hurdle, the speed by which a pharmacogenetic profile for a certain drug can be obtained in an individual patient, there has been a revolution in molecular genetics through the introduction of next generation sequencing (NGS), making it possible to sequence a large number of genes up to the complete genome in a single reaction. Besides the enthusiasm due to the tremendous increase of our sequencing capacities, several considerations need to be made regarding quality and interpretation of the sequence data as well as ethical aspects of this technology. This paper will focus on the different NGS applications that may be useful for pharmacogenomics in children and the challenges that they bring on

DRMs, Innovation and Creation

DRMs are intellectual property institutions. They transpose the empirical principle of copyright, which implicitly recognizes that specific ownership rules should be attached to non scientific creation, into the digital era. The legal protection of DRMs, a private means of enforcing content excludability, participates in the "privatization" of copyright protection. This, in turn, means that a proprietary software — governed by intellectual property rights, reinforced by public law — becomes the key to the vertical relations shaped by exclusive copyright. DRMs consequently represent a major stake in the competition to capture network effects in the content distribution vertical chaincopyright; distribution; DRMs; network effects

A new type of photoionized code required for the new era of X-ray spectroscopy

With the advent of the present and future spatial X-ray missions, it becomes crucial to model correctly the line spectrum of X-ray emitting media. We have built a photoionization code, Titan, solving the transfer of a thousand lines and of the continuum with the "Accelerated Lambda Iteration" method, which is most reliable for line transfer. In all other photoionization codes the line intensities are computed with the so-called "escape probability formalism", used in its simplest approximation. In a previous paper (Dumont et al. 2003), it was shown that this approximation leads to errors which can exceed one order of magnitude in the case a Thomson thickness of the order of unity. We show here that it also happens in the case of a Thomson thickness of 0.001 to 0.1. The errors on the line fluxes and line ratios are of the order of 30% for a column density of 10^{20} cm^{-2}, and a factor five for a column density of 10^{23} cm^{-2}, in conditions appropriate for Seyfert 2 and for the Warm Absorber of Seyfert 1.Comment: 11 pages, 7 figures. accepted by A&

The ABCC6 transporter : what lessons can be learnt from other ATP-binding cassette transporters?

ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a large variety of substrates. Divided in seven families, they represent 48 transporter proteins, several of which have been associated with human disease. Among the latter is ABCC6, a unidirectional exporter protein primarily expressed in liver and kidney. ABCC6 deficiency has been shown to cause the ectopic mineralization disorder pseudoxanthoma elasticum (PXE), characterized by calcification and fragmentation of elastic fibers, resulting in oculocutaneous and cardiovascular symptoms. Unique in the group of connective tissue disorders, the pathophysiological relation between the ABCC6 transporter and ectopic mineralization in PXE remains enigmatic, not in the least because of lack of knowledge on the substrate(s) of ABCC6 and its unusual expression pattern. Because many features, including structure and transport mechanism, are shared by many ABC transporters, it is worthwhile to evaluate if and to what extent the knowledge on the physiology and pathophysiology of these other transporters may provide useful clues toward understanding the (patho)physiological role of ABCC6 and how its deficiency may be dealt with

Laser Doppler Velocimetry for Joint Measurements of Acoustic and Mean Flow Velocities : LMS-based Algorithm and CRB Calculation

This paper presents a least mean square (LMS) algorithm for the joint estimation of acoustic and mean flow velocities from laser doppler velocimetry (LDV) measurements. The usual algorithms used for measuring with LDV purely acoustic velocity or mean flow velocity may not be used when the acoustic field is disturbed by a mean flow component. The LMS-based algorithm allows accurate estimations of both acoustic and mean flow velocities. The Cram\'er-Rao bound (CRB) of the associated problem is determined. The variance of the estimators of both acoustic and mean flow velocities is also given. Simulation results of this algorithm are compared with the CRB and the comparison leads to validate this estimator

Absolute frequency measurements for hyperfine structure determination of the R(26) 62-0 transition at 501.7 nm in molecular iodine

The absolute frequencies of the hyperfine components of the R(26) 62-0 transition in molecular iodine at 501.7 nm are measured for the first time with an optical clockwork based on a femtosecond laser frequency comb generator. The set-up is composed of an Ar+ laser locked to a hyperfine component of the R(26) 62-0 transition detected in a continuously pumped low-pressure cell (0.33 Pa). The detected resonances show a linewidth of 45 kHz (half-width at half-maximum). The uncertainty of the frequency measurement is estimated to be 250 Hz

A Kolmogorov-Smirnov type test for shortfall dominance against parametric alternatives

This paper proposes a Kolmogorov-type test for the shortfall order (also known in the literature as the right-spread or excess-wealth order) against parametric alternatives. In the case of the null hypothesis corresponding to the Negative Exponential distribution, this provides a test for the new better than used in expectation (NBUE) property. Such a test is particularly useful in reliability applications as well as duration and income distribution analysis. The theoretical properties of the testing procedure are established. Simulation studies reveal that the test proposed in this paper performs well, even with moderate sample sizes. Applications to real data, namely chief executive officer (CEO) compensation data and flight delay data, illustrate the empirical relevance of the techniques described in this paper.Right-spread order; Excess-wealth order; New better than used in expectation; Bootstrap; Reliability; CEO compensation; Flight delay