Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study

Introduction: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods: A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results: A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4 % and 85 % respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on Staphylococcus aureus, Streptococcus species, Enterococcus faecalis, Kingella kingae, Neisseria gonorrhoeae, and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1 h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies. Conclusion: The study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting

Convection mantellique, topographie et géoïde sur Mars et Vénus

NANTES-BU Sciences (441092104) / SudocSudocFranceF

SI-Hex: a new catalogue of instrumental seismicity for metropolitan France

Abstract. – The aim of the SI-Hex project (acronym for « Sismicité Instrumentale de l’Hexagone ») is to provide a cata-logue of seismicity for metropolitan France and the French marine economic zone for the period 1962-2009 by taking into account the contributions of the various seismological networks and observatories from France and its neighbouring coun-tries. The project has been launched jointly by the Bureau Central Sismologique Français (CNRS-University/BCSF) and the Laboratoire de Détection et de Géophysique (CEA-DAM/LDG). One of the main motivations of the project is to pro-vide the end user with the best possible information on location and magnitude of each earthquake. So far, due to the vari-ous procedures in use in the observatories, the different locations and magnitudes of earthquakes located in the SI-Hex zone were presenting large discrepancies. In the 2014 version of the catalogue, 1D localizations of hypocentres performed with a unique computational scheme and covering the whole 1962-2009 period constitute the backbone of the catalogue (SI-Hex solutions). When available, they are replaced by more precise localizations made at LDG or, for recent times, by the regional observatories within: 1) the French Alps, 2) the southernmost Alps and the Mediterranean domain including Corsica, 3) the Pyrenees, and 4) the Armorican massif. Moment magnitudes Mw are systematically reported in the SI-Hex catalogue. They are computed from coda-wave analysis of the LDG records for most Mw>3.4 events, and are converte

Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study

Introduction: the BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs).Methods: a study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel.Results: a total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4% and 85% respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on Staphylococcus aureus, Streptococcus species, Enterococcus faecalis, Kingella kingae, Neisseria gonorrhoeae, and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies.Conclusion: the study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting.</p