Collaborative Teaching and Learning: A Model for Building Capacity and Partnerships to Address NTDs

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-05-06T13:25:49Z No. of bitstreams: 1 Wilson Mary Elizabeth Collaborative teaching....pdf: 431785 bytes, checksum: b48099b637f1357115235beafce0ceab (MD5)Made available in DSpace on 2014-05-06T13:25:49Z (GMT). No. of bitstreams: 1 Wilson Mary Elizabeth Collaborative teaching....pdf: 431785 bytes, checksum: b48099b637f1357115235beafce0ceab (MD5) Previous issue date: 2011Department of Global Health and Population. Harvard School of Public Health. Boston, Massachusetts, USAYale School of Public Health Epidemiology of Microbial Disease Division. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Faculdade de Medicina da Bahia. Federal University of Bahia. Salvador, BA, Brasi

Biological activities and chemical constituents of Araucaria angustifolia: An effort to recover a species threatened by extinction

Background: Araucaria angustifolia (Bert.) O. Kuntze (A. brasiliensis), known as Paraná pine, is the sole native gymnosperm of the Atlantic forest in Brazil and has great economic, cultural and social importance. Its seed, known as pinhão, has been consumed since prehistoric times. Besides the nutritional aspects, different parts of A. angustifolia are also used in the Brazilian folk medicine for the treatment of rheumatism, respiratory infections, fatigue, anemia, among other disorders. Timber exploration has dramatically reduced the species population, and currently, A. angustifolia is classified as vulnerable regarding the risk of extinction. Scope and Approach: This review presents the most recently uncovered details about the chemical composition of the various parts of the plant. Emphasis is given to the main isolated and identified compounds or fractions and their corresponding bioactivities. Key Findings and Conclusions:.Apart from the nutritional properties of the pinhão, particularly as a starch source, this review reveals that a number of biological activities have been found in different parts of A. angustifolia (leaves, bark and pinhão coat), such as protection against DNA UV-induced damage, antioxidant, antiinflammatory, antiviral and digestive enzyme inhibiting activities. Further investigations should include parts of A. angustifolia that are currently discarded, such as the bark, bracts and the pinhão coat, with potential for use in pharmaceutical and cosmetic industries. Studies on A. angustifolia must combine two important elements: the need for preservation of a typical ecosystem and the implementation of the A. angustifolia forests as a true economic alternative for local residents.The authors thank the Fundação Araucária for funding this study. R.F. Oliveira, R.C.G. Correa, L. Bertonha and V.G. Correa thank Coordenação de Aperfeiçoamento do Pessoal do Ensino Superior (CAPES) for the financial support provided for their post-graduate studies in Universidade Estadual de Maringá. R.M. Peralta and A. Bracht are research grant recipients of Conselho Nacional de Desenvolvimento Científico e Tecnologia (CNPq)

Avaliação de cultivares de milho no município de Paragominas - Pará.

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Metabolic disruption of gold nanospheres, nanostars and nanorods in human metastatic prostate cancer cells

Nanomaterials offer a broad spectrum of applications in biomedicine. The shapes of gold nanoparticles could modulate tumor cell behavior. Spherical (AuNPsp), stars (AuNPst) and rods (AuNPr) shapes of polyethylene glycol coated-gold nanoparticles (AuNPs-PEG) were synthesized. Metabolic activity, cellular proliferation, and reactive oxygen species (ROS) were measured and the impact of AuNPs-PEG in metabolic enzymes function was evaluated by RT-qPCR in PC3, DU145, and LNCaP prostate cancer cells. All AuNPs were internalized, and the different morphologies of AuNPs showed to be an essential modulator of metabolic activity. For PC3 and DU145, the metabolic activity of AuNPs was found to rank in the following order from lowest to highest: AuNPsp-PEG, AuNPst-PEG, and AuNPr-PEG. Regarding LNCaP cells, the AuNPst-PEG were less toxic, followed by AuNPsp-PEG and AuNPr-PEG, but it seems not to be dose-dependent. The proliferation was lower in AuNPr-PEG in PC3 and DU145 cells but was stimulated around 10% in most conditions (0.001–0.1 mM) in LNCaP cells (not statistically significant). For 1 mM, LNCaP cells showed a significant decrease in proliferation only for AuNPr-PEG. The outcomes of the current study demonstrated that different AuNPs conformations influence cell behavior, and the correct size and shape must be chosen considering its final application in the field of nanomedicine.The author is grateful for the financial support of Foundation for Science and Technology (FCT) through project reference—2022.09032.PTDC and also to FCT through COMPETE to the project NORTE-01-0145-FEDER-024325.info:eu-repo/semantics/publishedVersio

Recomendações de inseticidas para utilização no programa de manejo de pragas da soja - safra 1981/82 - nos Estados do Paraná, São Paulo e Mato Grosso do Sul.

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