Um estudo dos doentes do Centro Hospitalar Universitário Cova da Beira

A Hipertensão Arterial é, hodiernamente, uma das principais doenças crónicas da população e representa uma prevalência em Portugal de 42,2% segundo o estudo PHYSA. (1,2) Grande parte destes doentes são orientados em Medicina Geral e Familiar. No entanto, os casos mais complexos e refratários ao tratamento são encaminhados para a consulta hospitalar. Com controlo adequado da pressão arterial, apenas uma pequena percentagem dos pacientes hipertensos desenvolvem episódios de crise hipertensiva, ocorrendo mais, este evento adverso, nos indivíduos de raça negra, idosos e naqueles pouco aderentes ao tratamento com anti-hipertensores. (3) Emergência hipertensiva é definida como Hipertensão Arterial grau 3, ou seja, pressão arterial sistólica superior a 180 mmHg e/ou pressão arterial diastólica superior a 110 mmHg associada a lesão de órgão-alvo. (4) Ainda assim é frequente no Serviço de Urgência a ocorrência de emergências hipertensivas, que necessitam de atenção imediata, de modo a diminuir os valores de pressão arterial, normalmente com terapêutica intravenosa. (4) Com este estudo pretende-se caracterizar os doentes com emergência hipertensiva do Centro Hospitalar Universitário Cova da Beira, avaliar se é dado o correto encaminhamento para consulta especializada e, por outro lado, quais eram previamente acompanhados na consulta hospitalar.Arterial Hypertension is, nowadays, one of the main chronic diseases in population and represents a prevalence in Portugal of 42%, according to the PHYSA study. (1,2) Most of these patients are followed by general practice and family medicine. However, the most complex cases and refractory to treatment are sent to specialized hospital appointments. With the suitable control of blood pressure values, only a small percentage of hypertensive patients will develop episodes of hypertensive crisis, which occur more frequently in black individuals, elderly and those who do not fulfill the therapy with anti-hypertensives. (3) Hypertension emergencies is defined as severe hypertension (grade 3), that is, systolic blood pressure above 180 mmH and/or diastolic blood pressure above 110 mmHg, associated with acute hypertension-mediated organ damage.(4) Nevertheless, in the Emergency Room, it is common the occurrence of hypertensive emergencies, requiring immediate attention to lower blood pressure, usually with intravenous therapy.(4) With this study, it is intended to provide a detailed characterization of the patients with hypertensive emergencies in Centro Hospitalar Universitário Cova da Beira in order to assess whether it is given the correct forwarding to a specialized hospital consultation and, on the other hand, who were already appointed in hospital consultation

Partial correctness and continuous integration in computer supported education

In this paper we support the idea that students and teachers will benefit from a computer-based system that assesses programming exercises and provide immediate and detailed feedback: students would be able to evolve in the right direction and teachers would follow and assess more fairly their students. This assessment should outperform the typical right/wrong evaluation returned by existing tools, allowing for a flexible partial evaluation. Moreover, we adopt a concept from Agile Development, the Continuous Integration (CI), to improve students’ effectiveness. The applicability of CI reflects a better monitoring by the teams and their individual members, also providing the ability to improve the speed of the development. Besides the description of the capabilities that we require from an Automatic Grading System (AGS), we discuss iQuimera, an improved AGS that we are working on, that implements our teaching/learning principles.Fundação para a Ciência e a Tecnologia (FCT

Eletroterapia IVL no tratamento de Covid-19 e sequelas no sistema nervoso central / IVL electrotherapy in the treatment of Covid-19 and central nervous system sequelae

Pacientes internados por causa da Covid-19 foram tratados com eletroterapia e obtiveram bons resultados em relação à recuperação. Dois hospitais do Brasil utilizaram as correntes elétricas para recuperar pacientes que ficaram muitos dias etubados na UTI. O aparelho emissor de terapia infravermelho longo ativa trilhões de células por minuto, eliminando ácido lático e toxinas, promovendo a melhora da circulação de oxigênio e aumento do sistema imunológico por oxigenação celular. 

Seleção assistida por marcadores de linha mantenedora dentro de uma população de cebola tropical

The traditional onion (Allium cepa) hybrid production requires the development of maintainer and male sterile lines and also a pollinator line with good specific combination ability. We report the identification of maintainer and male-sterile onion lines within the Brazilian 'Baia Periforme' derived population, 'Alfa São Francisco', associating random field pairing of male-fertile plants with selected male-sterile plants and PCR-based marker system monitoring S, T and N-cytoplasms. Male-sterile plants produced flowers with light green anthers which were easily detected in the field. A frequency of 2.0% of male-sterile plants was estimated in the 'Alfa São Francisco' sampled population. Male-sterile plants produced the 5'cob-marker 180-bp and the orfA501-marker 473-bp fragments, suggesting the T-cytoplasm type, while the maintainer line produced only the 5'cob-marker 180-bp. These identified lines will be important to develop tropical onion hybrids well-adapted to Brazilian low latitudes and to future comparative studies with other onion cytoplasmic genic male sterility systems.A produção tradicional de híbrido de cebola (Allium cepa) requer o desenvolvimento de linhas mantenedoras e linhas macho estéreis, bem como uma linha polinizadora de boa capacidade específica de combinação. Reporta-se a identificação de linhas de cebola mantenedora e macho-estéreis numa população 'Alfa São Francisco' derivada da brasileira 'Baia Periforme', associando pareamento ao acaso no campo de plantas férteis com plantas macho-estéreis e sistema de PCR para monitoramento dos citoplasmas S, T e N. Plantas macho-estéreis produziram flores com anteras verde-claras, que foram facilmente identificadas no campo. A freqüência de 2,0% de plantas macho-estéreis foi estimada dentro de uma amostra da população 'Alfa São Francisco'. Plantas macho-estéreis produziram o marcador 5´cob de 180-pb e o marcador orfA501 de 473-pb, sugerindo que o citoplasma é do tipo T, enquanto a linha mantenedora da macho-esterilidade produziu apenas o marcador 5'cob de 180-pb. Essas linhas identificadas serão importantes para o desenvolvimento de híbridos de cebola tropical, bem adaptados às áreas de baixa latitude do Brasil e para estudos comparativos no futuro com outros sistemas da macho-esterilidade citoplasmática gênica de cebola

The Biorefinery of the Marine Microalga Crypthecodinium cohnii as a Strategy to Valorize Microalgal Oil Fractions

ABSTRACT: Chrypthecodinium cohnii lipids have been almost exclusively used as a source of Docosahexaenoic acid (DHA). Such an approach wastes the remaining microalgal lipid fraction. The present work presents a novel process to produce C. cohnii biomass, using low-cost industrial by-products (raw glycerol and corn steep liquor), in a 7L-bioreactor, under fed-batch regime. At the end of the fermentation, the biomass concentration reached 9.2 g/L and the lipid content and lipid average productivity attained 28.0% (w/w dry cell weight) and 13.6 mg/L h, respectively. Afterwards the microalgal biomass underwent a saponification reaction to produce fatty acid (FA) soaps, which were further converted into FA ethyl ester (FA EE). C. cohnii FA EE mixture was then fractionated, using the urea complexation method at different temperatures, in order to obtain a polyunsaturated fatty acid ethyl ester (PUFA EE) rich fraction, that could be used for food/pharmaceutical/cosmetic purposes, and a saturated fatty acid ethyl ester (SAT EE) rich fraction, which could be used as biodiesel. The temperature that promoted the best separation between PUFA and SAT EE, was -18 degrees C, resulting in a liquid fraction with 91.6% (w/w) DHA, and a solid phase with 88.2% of SAT and monounsaturated fatty acid ethyl ester (MONOUNSAT), which could be used for biodiesel purposes after a hydrogenation step.info:eu-repo/semantics/publishedVersio

Small mammals and microhabitat selection in forest fragments in the transition zone between Atlantic Forest and Pampa biome

Natural resources are depleted in fragmented landscapes that have their vegetation also altered. As a result, the microhabitat diversity and the composition and distribution of local species are affected. In this study, we evaluated the small mammals' community diversity, composition and microhabitat selection in two Atlantic Forest fragments, in an ecotone area with the Pampa biome, southern Brazil. We recorded five rodents (Akodon montensis, Oligoryzomys nigripes, Sooretamys angouya, Juliomys pictipes and the exotic Rattus rattus) and one marsupial (Didelphis albiventris). Both fragments were dominated by the generalist rodent A. montensis. Akodon montensis and O. nigripes showed similar habitat preferences: ground covered by rocks and higher values of vegetation obstruction. Sooretamys angouya preferred places with higher abundance of trees. Fruit availability was important for A. montensis and D. albiventris, highlighting the importance of this food resource for local wildlife, and the potential role of these species as seed predators and dispersers. Small species richness, the presence of an exotic species and high dominance level suggest that the study area is highly degraded

Association of organic peeling with sangria for rejuvenation

O presente estudo versa sobre o uso do peeling orgânico intercalado com mescla de sangria para rejuvenescimento, a fim de que se consiga uma eficácia no tratamento de rejuvenescimento em região diversificada.The present study deals with the use of organic peeling interspersed with a blend of bleed for rejuvenation, in order to achieve an efficacy in the treatment of rejuvenation in a diversified region

Associação de peeling polihidroxiácidos com técnicas de sangria e intradermoterapia para rejuvenescimento do tecido por retração

The present study deals with the use of organic peeling interspersed with a blend of bleed for rejuvenation, in order to achieve an efficacy in the treatment of rejuvenation in a diversified region.O presente estudo versa sobre o uso do peeling orgânico intercalado com mescla de intradérmicos x técnicas de sangria para rejuvenescimento, a fim de que se consiga uma eficácia no tratamento de rejuvenescimento em região diversificada por retração tecidual

Retraction by bleed therapy for tissue flaccidity and growth factors

Retração por terapia de sangria para flacidez tecidual e fatores de crescimentoBleeding therapy retraction for tissue flaccidity and growth factor

Intracellular link between botulinum toxin and covid-19

A Organização Mundial da Saúde (OMS) declarou em 2019 uma pandemia causada pelo novo coronavírus, chamado de Sars-Cov-2. Estudos demonstram que poderá estar relacionado ao coronavírus de morcegos e pangolins e teria saltado para a espécie humana durante o último trimestre de 2019. A toxina botulínica conhecida popularmente como Botox®, é uma proteína produzida pela bactéria Clostridium botulinum capaz de bloquear os sinais de impulso específicos para tal área levando assim ao relaxamento local, atuando na paralisação da musculatura subjacente das linhas indesejadas. O objetivo do presente estudo foi identificar se a vacina Coronavac é capaz de alterar a ação da toxina botulínica. Sendo assim foram analisados 61 indivíduos. Concluindo que o grupo que recebeu a vacina demonstrou alteração na eficácia da toxina.The World Health Organization (WHO) declared in 2019 a pandemic caused by the new coronavirus, called Sars-Cov-2. Studies show that it is closely related to bat and pangolin coronaviruses and would have jumped into the human species during the last quarter of 2019. Botulinum toxin popularly known as Botox®, is a protein produced by the bacterium Clostridium botulinum is able to block the signs of specific impulses for such an area thus leading to local relaxation, acting in the paralysis of the underlying musculature of the unwanted lines. The aim of the present study was to identify whether the Coronavac vaccine is capable of altering the action of botulinum toxin. Thus, 61 individuals were analyzed. Concluding that the group that received the vaccine demonstrated alteration in the effectiveness of the toxin