Recurrent idiopathic parotitis in childhood

Introduction: Recurrent idiopathic parotitis (RIP) is a frequent etiology of repeated inflammatory episodes of the parotid gland, in childhood. Objectives: To review current literature on the etiology, clinical presentation, diagnosis and treatment of RIP. Development: RIP is characterized by repeated episodes of swelling and pain in the parotid gland, usually accompanied by fever and malaise. Aetiology is multifactorial and, to date, unclear. Diagnosis is essentially clinical. Despite its benign character, recurrent parotitis can be a signal of other diseases, particularly in case of delayed onset of symptoms (from six-year-old) and bilateral involvement. The use of complementary tests should be individualized. Ultrasound is the diagnostic tool of choice and shows non-obstructive dilatation of glandular ducts (sialectasis). Treatment is mainly symptomatic. Prognosis is good with tendency to remission at puberty. Conclusions: RIP is a benign and self-limited condition. However, recurrent parotitis episodes should prompt investigation for underlying diseases, particularly in cases of late onset of symptoms (after age six years) and bilateral involvement.Introdução: Na infância, a parotidite recorrente idiopática (PRI) é uma causa frequente de inflamação recorrente e autolimitada da glândula parótida. Objetivo: O presente trabalho tem como objetivo fazer uma revisão bibliográfica atual sobre a etiologia, apresentação clínica, diagnóstico e tratamento da PRI. Desenvolvimento: A PRI caracteriza-se por episódios repetidos de tumefação e dor parotídea habitualmente acompanhados de febre e mal-estar. A sua etiologia é multifatorial e, até hoje, pouco esclarecida. O diagnóstico é essencialmente clínico. Apesar do caráter benigno e autolimitado, a parotidite recorrente poderá ser uma manifestação de doenças subjacentes, em especial quando os episódios se iniciam a partir dos seis anos de idade e o atingimento é bilateral. O recurso a exames complementares deve ser ponderado caso a caso. A ecografia é o exame de eleição e evidencia dilatações não obstrutivas dos canais glandulares. O tratamento é sobretudo sintomático. O prognóstico é favorável com tendência para a remissão a partir da puberdade. Conclusão: A PRI é uma entidade benigna e autolimitada. Contudo, face a episódios frequentes, deve ser pesquisada doença subjacente, especialmente quando o início dos episódios é posterior aos seis anos e o atingimento bilateral

"Aproximaciones teóricas desde la situación universitaria para establecer el deber ser"

La necesidad de dirigir la formación de profesionales universitarios y de egresados de los diferentes niveles de educación, en general, constituye un problema que se plantea la Universidad en distintas partes del mundo, independientemente de las condiciones económicas, políticas e ideológicas de determinado país. Sabemos que la sociedad invierte importantes recursos en la formación de profesionales a los cuales exige la idoneidad necesaria para responder a los retos propios del campo en el cual se desempeñan. Puesto que actualmente en el mundo el conocimiento es la principal fuerza productiva, ninguna sociedad puede eximirse de la formación de una masa crítica de intelectuales en los distintos campos.. No se trata sólo de responder a los retos específicos planteados en las distintas áreas de formación profesional; también se requiere un intenso trabajo cultural para promover el análisis informado y crítico de los problemas por parte de la población. El futuro de la sociedad depende de manera sustancial del conocimiento y la responsabilidad de los egresados de la educación superior."Llegado a este punto, conviene reafirmar que la posibilidad de producir cambios en las instituciones universitarias requiere detenerse en la práctica política y en la práctica administrativa. Recuperar la relación entre la política universitaria y cambio deseado, es imprescindible para que la transformación sea el resultado del ethos común de la comunidad universitaria y de la sociedad y no el mero resultado de la tecnoburocracia reformista que la sujeta a un estricto sistema de regulación con respecto al mercado y a esquemas autoritarios de imposición desde el Estado." La cuestión más importante de la Universidad actual es su adaptación a los cambios que la sociedad le exige, tanto en relación a las enseñanzas que imparte como a la investigación que realiza y las acciones de extensión y/o servicios. Una adaptación de este tipo no ha sido nunca fácil para la Universidad y, casi siempre, los cambios en ella se han producido tras un periodo de crisis más o menos profunda de nuestra institución

Cocinando letras: estrategias de inclusión social desde la estética relacional

El taller "Cocinando letras" dentro del proyecto "Sin perfil". El libro como experiencia diversa realizado con la Fundación San Martín de Porres, recoge la experiencia artística de una propuesta inclusiva entre el alumnado de la Facultad de Bellas Artes de la Universidad Complutense de Madrid y un grupo de personas sin hogar en riesgo de exclusión social. La propuesta, inscrita en el proyecto Aprendizaje-Servicio UCM, contempla un programa de actividades basado en la realización de tipos móviles y en la composición tipográfica posterior; punto de partida para el análisis de la estética relacional surgida en torno a la ‘mesa’ como marco referencial en el que poder debatir las barreras sociales que giran alrededor del acto alimenticio. Fruto de esta experiencia artística es el libro arte textil, "Sin perfil", y la performance "Sopa de letras" realizada durante el Banquete final del evento.; The workshop "Cooking letters" within the project "No profile". The book as a diverse experience, carried out with the San Martín de Porres Foundation, collects the artistic experience of an inclusive proposal between the students of the Faculty of Fine Arts of the Complutense University of Madrid, and a group of homeless people at risk of social exclusion. The proposal, part of the UCM Service-Learning project, includes a program of activities based on the creation of movable type and the subsequent typographic composition, as a starting point for the analysis of the relational aesthetics arising around the ‘table’; a referential framework in which to discuss the social barriers that revolve around the act of eating. The result of this artistic experience is the textile art book, "No profile", and the performance "Alphabet soup", carriedout during the final banquet of the event

Binding free energy calculations to rationalize the interactions of huprines with acetylcholinesterase

In the present study, the binding free energy of a family of huprines with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation method, based on hybrid quantum mechanics and molecular mechanics potentials. Binding free energy calculations and the analysis of the geometrical parameters highlight the importance of the stereochemistry of huprines in AChE inhibition. Binding isotope effects are calculated to unravel the interactions between ligands and the gorge of AChE. New chemical insights are provided to explain and rationalize the experimental results. A good correlation with the experimental data is found for a family of inhibitors with moderate differences in the enzyme affinity. The analysis of the geometrical parameters and interaction energy per residue reveals that Asp72, Glu199, and His440 contribute significantly to the network of interactions between active site residues, which stabilize the inhibitors in the gorge. It seems that a cooperative effect of the residues of the gorge determines the affinity of the enzyme for these inhibitors, where Asp72, Glu199, and His440 make a prominent contribution

Layered double hydroxides-indomethacin nanohybrids: intercalation, pH influence, stability and release properties

In this work, three pH values (8, 9 and 10) were studied for the insertion of Indomethacin (Indo) molecules into Layered Double Hydroxides (LDHs). The obtained results showed that the LDH materials have been a good storage for the drug. LDHs provide thermal stability with an increase in the thermal decomposition of the drug around 100°C more. Indo into LDHs exhibited higher photostability to UV light irradiation. In vitro drug release experiments in a phosphate buffer solution (pH = 7.4) have been carried out. The loading amount of intercalated Indo was increased to 66 % at pH 8, and showed a profile of sustained release of 97 % in 8h. The release profiles were fitted by mathematical models, which describe various kinetic models that served to investigate the drug release mechanism, being the Bhaskar kinetics model the most appropriate. The results showed that the nanohybrids can be used as an effective drug delivery system.Fil: Mendieta, Silvia Nazaret. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; ArgentinaFil: Oliva, Marcos Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Perez, Celso Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; ArgentinaFil: Reyes Nuñez, Patricio. Universidad de Concepción; ChileFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Crivello, Mónica Elsie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentin

Las ocupaciones tardías de Pampa y Norpatagonia. Tratamiento de evidencias pre y post-contacto. Algunas reflexiones.

Fil: Berón, Mónica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Oliva, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Berón, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Museo etnográfico; Argentina.Fil: Oliva, Fernando. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina11 ref

Estrategias adaptativas en la región pampeana: continuidad y cambios

Fil: Oliva, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oliva, Fernando. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Berón, Mónica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Berón, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Museo etnográfico; ArgentinaSíntesis de ponencias presentadas en la Mesa 1 del III Encuentros de Arqueología realizado en la Facultad de Filososía y Letras de la Universidad de Buenos Aires, los días 3 y 4 de diciembre de 19925 ref

Temperature dependence of dynamic, tunnelling and kinetic isotope effects in formate dehydrogenase

The origin of the catalytic power of enzymes has been a question of debate for a long time. In this regard, the possible contribution of protein dynamics in enzymatic catalysis has become one of the most controversial topics. In the present work, the hydride transfer step in the formate dehydrogenase (FDH EC 1.2.1.2) enzyme is studied by means of molecular dynamic (MD) simulations with quantum mechanics/molecular mechanics (QM/MM) potentials in order to explore any correlation between dynamics, tunnelling effects and the rate constant. The temperature dependence of the kinetic isotope effects (KIEs), which is one of the few tests that can be studied by experiments and simulations to shed light on this debate, has been computed and the results have been compared with previous experimental data. The classical mechanical free energy barrier and the number of recrossing trajectories seem to be temperature-independent while the quantum vibrational corrections and the tunnelling effects are slightly temperature-dependent over the interval of 5–45 °C. The computed primary KIEs are in very good agreement with previous experimental data, being almost temperature-independent within the standard deviations. The modest dependence on the temperature is due to just the quantum vibrational correction contribution. These results, together with the analysis of the evolution of the collective variables such as the electrostatic potential or the electric field created by the protein on the key atoms involved in the reaction, confirm that while the protein is well preorganised, some changes take place along the reaction that favour the hydride transfer and the product release. Coordinates defining these movements are, in fact, part of the real reaction coordinate

A bonding evolution theory study of the reaction between methylidyne radical, CH(X2Π), and cyclopentadiene, C5H6

In the present work, bonding evolution theory (BET) is applied to gain insight about the complex reaction between methylidyne radical, CH (X2 Π) and cyclopentadiene, C5H6. The novelty of this work is that all reaction pathways take place in the doublet electronic state and an unpaired electron is always present. Therefore, taking the aforementioned reaction as explicative example, we have shown how to apply the BET tool to these kinds of open-shell systems, by splitting the wavefunctions into the corresponding alpha and beta parts. As an added value, we have included a point-by-point description of the algorithm we use to make it available for the readers. Hence, a complete analysis of bond breaking/forming and charge redistribution along the multi-channels connecting reactants to products via the transition states and intermediates is presented. We show how the BET brings about the representation of the electronic flow in complex molecular rearrangements like the one herein studied, yielding a transparent rationalization based on the electron density redistribution. The present study allows us to conclude that along the different processes giving rise to the benzene product, the breaking of a C C sigma bond initiates the electronic rearrangement in two cases, but not in the third one. The last step in these processes can be described as an initial weakening of the C H bond with a quasi-hydride formation and a final retro-transfer of electrons from the quasi-hydride to the C H bond. On the other hand, in the way to the fulvene product, the breaking of the C C sigma bond takes place after previous electronic redistribution. Neither the last step of the fulvene formation process nor the interesting H transfer described in the second one, can be explaiFunding for open access charge: CRUE-Universitat Jaume