Counterstreaming strahls and heat flux dropouts as possible signatures of local particle acceleration in the solar wind

Suprathermal electrons with energies of ~70 eV and above are observed at 1 au as dispersionless halo electrons and magnetic field-aligned beams of strahls. For a long time, it has been thought that both populations originate only from the solar corona, and that the only active process impacting their properties in the solar wind is scattering. This view has consequently impacted the interpretation of typical patterns of pitch-angle distributions (PADs) of suprathermal electrons. Meanwhile, recent observational studies supported by numerical simulations have shown that there is an unaccounted population of electrons accelerated to suprathermal energies at reconnecting current sheets (RCSs) and 3D dynamical plasmoids (or 2D magnetic islands (MIs)) directly in the heliosphere. We present multispacecraft observations of counterstreaming strahls and heat flux dropouts in PADs within a region filled with plasmoids and RCSs unaffected by interplanetary shocks, comparing observed PAD features with those predicted by particle-in-cell simulations. We show typical PAD patterns determined by local acceleration of thermal-core electrons up to hundreds of electron volts. Resulting PAD views depend on properties and topology of particular RCSs, MIs, and plasma/magnetic field parameters. Our study suggests that solar wind-borne suprathermal electrons coexist with those of solar origin. Therefore, some of heat flux dropout and bidirectional strahl events can be explained by local dynamical processes involving magnetic reconnection. Possible implications of the results for the interpretation of the actively debated decrease in the strahl/halo relative density with heliocentric distance and puzzling features of suprathermal electrons observed at crossings of the heliospheric current sheet and cometary comas are also discussed

Students’ Competence Assessment Methods

The problem of establishing methods and technologies for the assessment of students’ competence is still relevant. Introduction of competence-based approach at Russian universities (in the framework of the existing State Educational Standards) did not solve the problem. The development of efficient methods and measuring procedures of competence assessment is possible only on the basis of mathematical modeling and system analysis

Arquetipos en la estructura del metaconcepto

The history of studying the cognitive structure of our consciousness and its minimal mental unit dates back to the beginning of the 20th century and is associated with the name of the Russian scientist S.А. Askoldov, the scientific legacy of whom was not actually forgotten during the Soviet period. Appealing to the methods of representation of knowledge about the world has aroused the interest in the concept category. The basics which reflect primary human values are metaconcept. The present paper proves that the basis of the structure of the meta concept is an archetype.La historia del estudio de la estructura cognitiva de nuestra conciencia y su unidad mental mínima se remonta a principios del siglo XX y está asociada con el nombre del científico ruso S.А. Askoldov, cuyo legado científico no fue olvidado en realidad durante el período soviético. Apelar a los métodos de representación del conocimiento sobre el mundo ha despertado el interés en la categoría de concepto. Los conceptos básicos que reflejan los valores humanos primarios son el metaconcepto. El presente trabajo demuestra que la base de la estructura del metaconcepto es un arquetipo

Students’ Competence Assessment Methods

The problem of establishing methods and technologies for the assessment of students’ competence is still relevant. Introduction of competence-based approach at Russian universities (in the framework of the existing State Educational Standards) did not solve the problem. The development of efficient methods and measuring procedures of competence assessment is possible only on the basis of mathematical modeling and system analysis

Frequency of EGFR mutations in non-small cell lung cancer patients: screening data from West Siberia

BACKGROUN

Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics—A Novel Way to Combat Antibiotic Resistance?

Rapidly growing resistance of pathogenic bacteria to conventional antibiotics leads to inefficiency of traditional approaches of countering infections and determines the urgent need for a search of fundamentally new anti-infective drugs. Antimicrobial peptides (AMPs) of the innate immune system are promising candidates for a role of such novel antibiotics. However, some cytotoxicity of AMPs toward host cells limits their active implementation in medicine and forces attempts to design numerous structural analogs of the peptides with optimized properties. An alternative route for the successful AMPs introduction may be their usage in combination with conventional antibiotics. Synergistic antibacterial effects have been reported for a number of such combinations, however, the molecular mechanisms of the synergy remain poorly understood and little is known whether AMPs cytotoxicy for the host cells increases upon their application with antibiotics. Our study is directed to examination of a combined action of natural AMPs with different structure and mode of action (porcine protegrin 1, caprine bactenecin ChBac3.4, human alpha- and beta-defensins (HNP-1, HNP-4, hBD-2, hBD-3), human cathelicidin LL-37), and egg white lysozyme with varied antibiotic agents (gentamicin, ofloxacin, oxacillin, rifampicin, polymyxin B, silver nanoparticles) toward selected bacteria, including drug-sensitive and drug-resistant strains, as well as toward some mammalian cells (human erythrocytes, PBMC, neutrophils, murine peritoneal macrophages and Ehrlich ascites carcinoma cells). Using “checkerboard titrations” for fractional inhibitory concentration indexes evaluation, it was found that synergy in antibacterial action mainly occurs between highly membrane-active AMPs (e.g., protegrin 1, hBD-3) and antibiotics with intracellular targets (e.g., gentamicin, rifampcin), suggesting bioavailability increase as the main model of such interaction. In some combinations modulation of dynamics of AMP-bacterial membrane interaction in presence of the antibiotic was also shown. Cytotoxic effects of the same combinations toward normal eukaryotic cells were rarely synergistic. The obtained data approve that combined application of antimicrobial peptides with antibiotics or other antimicrobials is a promising strategy for further development of new approach for combating antibiotic-resistant bacteria by usage of AMP-based therapeutics. Revealing the conventional antibiotics that increase the activity of human endogenous AMPs against particular pathogens is also important for cure strategies elaboration

Annexins in Influenza Virus Replication and Pathogenesis

Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome. Treatment of IAV infections is complicated because the virus can evade host immunity through antigenic drifts and antigenic shifts, to establish infections making new treatment options desirable. Annexins (ANXs) are a family of calcium and phospholipid binding proteins with immunomodulatory roles in viral infections, lung injury, and inflammation. A current understanding of the role of ANXs in modulating IAV infection and host responses will enable the future development of more effective antiviral therapies. This review presents a comprehensive understanding of the advances made in the field of ANXs, in particular, ANXA1 and IAV research and highlights the importance of ANXs as a suitable target for IAV therapy

Deletion of annexin A1 in mice upregulates the expression of its receptor, Fpr2/3, and reactivity to the AnxA1 mimetic peptide in platelets

Annexin A1 (ANXA1) is an endogenous protein, which plays a central function in the modulation of inflammation. While the functions of ANXA1 and its exogenous peptidomimetics, N-Acetyl 2-26 (ANXA1Ac2-26) in the modulation of immunological responses of neutrophils and monocytes have been investigated in detail, their effects on the modulation of platelet reactivity, haemostasis, thrombosis, and platelet-mediated inflammation remain largely unknown. Here, we demonstrate that the deletion of Anxa1 in mice upregulates the expression of its receptor formyl peptide recep-tor 2/3 (Fpr2/3, orthologue of human FPR2/ALX). As a result, the addition of ANXA1Ac2-26 to platelets exerts an activatory role in platelets as characterised by its ability to increase the levels of fibrinogen binding, and exposure of P-selectin on the surface. Moreover, ANXA1Ac2-26 increased the development of platelet-leukocyte aggregates in whole blood. The experiments carried out us-ing a pharmacological inhibitor (WRW4) for FPR2/ALX, and platelets isolated from Fpr2/3 -deficient mice ascertained that the actions of ANXA1Ac2-26 are largely mediated through Fpr2/3 in platelets. Together, this study demonstrates that in addition to its ability to modulate inflamma-tory responses via leukocytes, ANXA1 modulates platelet function which may influence throm-bosis, haemostasis, and platelet-mediated inflammation under various pathophysiological settings

Additional acceleration of solar-wind particles in current sheets of the heliosphere

Particles of fast solar wind in the vicinity of the heliospheric current sheet (HCS) or in a front of interplanetary coronal mass ejections (ICMEs) often reveal very peculiar energy or velocity profiles, density distributions with double or triple peaks, and well-defined streams of electrons occurring around or far away from these events. In order to interpret the parameters of energetic particles (both ions and electrons) measured by the WIND spacecraft during the HCS crossings, a comparison of the data was carried out with 3-D particle-in-cell (PIC) simulations for the relevant magnetic topology (Zharkova and Khabarova, 2012). The simulations showed that all the observed particle-energy distributions, densities, ion peak velocities, electron pitch angles and directivities can be fitted with the same model if the heliospheric current sheet is in a status of continuous magnetic reconnection. In this paper we present further observations of the solar-wind particles being accelerated to rather higher energies while passing through the HCS and the evidence that this acceleration happens well before the appearance of the corotating interacting region (CIR), which passes through the spacecraft position hours later. We show that the measured particle characteristics (ion velocity, electron pitch angles and the distance at which electrons are turned from the HCS) are in agreement with the simulations of additional particle acceleration in a reconnecting HCS with a strong guiding field as measured by WIND. A few examples are also presented showing additional acceleration of solar-wind particles during their passage through current sheets formed in a front of ICMEs. This additional acceleration at the ICME current sheets can explain the anticorrelation of ion and electron fluxes frequently observed around the ICME's leading front. Furthermore, it may provide a plausible explanation of the appearance of bidirectional "strahls" (field-aligned most energetic suprathermal electrons) at the leading edge of ICMEs as energetic electrons generated during a magnetic reconnection at the ICME-front current sheet

Dynamical small-scale magnetic islands as a source of local acceleration of particles in the solar wind

We present observations of energetic particle flux increases up to 1 MeV at 1 AU, which cannot be associated with ordinary mechanisms of particle acceleration, such as acceleration at shocks or at the Sun. Such unusual energetic particle events very likely have a local origin. Multi-spacecraft observations show that numerous cases of energetic particle flux enhancements and spikes correspond to passages of spacecraft through areas filled with magnetic islands with a typical width similar to 0.01-0.001AU that experience dynamical merging or/and contraction. The presence of magnetic islands inside magnetically confined cavities in the solar wind may lead to local particle energization, especially in the case when the particles have already been pre-accelerated to keV energies, for example, at shocks or due to magnetic reconnection at the heliospheric current sheet. We consider different magnetic configurations that provide favourable conditions for both the appearance of small-scale magnetic islands and their confinement