The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

Metabolic pathways enriched with genes differentially expressed in ISIAH and WAG renal medulla. (XLS 41 kb

A role for Phospholipase D in Drosophila embryonic cellularization

BACKGROUND: Cellularization of the Drosophila embryo is an unusually synchronous form of cytokinesis in which polarized membrane extension proceeds in part through incorporation of new membrane via fusion of apically-translocated Golgi-derived vesicles. RESULTS: We describe here involvement of the signaling enzyme Phospholipase D (Pld) in regulation of this developmental step. Functional analysis using gene targeting revealed that cellularization is hindered by the loss of Pld, resulting frequently in early embryonic developmental arrest. Mechanistically, chronic Pld deficiency causes abnormal Golgi structure and secretory vesicle trafficking. CONCLUSION: Our results suggest that Pld functions to promote trafficking of Golgi-derived fusion-competent vesicles during cellularization

Tillgänglighet i kulturmärkta hus

Arbetet undersöker de synskadades och blindas uppfattningar om den offentliga miljön, samt belyser förutsättningar och konkreta utformningar som möjliggör de synskadades vistelse i offentligheten.    Arbetet behandlar två olika intressen som står mot varandra; bevarandevärdet och de funktionshindrades möjligheter.   Jag undersökte hur synskadade och blinda orienterar sig i offentliga miljöer och på vilket sätt jag kunde applicera deras kunskap i ett trapphus på Birger Jarlsgatan 20 i centrala Stockholm som är blåmärkt.   Genom teorier, intervjuer, observationer och självrapporter kunde jag bilda en uppfattning om hur personer orienterar sig i offentlighet. Jag kunde lokalisera farliga platser i den aktuella lokalen samt fick uppfattning om hur det är att inte kunna ta del av den visuella världen.  This work investigates the visually impaired and blind perceptions of the public environment, and highlights opportunities and practical designs that enable the visually impaired being in public.   The work deals with two different opposing interests: the conservation value and the disabled peoples capability in public space.   I examined how the visually impaired and blind people orient themselves in public places and how I could apply their knowledge in a stairwell at Birger Jarlsgatan 20 in central Stockholm, which is landmark, specifically “blåmärkt”.   Through theory, interviews, observations and self-reports, I could form an idea of how people orient themselves in the public space. I could locate dangerous places in the relevant room and got ideas about how it is to not to take advantage of the visual world

THE ANALYSIS OF GENE FUSED (Fu) APPEARANCE OF THE CHIMERA MICE

The opbject of investigation: the house mouse (Mus musculus). It has been shown, that the gene-supressor does not insert the influence on the penetrance and expressiveness of the mutation Fu of the chimera mice. For the first time it has been shown, that the introduction of the gonadotropic hormones in the she-mice changes the frequency of the Fu mutation appearance. The new data about the interaction of genes on the intercellular level and about the influence of the gonadotropic hormones on the early development of mouse embryo with the hormones introduction in the different stages of the females estrous cycle have been obtainedAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Advances of Brain Transcriptomics

Advancements in RNA sequencing technology in past decade have underlined its power for elucidating the brain gene networks responsible for various stressful factors, as well as the pathologies associated with both genetically determined neurodegenerative diseases and those acquired during the lifespan [...

Recent Advances in C₅ and C₆ Sugar Alcohol Synthesis by Hydrogenation of Monosaccharides and Cellulose Hydrolytic Hydrogenation over Non-Noble Metal Catalysts

A new reality of the 21st century is the transition to a new type of economy and energy concepts characterized by the replacement of existing petrochemical routes to a bio-based circular economy. The needs for new strategies in obtaining basic products from bio-based resources with minimum CO2 traces has become mandatory. In this review, recent trends in the conversion of biomass-derived molecules, such as simple monomeric sugars and cellulose, to industrially important C5 and C6 sugar alcohols on heterogeneous catalysts based on non-noble metals are discussed focusing on the influence of catalyst structures and reaction conditions used on the substrate conversion and product selectivity. The challenges and prominent ideas are suggested for the further development of catalytic hydrogenation of naturally abundant carbohydrates to value-added chemicals on non-noble metal catalysts