Специфика индивидуально-авторского стиля создания цветовой сенсорной образности в поэтическом тексте: лингвокультурологический анализ

Sensory perception of the world is the ontological basis of human existence that helps an individual to be oriented in the world. It also helps one to find the path in the most difficult circumstances of social communication. This makes it relevant to pay attention to sensory mechanisms and their functions in various fields of knowledge, from psychology to linguacultural studies. In modern linguistics, the category of sensory imagery is one of the complex phenomena, based on the author’s individual sociocultural experience. This experience is especially vividly realized in a poetic text, which is the highest form of sensory expression. In a poetic text, one can single out an independent block of color information, deliberately embedded in the content by its creators as an additional visual means. At the same time, this functionality of color is determined primarily by the peculiarities of individual author’s style in the creation of sensory visual color imagery.Sensory perception of the world is the ontological basis of human existence that helps an individual to be oriented in the world. It also helps one to find the path in the most difficult circumstances of social communication. This makes it relevant to pay attention to sensory mechanisms and their functions in various fields of knowledge, from psychology to linguacultural studies. In modern linguistics, the category of sensory imagery is one of the complex phenomena, based on the author’s individual sociocultural experience. This experience is especially vividly realized in a poetic text, which is the highest form of sensory expression. In a poetic text, one can single out an independent block of color information, deliberately embedded in the content by its creators as an additional visual means. At the same time, this functionality of color is determined primarily by the peculiarities of individual author’s style in the creation of sensory visual color imagery.Чувственное мировосприятие есть онтологическая основа существования человека, помогающая ему ориентироваться в природном мире. Она же помогает ему ориентироваться и в более сложных обстоятельствах социальной коммуникации. Все это делает актуальным внимание к сенсорным механизмам и их функционированию в самых разных областях знания, от психологии до лингвокультурологии. В современной лингвистике категория сенсорной образности выступает одним из сложных феноменов, в основе своей опирающийся на индивидуальный социокультурный опыт автора. Особенно ярко данный опыт реализуется в поэтическом тексте, представляющим собой наивысшую форму чувственной экспрессии. В таком тексте можно выделить самостоятельный блок информации, передающейся с помощью цвета, сознательно вложенный в содержание его создателями в качестве дополнительного изобразительного средства. При этом подобное функционирование цвета определяется, в первую очередь индивидуально-авторскими особенностями в создании сенсорной зрительно-цветовой образности

Особенности современной семьи: модель взаимоотношений в России и мире

Modern society is currently undergoing the stage of transition. Such a change has an impact on all social institutions, including the family and family-marital relations. People are becoming increasingly liberated and independent. This affects marital relations, which are currently being built according to new paradigms associated with greater responsibility for oneself and less for the partner. All these are new phenomena of our social reality, requiring a new understanding and development of new social practice. To validly disclose the features of the modern model of family relations, we will build our considerations in line with evolutionary, functional, empirical and interactionist approaches, based on the assertion that the family is, first of all, a small social group, where each partner has their own, often opposing, interests, and which at the same time acts as an integral social system.Современное общество в настоящее время переживает переходный этап. Такое изменение оказывает влияние на все социальные институты, включая семью и семейно-брачные отношения. Люди становятся все более раскрепощенными и независимыми. Это сказывается на супружеских отношениях, которые в настоящее время строятся в соответствии с новыми парадигмами, связанными с большей ответственностью за себя и меньшей степени за партнера. Все это - новые явления нашей социальной реальности, требующие нового понимания и развития новой социальной практики. Чтобы достоверно раскрыть особенности современной модели семейных отношений, мы строим наши рассуждения в русле эволюционного, функционального, эмпирического и интеракционистского подходов, основанных на утверждении, что семья — это прежде всего небольшая социальная группа, где каждый партнер имеет свои, часто противоположные, интересы и которая в то же время выступает как целостная социальная система

Histone H3 Acetylation is Asymmetrically Induced Upon Learning in Identified Neurons of the Food Aversion Network in the Mollusk Helix Lucorum

Regulation of gene expression is an essential step during long-term memory formation. Recently, the involvement of DNA-binding transcription factors and chromatin remodeling in synaptic plasticity have been intensively studied. The process of learning was shown to be associated with chromatin remodeling through histone modifications such as acetylation and phosphorylation. We have previously shown that the MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase) regulatory cascade plays a key role in the food aversion conditioning in the mollusk Helix. Specifically, command neurons of withdrawal behavior exhibit a learning-dependent asymmetry (left–right) in MAPK/ERK activation. Here, we expanded our molecular studies by focusing on a potential MAPK/ERK target – histone H3. We studied whether there is a learning-induced MAPK/ERK-dependent acetylation of histone H3 in command neurons RPa(2/3) and LPa(2/3) of the right and left parietal ganglia and whether it is asymmetrical. We found a significant learning-dependent increase in histone H3 acetylation in RPa(2/3) neurons but not in LPa(2/3) neurons. Such an increase in right command neurons depended on MAPK/ERK activation and correlated with a lateralized avoidance movement to the right visible 48 h after training. The molecular changes found in a selective set of neurons could thus represent a lateralized memory process, which may lead to consistent turning in one direction when avoiding a food that has been paired with an aversive stimulus

Development of the Republic of Sakha (Yakutia)'s Shadow Economy Assessment Methodology

The purpose of the article is to study the shadow economy assessment methodology. This article presents a comprehensive study of the parameters of a shadow economy, considers its essence, and defines its terminology. This study outlines the historical approach to the development of the shadow economy, both in Russia and worldwide, and gives a brief analysis of the economy of the Republic of Sakha. The authors examined the specifics of the statistical methods applied in assessing various structural elements of a shadow economy and measured and assessed the shadow economy in this region. The research conducted enabled the authors to formulate the main measures required to reduce the shadow economy. The scientific novelty is justified by the research results, which included studying and summarizing a wide range of published and unpublished materials, the examination of the initial and transitional periods of the shadow economy development in Yakutia. The article reveals the main causes and conditions that lead to the formation of the shadow economy in various sectors of the Yakutia economy. The solutions and suggestions proposed in the article are aimed at reducing the shadow economy parameters. The scientific research results are of theoretical and applied importance for public administration and authorities to improve the effectiveness of the fight against the shadow economy manifestations

Isolation, characterization, and metal response of novel, acid-tolerant Penicillium spp. from extremely metal-rich waters at a mining site in Transbaikal (Siberia, Russia)

The role of fungi in metal cycling in acidic environments has been little explored to date. In this study, two acid-tolerant and metal-resistant Penicillium isolates, strains ShG4B and ShG4C, were isolated from a mine site in the Transbaikal area of Siberia (Russia). Waters at the mine site were characterized by extremely high metal concentrations: up to 18 g l−1 Fe and >2 g l−1 each of Cu, Zn, Al, and As. Both isolates were identified as Penicillium spp. by phylogenetic analyses and they grew well in Czapek medium acidified to pH 2.5. Resistance to Cu, Cd, Ni, Co, and arsenate was in the range of 1–10 g l−1. Further experiments with Penicillium strain ShG4C demonstrated that growth in Cu-containing media was accompanied by the precipitation of Cu-oxalate (moolooite) and the formation of extracellular vesicles enriched in Cu on the mycelia. Vesicles were greatly reduced in size in Cd-containing media and were not formed in the presence of Ni or Co. Cd-oxalate was detected as a crystalline solid phase in Cd-exposed mycelia. Hydrated Nisulfate (retgersite) and Co-sulfate (bieberite) were detected in mycelia grown in the presence of Ni and Co, respectively. The results demonstrated that acid-tolerant and metal-resistant Penicillium constitute a component in extremophilic microbiomes, contributing to organic matter breakdown and formation of secondary solid phases at pH ranges found in acid rock drainage

Genome sequence of the copper resistant and acid-tolerant Desulfosporosinus sp. BG isolated from the tailings of a molybdenum-tungsten mine in the Transbaikal area

Here, we report on the draft genome of a copper-resistant and acidophilic Desulfosporosinus sp. BG, isolated from the tailings of a molybdenum-tungsten mine in Transbaikal area. The draft genome has a size of 4.52 Mb and encodes transporters of heavy metals. The phylogenetic analysis based on concatenated ribosomal proteins revealed that strain BG clusters together with the other acidophilic copper-resistant strains Desulfosporosinus sp. OT and Desulfosporosinus sp. I2. The K+-ATPase, Na+/H+ antiporter and amino acid decarboxylases may participate in enabling growth at low pH. The draft genome sequence and annotation have been deposited at GenBank under the accession number NZ_MASS00000000

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Although small molecule inhibitors of B-cell receptor-associated kinases have revolutionized therapy in chronic lymphocytic leukemia (CLL), responses are incomplete. Pro-survival signaling emanating from the microenvironment may foster therapeutic resistance of the malignant B cells resident in the protective lymphoid niches. B-cell activating factor (BAFF) is critical to the survival of both healthy and neoplastic B cells. However, the pro-survival pathways triggered by BAFF have not been fully characterized. Here we show that BAFF elicited resistance to spontaneous and drug-induced apoptosis in stromal co-cultures, induced activation of both canonical and non-canonical NFκB signaling pathways, and triggered B-cell receptor signaling in CLL cells, independently of IGHV mutational status. SYK, a proximal kinase in the B-cell receptor signaling cascade, acted via STAT3 to bolster transcription of the anti-apoptotic protein Mcl-1, thereby contributing to apoptosis resistance in BAFF-stimulated cells. SYK inhibitor entospletinib downregulated Mcl-1, abrogating BAFF-mediated cell survival. BAFF-B-cell receptor crosstalk in neoplastic B cells was mediated by SYK interaction with TRAF2/TRAF3 complex. Thus, SYK inhibition is a promising therapeutic strategy uniquely poised to antagonize crosstalk between BAFF and B-cell receptor, thereby disrupting the pro-survival microenvironment signaling in chronic lymphocytic leukemia

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin