14 research outputs found
Opportunism as a Factor in the Branding of Rural Areas
The article analyzes the socio-economic problems and prospects of development of rural areas of Ukraine. The potential and possibilities of implementation of territorial branding models of such development are substantiated. The key role of the factor of opportunism of the economic agents of the domestic rural territories as restriction of development is defined. The model of typical conflict at implementing a universal project of territorial branding in accordance with the concept of public interest in the interpretation of the Pareto Effect is presented. The contents of brand management is substantiated with use of the istrumentarium of contract theory. The contents of a typical contract agreement at implementing the projects of branding of rural areas is developed. The peculiarity of the above mentioned is the achievement of managerial balance between the functions of planning and organization, motivation, control and sanctions, including self-improvement of contractual relations, as well as formalization of the above specified in terms of the corresponding settlement
ЕЛЕКТРОЛІТНО-ПЛАЗМОВЕ ПОЛІРУВАННЯ МІДІ
Сучасні промислові технологічні процеси вимагають спеціальної підготовки металевих поверхонь. В даний час існують різні методи обробки поверхні металу. Серед них можна виділити метод електролітно-плазмового полірування (PEP – plasma electrolytic polishing), як інноваційний, завдяки своїм екологічним властивостям, низьким енергозатратами на одиницю оброблюваної поверхні, високою швидкістю модифікації та можливість обробки деталей складної геометричної форми. Основною перевагою даного методу модифікації поверхні є його екологічна чистота, що дозволяє застосовувати дану технологію для харчової та фармацевтичної промисловості. Незважаючи на велику кількість публікацій у журналах, електролітно-плазмове полірування залишається інноваційним методом модифікації поверхні, яку необхідно ретельно вивчати, щоб поліпшити розуміння фізичних процесів та оптимізувати процес модифікації поверхні. У даній статті розглянуто процес електролітно-плазмового полірування мідних виробів у розчині сульфату амонію з додаванням сірчаної кислоти. Експеримент був розділений на два етапи. Спочатку зразки оброблялися протягом 600 секунд кожен для зняття температурних характеристик, при цьому спостерігалася сильна кореляція між струмом навантаження і температурою електроліту. Залежність струму від температури електроліту показала чотири різні режими обробки. Один з режимів показав найкращі результати. Під час другого етапу експерименту проводилася послідовна обробка об'єктів від 30 до 600 секунд. У результаті проведених досліджень були отримані оптимальні режими полірування мідних об'єктів
Formation of a Decentralized Model of Financial and Economic Regulation of Environmental Protection and Nature Management Activity: The Focus on European Experience
It is found that in the context of martial law and deepening decentralization of power and local government reform, there is a need to form a decentralized model of financial and economic regulation of environmental management, which will allow more efficient accumulation of natural resource and environmental payments and ensure their targeted use in terms of expanded reproduction of natural resource potential and environmental protection. It is substantiated that a distinctive feature of the interbudgetary distribution of natural resource rent and environmental tax is their excessive centralization, which does not allow forming a sufficient financial base of local self-government for financial and investment support aimed at the reproduction of natural resource potential, development of a network of natural and economic and environmental infrastructure and environmental protection. It is identified that in 1999-2021, the dynamics of the proportion of local budgets in the total revenues of rent and fees for the use of other natural resources and environmental taxes to the Consolidated Budget of Ukraine shows a downward trend, which indicates the existence of gaps between the declared priorities of fiscal deregulation in the system of natural resource management and environmental protection and the actual decentralization of the accumulation of environmental payments in public budgets. It is found that the effectiveness of the decentralized model of financial and economic regulation of environmental management directly depends on the growth of the concentration of eco-resource payments in local budgets, which, in combination with the spatial and territorial communal assets, will allow diversifying the sources and methods of financial and investment support for rationalizing the use of natural raw materials and environmental protection in the adjacent territories. It is substantiated that the basis for building a decentralized model of financial and economic regulation of environmental management should be the Polish experience of organizing financial and investment support for environmental rehabilitation through the formation of a network of environmental protection funds at both the national and regional levels
CdS Nanocrystallines: Synthesis, Structure and Nonlinear Optical Properties
We report the synthesis, structure and nonlinear optical properties of
cadmium sulphide (CdS) nanocrystallines (NCs) synthesized electrochemically
both with and without detergent ATLAS G3300. Relevant structural and
morphological features are explored by X-ray diffraction and scanning electron
microscopy (SEM) techniques. The efficiency of the second harmonic generation
(SHG) appears to be strongly dependent on the energy density of the incident
fundamental laser radiation and NC sizes.Comment: 2020 IEEE 15th International Conference on Advanced Trends in
Radioelectronics, Telecommunications and Computer Engineering (TCSET),
Conference Location: Lviv-Slavske, Ukraine, 25-29 February 2020, 5 pages, 8
figures, 3 table
Wpływ Z56822977 na biosyntezę serotoniny w mózgu szczurów z otyłością wywołaną przez podawanie glutaminianu sodu
Wstęp: Badanie przeprowadzono w celu wyjaśnienia wpływu Z56822977 na biosyntezę serotoniny w mózgu szczurów z otyłością wywołaną podawaniem glutaminianu sodu (monosodium glutamate, MSG).
Materiał i metody: W badaniu wykorzystano 18 samców szczura. Zwierzęta podzielono na trzy grupy: 1 — grupa kontrolna, 2 — grupa MSG, 3 — grupa MSG + Z56822977. Szczurzym oseskom w grupie 2 i 3 podawano podskórnie MSG rozpuszczony w soli fizjologicznej w dawce 4 mg/g masy ciała w objętości 8 μl/g w 2., 4., 6., 8. i 10. dniu życia. Grupie 3 podawano doustnie wodny roztwór Z56822977 w dawce 25 mg/kg w objętości 1 ml/kg. Pierwszą dawkę Z56822977 podawano po ukończeniu 4 tygodni życia, a następnie kontynuowano podawanie badanej substancji cyklicznie wedlug schematu tydzień podawania substancji badanej/3 tygodnie przerwy. Zwierzętom z grupy MSG podawano odpowiednio 1 ml/kg wody doustnie. Przez pierwsze 4 miesiące życia szczury otrzymywały standardową karmę. Zmierzono zawartość serotoniny, tryptofanu i 5-hydroksytryptofanu (5-HTr) oraz aktywność hydroksylazy tryptofanowej (tryptophan hydroxylase, TRH), dekarboksylazy aminokwasów (amino acid decarboxylase, AADC) i monoaminooksydazy (MAO) w tkance mózgowej.
Wyniki: Wykazano, że podawanie Z56822977 ma pozytywny wpływ na główne wskaźniki otyłości, co odzwierciedlają zmiany podstawowych parametrów fizjologicznych i biochemicznych [zmniejszenie masy ciała o 13% vs. MSG (p < 0,05); zmniejszenie wskaźnika masy ciała (body mass index, BMI), wskaźnika Lee oraz masy tkanki tłuszczowej trzewnej odpowiednio o 18%, 7% i 55%, (p < 0,05) w porównaniu z grupą MSG]. Zawartość tryptofanu i serotoniny była istotnie niższa (p < 0,05) u szczurów z otyłością wywołaną przez MSG. W badaniach wykazano, że u otyłych szczurów aktywność MAO zwiększa się o 97% (p < 0,05), a aktywność TRH i AADC odpowiednio o 44% i 53% (p < 0,05). Podawanie Z56822977 powodowało zwiększenie zawartości serotoniny i tryptofanu w mózgach szczurów i przywracało poziom aktywności enzymów (MAO, TRH, AADC) do wartości mierzonych u zwierząt kontrolnych.
Wnioski: Wiadomo, że otyłość wiąże się z zaburzeniem syntezy serotoniny w mózgu szczurów. Jednak podawanie Z56822977 prowadzi do normalizacji stężenia serotoniny i tryptofanu oraz przywrócenia prawidłowej aktywności enzymów uczestniczących w biosyntezie i degradacji serotoniny. Podawanie Z56822977, cząsteczki wpływającej na układ serotoninergiczny, może powodować korzystne efekty w leczeniu otyłości wywołanej przez MSG u szczurów. Można rozważać zastosowanie cząsteczki Z56822977 jako nowego leku stosowanego w otyłości, jednak konieczne są dalsze badania w celu potwierdzenia jej działania
An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries
An
approach to the parallel synthesis of hydantoin libraries by
reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino
esters was developed. To demonstrate utility of the method, a library
of 1158 hydantoins designed according to the lead-likeness criteria
(MW 200–350, cLogP 1–3) was prepared. The success rate
of the method was analyzed as a function of physicochemical parameters
of the products, and it was found that the method can be considered
as a tool for lead-oriented synthesis. A hydantoin-bearing submicromolar
primary hit acting as an Aurora kinase A inhibitor was discovered
with a combination of rational design, parallel synthesis using the
procedures developed, in silico and in vitro screenings
The correction of the metabolic parameters of msg-induced obesity in rats by 2-[4-(benzyloxy) phenoxy] acetic acid
Epidemiological data showed that the number of obese people increases swiftly in all countries. Obesity can evoke metabolic syndrome or second type diabetes (T2D). So, the aim of our study was to investigate the influence of 2-[4-(benzyloxy) phenoxy] acetic acid on metabolic parameters of monosodium glutamate (MSG)-induced obesity in rats. We divided the rats as follows: 1- control group, 2 - MSG-group, 3 - MSG + 2-[4-(benzyloxy) phenoxy] acetic acid group. We investigated anthropometric parameters and blood biochemistry. It was established that MSG induced the development of visceral obesity in rats, in particular, it increased the Lee index, body mass index, deposits of subcutaneous, gonadal and visceral adipose tissue. The administration of 2-[4-(benzyloxy) phenoxy] acetic acid decreased metabolic parameters evoked by MSG. After obesity induction, there was recorded significant growth of cholesterol, triglycerides, and LDL cholesterol blood levels and significant decline in HDL cholesterol blood levels. There was a significant reduction in triglycerides, LDL cholesterol and VLDL, in 2-[4-(benzyloxy) phenoxy] acetic acid - treated group. Our results represent the basis for development of new treatment of obesity and associated conditions
A Close-up Look at the Chemical Space of Commercially Available Building Blocks for Medicinal Chemistry
Improving the Organizational and Economic Support for the Development of Enterprises in the Hospitality Industry in the Use of Information and Communication Technologies
Conceptual foundations of organizational and economic support for the development of enterprises in the hospitality industry have been developed, taking into account the level of use of information and communication technologies. It has been determined that the main results of the influence of information technologies on the hospitality industry are the optimization of business processes, as well as the transformation of the target consumer of hospitality services. The types of information and communication technologies are systematized depending on the direction of the business processes of the cycle of providing hospitality services. It has been substantiated that through the active use of information and communication technologies, hospitality industry enterprises satisfy the needs of customers in full in accordance with modern requirements. The relationship was established between the results of assessing the level of organizational and economic support for the development of information and communication technologies and the strategic choice of enterprises in the hospitality industry. Three types of strategies are identified – information expansion, improvement, retention and further development – depending on the low, medium and high level of development of information and communication technologies, respectively. The directions of increasing the level of development of information and communication technologies of the hospitality industry at different levels are proposed. The developed theoretical and methodological provisions can be useful in the formation of the concept of strategic development of the hospitality industry. The use of the proposed toolkit reflects the results, both quantitatively (increasing demand for hospitality services, improving financial performance, etc.) and in a qualitative form (improving the quality of service, creating a positive image, etc.)
Design of anodes for IT SOFC: Effect of complex oxide promoters and pd on activity and stability in methane steam reforming of Ni/YSZ (ScSZ) cermets
Effect of fluorite-like or perovskite-like complex oxide promoters and Pd on the performance of Ni/8YSZ and Ni/ScSZ anode materials in CH4 steam reforming (SR) or selective oxidation (SO) by O-2 into syngas was studied. The spatial uniformity of dopants distribution in composites was controlled by TEM combined with EDX analysis, while the lattice oxygen mobility and reactivity were estimated by CH4 and H-2 temperature-programmed reduction (TPR). The oxide promoters suppress the coke deposition even at stoichiometric H2O/CH4 ratio, while doping by Pd ensures a good performance at moderate (similar to 550 degrees C) temperatures required for the Intermediate -Temperature Solid Oxide Fuel Cells (IT SOFC) operation.</p