Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia

Objective: The authors systematically reviewed the literature on psychological approaches to treating the neuropsychiatric symptoms of dementia.Method: Reports of studies that examined effects of any therapy derived from a psychological approach that satisfied prespecified criteria were reviewed. Data were extracted, the quality of each study was rated, and an overall rating was given to each study by using the Oxford Centre for Evidence-Based Medicine criteria.Results: A total of 1,632 studies were identified, and 162 satisfied the inclusion criteria for the review. Specific types of psychoeducation for caregivers about managing neuropsychiatric symptoms were effective treatments whose benefits lasted for months, but other caregiver interventions were not. Behavioral management techniques that are centered on individual patients' behavior or on caregiver behavior had similar benefits, as did cognitive stimulation. Music therapy and Snoezelen, and possibly sensory stimulation, were useful during the treatment session but had no longer-term effects; interventions that changed the visual environment looked promising, but more research is needed.Conclusions: Only behavior management therapies, specific types of caregiver and residential care staff education, and possibly cognitive stimulation appear to have lasting effectiveness for the management of dementia-associated neuropsychiatric symptoms. Lack of evidence regarding other therapies is not evidence of lack of efficacy. Conclusions are limited because of the paucity of high-quality research ( only nine level-1 studies were identified). More high-quality investigation is needed

SOME BIOCHEMICAL PROPERTIES OF THYMUS LEUKEMIA ANTIGENS SOLUBILIZED FROM CELL MEMBRANES BY PAPAIN DIGESTION

Thymus leukemia (TL) alloantigenic activity was solubilized by papain proteolytic digestion from intact RADA1 tumor cells. If the cells were labeled with amino acids and fucose, the TL alloantigen could be isolated as a doubly labeled glycoprotein fragment by indirect precipitation from the papain digest. This TL glycoprotein fragment was approximately the same mol wt as the papain-digested H-2.4 alloantigen fragment as judged by chromatography on Sephadex G-150 in sodium dodecyl sulfate. The carbohydrate chain of the TL glycoprotein obtained by exhaustive pronase digestion behaved as a glycopeptide of approximately 4,500 mol wt, as compared with the glycopeptide of the H-2.4 alloantigen that had a mol wt of about 3,500. Thus, the TL alloantigen can be solubilized by papain digestion as a glycoprotein fragment similar in mol wt to the H-2 alloantigen glycoprotein fragment. The carbohydrate chain of the TL glycoprotein is larger than the H-2 carbohydrate chain

Exploring the progenitors of brightest cluster galaxies at z ∼ 2

We present a new method for tracing the evolution of brightest cluster galaxies (BCGs) from z ∼ 2 to z ∼ 0. We conclude on the basis of semi-analytical models that the best method to select BCG progenitors at z ∼ 2 is a hybrid environmental density and stellar mass ranking approach. Ultimately, we are able to retrieve 45 per cent of BCG progenitors. We apply this method on the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey, Ultra Deep Survey data to construct a progenitor sample at high redshift. We furthermore populate the comparisons in local Universe by using Sloan Digital Sky Survey data with statistically likely contamination to ensure a fair comparison between high and low redshifts. Using these samples we demonstrate that the BCG sizes have grown by a factor of ∼3.2 since z ∼ 2, and BCG progenitors are mainly late-type galaxies, exhibiting less concentrated profiles than their early type local counterparts. We find that BCG progenitors have more disturbed morphologies. In contrast, local BCGs have much smoother profiles. Moreover, we find that the stellar masses of BCGs have grown by a factor of ∼2.5 since z ∼ 2, and the star formation rate of BCG progenitors has a median value of 13.5 Mʘ yr‾¹, much higher than their quiescent local descendants. We demonstrate that over z = 1–2 star formation and merging contribute equally to BCG mass growth. However, merging plays a dominant role in BCG assembly at z ≲ 1. We also find that BCG progenitors at high z are not significantly different from other galaxies of similar mass at the same epoch. This suggests that the processes which differentiate BCGs from normal massive elliptical galaxies must occur at z ≲ 2

Littlestock Brook natural flood management pilot: hydrological and water quality monitoring and analysis report

The Littlestock Brook Natural Flood Management (NFM) trial was a pilot project that ran from 2016 to 2022. Key objectives were to reduce flood risk to Milton-under-Wychwood and enhance the river environment. Through partnership working the Environment Agency collaborated with Wild Oxfordshire, the Evenlode Catchment Partnership, Bruern Estate and the local community to deliver NFM measures. UKCEH has undertaken a detailed monitoring campaign to assess the effectiveness of the measures on reducing flood flows and improving water quality. This report describes the monitoring network, observational methods, equipment adopted, the data processing and analysis undertaken

Evaluating land use and management Natural Flood Management potential

Soil use and management as a form of Natural Flood Management (NFM) has potential to increase infiltration and soil water storage above and below ground. As a result, it can slow the flow of water and reduce flooding caused by surface run-off, rivers and groundwater. Here, we report findings from the LANDWISE project, which examined the potential of land use and management in lowland groundwater-fed catchments in the River Thames Basin, England. We focused on five soil classes within two geology types: shallow permeable soils on carbonate geology (Limestone and Chalk) and deep clay soils on mudstone geology; across agricultural land, grassland and woodland. We compared different farming systems, including conventional, innovative and organic agriculture. We gathered empirical evidence of within and between field variation for different soil use and management strategies, through a broad survey of 164 fields and an in-depth survey of 7 sites. We show that both land use and soil type are significant in affecting bulk density. We also show correlation between organic matter and bulk density, which is important for NFM as organic matter content can be controlled by land use and management practices. We adopted a co-production research approach, to deliver usable impacts for farmers who will ultimately deliver NFM through land use change and management. This work will inform policy and design and delivery of agri-environment schemes; such as the soil survey scheme, a key part of the DEFRA soil action plan. It will help co-deliver NFM alongside other ecosystem services

A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi

The process by which bacteria regulate flagellar expression is known as phase variation and in Salmonella enterica this process permits the expression of one of two flagellin genes, fliC or fljB, at any one time. Salmonella Typhi (S. Typhi) is normally not capable of phase variation of flagellar antigen expression as isolates only harbour the fliC gene (H:d) and lacks an equivalent fljB locus. However, some S. Typhi isolates, exclusively from Indonesia, harbour an fljB equivalent encoded on linear plasmid, pBSSB1 that drives the expression of a novel flagellin named H:z66. H:z66+S. Typhi isolates were stimulated to change flagellar phase and genetically analysed for the mechanism of variation. The phase change was demonstrated to be unidirectional, reverting to expression from the resident chromosomal fliC gene. DNA sequencing demonstrated that pBSSB1 linear DNA was still detectable but that these derivatives had undergone deletion and were lacking fljAz66 (encoding a flagellar repressor) and fljBz66. The deletion end-point was found to involve one of the plasmid termini and a palindromic repeat sequence within fljBz66, distinct to that found at the terminus of pBSSB1. These data demonstrate that, like some Streptomyces linear elements, at least one of the terminal inverted repeats of pBSSB1 is non-essential, but that a palindromic repeat sequence may be necessary for replication

Do trees in UK-relevant river catchments influence fluvial flood peaks?: a systematic review

This report describes a systematic review of the evidence in support of the primary question “Do trees in UK-relevant river catchments influence fluvial flood peaks?

Refractive Index of Humid Air in the Infrared: Model Fits

The theory of summation of electromagnetic line transitions is used to tabulate the Taylor expansion of the refractive index of humid air over the basic independent parameters (temperature, pressure, humidity, wavelength) in five separate infrared regions from the H to the Q band at a fixed percentage of Carbon Dioxide. These are least-squares fits to raw, highly resolved spectra for a set of temperatures from 10 to 25 C, a set of pressures from 500 to 1023 hPa, and a set of relative humidities from 5 to 60%. These choices reflect the prospective application to characterize ambient air at mountain altitudes of astronomical telescopes.Comment: Corrected exponents of c0ref, c1ref and c1p in Table

Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry

We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass spectrometry, and bioinformatics. Through this approach, we have acquired a large amount of peptide fragmentation spectra from size-resolved fractions of the proteomes of several breast tumors, tissue peripheral to the tumor, and samples from patients undergoing noncancer surgery. Label-free quantitation was used to generate protein abundance maps for each proteome and perform comparative analyses. The mass spectrometry data revealed distinct qualitative and quantitative patterns distinguishing the tumors from healthy tissue as well as differences between metastatic and non-metastatic human breast cancers including many established and potential novel candidate protein biomarkers. Selected proteins were evaluated by Western blotting using tumors grouped according to histological grade, size, and receptor expression but differing in nodal status. Immunohistochemical analysis of a wide panel of breast tumors was conducted to assess expression in different types of breast cancers and the cellular distribution of the candidate proteins. These experiments provided further insights and an independent validation of the data obtained by mass spectrometry and revealed the potential of this approach for establishing multimodal markers for early metastasis, therapy outcomes, prognosis, and diagnosis in the future. © 2008 American Chemical Society