3 research outputs found
Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort
Background. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed
in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should
be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype.
Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of
previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB.
Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied.
Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT
scans to assess bronchial anatomy and the presence of emphysema (β200 HU). Findings
in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features.
Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT
scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33)
or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Ξ=β17.7%; p=0.001) and inspiratory capacity
(Ξ=β21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Ξ=+6.2% (p=0.021), +0.36%
(p=0.017) and +3.5% (p=0.098), respectively).
Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related
COPD and warrant further study..info:eu-repo/semantics/publishedVersio
Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort
CITATION: Allwood, B. W., et al. 2017. Obstructive pulmonary disease in patients with previous tuberculosis : pathophysiology of a community-based cohort. South African Medical Journal, 107(5):440-445, doi:10.7196/SAMJ.2017.v107i5.12118.The original publication is available at http://www.samj.org.zaBackground. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype.
Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB.
Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (β200 HU). Findings in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features.
Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33) or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Ξ=β17.7%; p=0.001) and inspiratory capacity (Ξ=β21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Ξ=+6.2% (p=0.021), +0.36% (p=0.017) and +3.5% (p=0.098), respectively).
Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related COPD and warrant further study.http://www.samj.org.za/index.php/samj/article/view/11885Publisher's versio
Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort
Background. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype.Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB.Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (<β950 HU), gas trapping (<β860 HU) and fibrosis (>β200 HU). Findings in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features.Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33) or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Ξ=β17.7%; p=0.001) and inspiratory capacity (Ξ=β21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Ξ=+6.2% (p=0.021), +0.36% (p=0.017) and +3.5% (p=0.098), respectively).Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related COPD and warrant further study