Estudio citogenético en luziola peruviana juss. ex j. f. gmel y sus híbridos intergenéricos con arroz (oryza sativa l.)

El correcto comportamiento cromosómico durante la meiosis protege la integridad estructural del genoma y la segregación correcta a las células hijas (Pawlowski, 2010). La fiel transmisión de estas estructuras requiere de una reorganización cromosómica extensa y de la formación de estructuras únicas de la división celular (Franklin y Cande, 1999). El Programa de arroz del CIAT encuentra en la variabilidad genética de las especies de la tribu Oryzeae, un recurso esencial para lograr avances en el desarrollo de variedades élites que respondan a las demandas de la población. Oryza sativa L. presenta flores completas, estambres y pistilo en la misma flor (Sanabria, 2006). La Luziola peruviana presenta flores monoicas con estambres y pistilo en inflorescencias separadas en la misma planta, (Swallen, 1965). En la tribu Oryzeae la presencia de monoecia afirma la propuesta de evolución del dioicismo a partir del hermafroditismo, como resultado del control genético sobre el desarrollo de estructuras reproductivas bisexuales hacia estructuras unisexuales (Guo y Ge, 2005). En este trabajo se evaluó la compatibilidad entre los dos genomas de Oryza sativa L. y Luziola peruviana Juss. ex J. F. Gmel en sus híbridos intergenéricos, al estudiar el comportamiento cromosómico durante la meiosis

Nonparametric modeling of the eight-hour average air pollution due to Carbon Monoxide and Tropospheric Ozone

Resumen Se presenta la modelación del comportamiento típico de la concentración promedio octohoraria del monóxido de carbono (CO) y ozono troposférico (O3) a lo largo de un día, mediante la implementación de un modelo de regresión no paramétrica. Los datos utilizados provienen de las mediciones registradas por el Sistema de Vigilancia de la Calidad del Aire (SVCA) de la ciudad de Santiago de Cali, para los años 2003 y 2006. Los resultados obtenidos muestran que el comportamiento de la contaminación octohoraria por O3 supera el límite máximo permitido de la Norma Colombiana en las estaciones ubicadas en la zona sur de Cali, mientras que la contaminación octohoraria por CO se aproxima al límite máximo permitido en el centro de la ciudad, coincidente con la presencia de fuentes móviles. Las bandas de variabilidad asociadas a la modelación de la contaminación octohoraria del CO, muestran indicios de que existen diferencias del comportamiento de este contaminante por tipo de día y zonas de vigilancia en los años de estudio; mientras que para el O3, el comportamiento difiere por tipo de día y zonas de vigilancia solo en el año 2006. Abstract We model the typical behavior of the eight-hour average concentration of Tropospheric Ozone (O3) and Carbon Monoxide (CO) throughout one day. Modeling is conducted using a nonparametric regression technique. Data come from the Cali’s Air Quality Surveillance System (SVCA), and correspond to the years 2003 and 2006. Results show that in the Cali's South side, the O3 eight hour contamination levels exceed the Colombian standard limit value. Meanwhile, in Cali's downtown the CO eight-hour average contamination levels are very close to the Colombian standard limit. Variability bands associated with the modeling of the typical daily behavior of the eight-hour concentration of CO, show evidence of differences between types of day and also between monitoring zones in all the years considered in the project. The same is observed for the O3 case, but only for data coming from year 2006

Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer

Human triosephosphate isomerase (HsTIM) is a central glycolytic enzyme and is overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is highly dependent on glycolysis and is typically treated with a combination of surgery, radiation therapy, and chemotherapy. Deamidated HsTIM was recently proposed as a druggable target. Although thiol-reactive drugs affect cell growth in deamidated HsTIM-complemented cells, the role of this protein as a selective target has not been demonstrated. To delve into the usefulness of deamidated HsTIM as a selective target, we assessed its natural accumulation in breast cancer cells. We found that deamidated HsTIM accumulates in breast cancer cells but not in noncancerous cells. The cancer cells are selectively programmed to undergo cell death with thiol-reactive drugs that induced the production of methylglyoxal (MGO) and advanced glycation-end products (AGEs). In vivo, a thiol-reactive drug effectively inhibits the growth of xenograft tumors with an underlying mechanism involving deamidated HsTIM. Our findings demonstrate the usefulness of deamidated HsTIM as target to develop new therapeutic strategies for the treatment of cancers and other pathologies in which this post translationally modified protein accumulates

Diseño de estrategias conjuntas UA-centros de secundaria para el fomento del conocimiento de disciplinas científico-técnicas

Continuando con la línea emprendida por el Instituto Universitario de Ingeniería de Procesos Químicos, para desarrollar actividades de fomento del conocimiento de disciplinas de ciencia y tecnología, se ha convocado el “VI Certamen de Proyectos Educativos de Ingeniería Química” durante el curso 2013-2014. Con dicha actividad se pretende promover el interés por estudios relacionados con las disciplinas científico-técnicas, entre los alumnos de ESO, con una mejor conceptualización, comprensión y caracterización de los temas. Para ello, se diseñan, planifican y desarrollan acciones entre profesorado de la UA y centros de secundaria, sobre el papel de la Química en la industria para mejorar la calidad de vida. En la presente edición del certamen se han inscrito 13 centros, que han presentado un total de 20 proyectos, relacionados con los siguientes temas: la Ingeniería Química y el medio ambiente, la Ingeniería Química y la industria alimentaria, la Ingeniería Química y el mundo de los plásticos, la Ingeniería Química y la energía y la Ingeniería Química «Verde» sostenible

Salinity studies in Mar Menor coastal lagoon

An experiment with different AUVs was carried out in the Mar Menor Coastal Lagoon from October 31 to November 5 in order to measure and assess the influence of the water from the Mar Menor on the adjacent area of the Mediterranean. This was carried out as a result of the meeting held between several institutions from the Iberian Peninsula and EEUU (see Vilanova Marine Science/Robotics Meeting 2010). The experiment was to launch several AUVs at the same time in different zones of the Mediterranean and Mar Menor lagoon. AUVs took salinity data trying to do a coordinated mission during two operative days (November 3 and November 5). Others days of the experiment were used to the vehicle’s preparation and error correction (November 2 and November 4). This paper presents the steps followed in preparation and operative days with the set of AUVs. This paper presents also the salinity results obtained during these missions.Postprint (published version

Seroprevalence and Risk Factors Possibly Associated with Emerging Zoonotic Vaccinia Virus in a Farming Community, Colombia

In 2014, vaccinia virus (VACV) infections were identified among farmworkers in Caquetá Department, Colombia; additional cases were identified in Cundinamarca Department in 2015. VACV, an orthopoxvirus (OPXV) used in the smallpox vaccine, has caused sporadic bovine and human outbreaks in countries such as Brazil and India. In response to the emergence of this disease in Colombia, we surveyed and collected blood from 134 farmworkers and household members from 56 farms in Cundinamarca Department. We tested serum samples for OPXV antibodies and correlated risk factors with seropositivity by using multivariate analyses. Fifty-two percent of farmworkers had OPXV antibodies; this percentage decreased to 31% when we excluded persons who would have been eligible for smallpox vaccination. The major risk factors for seropositivity were municipality, age, smallpox vaccination scar, duration of time working on a farm, and animals having vaccinia-like lesions. This investigation provides evidence for possible emergence of VACV as a zoonosis in South America.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000318507https://scholar.google.com.co/citations?user=cU2KyT4AAAAJ&hl=enhttps://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000008981https://orcid.org/0000-0002-8093-054

The psychological science accelerator’s COVID-19 rapid-response dataset

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges