Sexual orientation and quality of life among students of Obafemi Awolowo University (OAU), Nigeria.

Background: Sexual orientation is an individual's pattern of physical and emotional arousal toward members of the same and/or opposite gender.Objective: To determine the pattern of sexual orientation and the relationship between sexual orientation and quality of life among a sample of OAU students.Methods: A descriptive cross sectional study among 481 students of OAU using a multistage sampling technique. They completed a Socio-demographic data schedule, questions on sexual orientation and the World Health Organization Quality of Life Scale – Brief version (WHO QOL-BREF).Results: 4.9% of the sample self-identified as bisexual while 0.1% self-identified as gay/lesbian. 11.8% of the respondents reported varying degrees of attraction to the opposite gender. The mean age of sexual debut was 17.62 (±4.05). Those who self-identified as gay/lesbian/bisexual had a lower average score on all domains of the WHO QOL-BREF.Conclusion: Same sex sexual attraction and practice occur among young people in Nigeria and this has sexual and reproductive health implications. GLB youth report a lower QOL compared to heterosexual counterparts and this may suggest some distress among this vulnerable group. More studies should be undertaken to explore issues raised in planning interventions and health services that would improve safe sexual practices within this group.Keywords: Sexual orientation, quality of life, students, Nigeria

Gene-environment interplays between family chaos and emotional problems among Nigerian adolescents: A twin study

Gene-environment correlations and interactions for the relationship between emotional problems (EP) and family environment in adolescents in low- to middle-income countries (LMIC) have been rarely investigated. In total, 3207 adolescent twins aged 12–18 (Mean = 14.6 ± 1.73) years attending public schools in Lagos State in Nigeria completed measures of EP and Family Chaos (FC). Model-fitting analyses suggested that genetic and non-shared environmental influences on EP were 21% and 71%, respectively, and the corresponding estimates were 23% and 71% for FC. Shared environmental influences were not significant (8% and 6% respectively). Phenotypic correlation between EP and FC was .30 (95% CI = .27–.34), which was significantly influenced by genetic (A – 49%, 95% CI: 0.01–0.97) and non-shared environmental factors (E – 32%, 95% CI: 0.10–0.54). Shared environmental influences were not significant (C – 19%, 95% CI: −0.13 to 0.50). Moderation effects were significant whereby as FC increased, A on EP decreased (βA = −0.07, 95% CI: −0.12 to −0.02) while E increased (βE = 0.06, 95% CI: 0.03–0.09). Our findings indicate that genetic and non-shared environmental risk factors may mediate the relationship between EP and FC, and that as FC increases, protective genetic influences on EP may be attenuated, whereas environmental influences may become stronger in adolescents in LMIC

Developmental Language Disorder and Psychopathology : Disentangling Shared Genetic and Environmental Influences

There is considerable variability in the extent to which young people with developmental language disorder (DLD) experience mental health difficulties. What drives these individual differences remains unclear. In the current paper, data from the Twin Early Development Study were used to investigate the genetic and environmental influences on psychopathology in children and adolescents with DLD (n=325) and those without DLD (n=865). Trivariate ACE models were fitted to investigate aetiological influences on DLD and psychopathology and bivariate heterogeneity and homogeneity models were fitted and compared to investigate quantitative differences in aetiological influences on psychopathology between the groups. The genetic correlation between DLD and internalising problems in childhood was significant suggesting that their co-occurrence is due to common genetic influences. Similar, but non-significant effects were observed for externalising problems. In addition, genetic influences on internalising problems, but not externalising problems, appeared to be higher in young people with DLD than those without DLD suggesting that the presence of DLD may exacerbate genetic risk for internalising problems. These findings suggest that genetic influences on internalising problems may also confer susceptibility to DLD (or vice versa) and that DLD serves as an additional risk factor for those with a genetic predisposition for internalising problems

Measurement invariance of the strengths and difficulties questionnaire across socioeconomic status and ethnicity from ages 3 to 17 years: A population cohort study

Mental health inequalities along ethnic and socioeconomic groupings are well documented. The extent to which these observed inequalities are genuine or reflect measurement differences is unclear. In the current study we sought to investigate this in a large population-based sample of children and adolescents in the United Kingdom. The main objective of the study was to establish whether the parent-report Strengths and Difficulties Questionnaire (SDQ) was invariant across ethnicity and socioeconomic status groupings at six time points from 3 to 17 years (maximum N = 17,274). First, we fitted a series of confirmatory factor analysis models to the data and confirmed that the five-factor structure (emotional problems; peer problems; conduct problems; hyperactivity/inattention; and prosocial behaviour) had acceptable fit at ages 5, 7, 11, and 14 years. Next, we tested configural, metric, and scalar invariance at these time points and demonstrated scalar invariance across household income, parent highest education, and ethnicity categories. The five-factor structure did not fit well at ages 3 and 17 years; therefore invariance was not tested at these ages. These findings suggest the parent-report SDQ can be used to measure socioeconomic and ethnic inequalities in mental health from ages 5–14 years but more consideration is required outside these ages

Developmental language disorder and psychopathology: disentangling shared genetic and environmental influences

There is considerable variability in the extent to which young people with developmental language disorder (DLD) experience mental health difficulties. What drives these individual differences remains unclear. In the current article, data from the Twin Early Development Study were used to investigate the genetic and environmental influences on psychopathology in children and adolescents with DLD (n = 325) and those without DLD (n = 865). Trivariate models were fitted to investigate etiological influences on DLD and psychopathology, and bivariate heterogeneity and homogeneity models were fitted and compared to investigate quantitative differences in etiological influences on psychopathology between those with and without DLD. The genetic correlation between DLD and internalizing problems in childhood was significant, suggesting that their co-occurrence is due to common genetic influences. Similar, but nonsignificant effects were observed for externalizing problems. In addition, genetic influences on internalizing problems, but not externalizing problems, appeared to be higher in young people with DLD than those without DLD, suggesting that the presence of DLD may exacerbate genetic risk for internalizing problems. These findings indicate that genetic influences on internalizing problems may also confer susceptibility to DLD (or vice versa) and that DLD serves as an additional risk factor for those with a genetic predisposition for internalizing problems

Sexual orientation and quality of life among students of Obafemi Awolowo University (OAU), Nigeria.

Abstract Background: Sexual orientation is an individual's pattern of physical and emotional arousal toward members of the same and/or opposite gender. Objective: To determine the pattern of sexual orientation and the relationship between sexual orientation and quality of life among a sample of OAU students. Methods: A descriptive cross sectional study among 481 students of OAU using a multistage sampling technique. They completed a Socio-demographic data schedule, questions on sexual orientation and the World Health Organization Quality of Life Scale \u2013 Brief version (WHO QOL-BREF). Results: 4.9% of the sample self-identified as bisexual while 0.1% self-identified as gay/lesbian. 11.8% of the respondents reported varying degrees of attraction to the opposite gender. The mean age of sexual debut was 17.62 (\ub14.05). Those who self-identified as gay/lesbian/bisexual had a lower average score on all domains of the WHO QOL-BREF. Conclusion: Same sex sexual attraction and practice occur among young people in Nigeria and this has sexual and reproductive health implications. GLB youth report a lower QOL compared to heterosexual counterparts and this may suggest some distress among this vulnerable group. More studies should be undertaken to explore issues raised in planning interventions and health services that would improve safe sexual practices within this group

Genetic and environmental influences on sexual orientation: moderation by childhood gender nonconformity and early-life adversity

Existing evidence indicates genetic and non-genetic influences on sexual orientation; however, the possibility of gene-environment interplay has not been previously formally tested despite theories indicating this. Using a Finnish twin cohort, this study investigated whether childhood gender nonconformity and early-life adversities independently moderated individual differences in sexual orientation and childhood gender nonconformity, the relationship between them, and the etiological bases of the proposed moderation effects. Sexual orientation, childhood gender nonconformity, and early-life adversities were assessed using standard questionnaires. Structural equation twin model fitting was carried out using OpenMx. Childhood gender nonconformity was significantly associated with reduced phenotypic variance in sexual orientation (β =  − 0.14, 95% CI − 0.27, − 0.01). A breakdown of the underlying influences of this moderation effect showed that this was mostly due to moderation of individual-specific environmental influences which significantly decreased as childhood gender nonconformity increased (βE =  − 0.38; 95% CI − 0.52, − 0.001) while additive genetic influences were not significantly moderated (βA = 0.05; 95% CI − 0.30, 0.27). We also observed that the relationship between sexual orientation and childhood gender nonconformity was stronger at higher levels of childhood gender nonconformity (β = 0.10, 95% CI 0.05, 0.14); however, significance of the underlying genetic and environmental influences on this relationship could not be established in this sample. The findings indicate that beyond a correlation of their genetic and individual-specific environmental influences, childhood gender nonconformity is further significantly associated with reduced individual-specific influences on sexual orientation

The Etiological and Predictive Association Between ADHD and Cognitive Performance From Childhood to Young Adulthood

Objective: Evidence about the etiology of the predictive associations between a diagnosis of ADHD and cognitive performance over time is scarce. Here, we examine these predictive and etiological patterns using a cross-lagged model design in a sample of 404 participants (74% males) from ADHD and control sibling pairs aged 6 to 17 years at baseline and 12 to 24 years at follow-up. Methods: Data included IQ, short-term and working memory measures, and response speed and variability from a four-choice reaction-time task. Results: ADHD and IQ predicted each other over time. ADHD at baseline predicted lower working memory performance at follow-up. Stable etiological influences emerged in the association between ADHD and cognitive variables across time. Conclusion: Whether early interventions can reduce negative interference with learning at school requires further study

Family history of twinning and fertility traits in Nigerian mothers of dizygotic twins

Familial twinning and fertility traits were investigated in Nigerian mothers of dizygotic (DZ) twins (MoDZT; N = 972) and controls (N = 525) who responded to our person-to-person interview, which included questions on pregnancy history and family history of DZ twinning. Controls were defined as women who are not twins themselves and do not have twins in their first-degree relatives. Over 95% of the participants were Yoruba. We found that Nigerian MoDZT had an average of 4.0 (±2.6) pairs of twins among their relatives, and of these, the prevalence of DZ twins was significantly higher than that of monozygotic (MZ) twins (45.9% vs. 25.8%). Controls had an average of 0.5 (±0.4) pairs, and over 95% of the controls had no twins in their relatives. These results suggest genetic influences on DZ twinning in Nigerians. MoDZT were significantly younger in their mean age at first child, and had higher parity than controls, suggesting increased fertility in MoDZT. As compared to mothers with a single set of twins, mothers (N = 130) with multiple sets had significantly more twins among their relatives (5.4 pairs vs. 3.7 pairs) and had their first twins at a younger age (28.4 vs. 30.7 years), indicating that mothers with multiple sets of twins might have higher genetic propensity for twinning associated with earlier age at twin pregnancy. Our findings argue for genomewide association studies for DZ twinning in Nigerians, and may help to develop intervention strategies to overcome infertility/subfertility problems

A cross‐lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood

Background Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle of reciprocal influences between emotional symptoms and interpersonal difficulties may explain why some adolescents suffer from persisting emotional symptoms. However, the role of different types of interpersonal difficulties, such as social isolation and peer victimisation, in these reciprocal associations is still unclear. In addition, the lack of longitudinal twin studies conducted on emotional symptoms during adolescence means that the genetic and environmental contributions to these relationships during adolescence remain unknown. Methods Participants (N = 15,869) from the Twins Early Development Study completed self-reports of emotional symptoms, social isolation and peer victimisation at 12, 16 and 21 years old. A phenotypic cross-lagged model examined reciprocal associations between variables over time, and a genetic extension of this model examined the aetiology of the relationships between variables at each timepoint. Results First, emotional symptoms were reciprocally and independently associated with both social isolation and peer victimisation over time, indicating that different forms of interpersonal difficulties uniquely contributed to emotional symptoms during adolescence and vice versa. Second, early peer victimisation predicted later emotional symptoms via social isolation in mid-adolescence, indicating that social isolation may constitute an intermediate pathway through which peer victimisation predicts longer-term emotional symptoms. Finally, individual differences in emotional symptoms were mostly accounted for by non-shared environmental factors at each timepoint, and both gene–environment and individual-specific environmental mechanisms were involved in the relationships between emotional symptoms and interpersonal difficulties. Conclusions Our study highlights the necessity to intervene early in adolescence to prevent the escalation of emotional symptoms over time and to consider social isolation and peer victimisation as important risk factors for the long-term persistence of emotional symptoms