The long term prognosis of children with hip dysplasia in aspect of ultrasound of the skeletal muscle

Die Hüftdysplasie zählt in Deutschland mit 2 bis 4% zu den häufigsten angeborenen Fehlbildungen. In den angloamerikanischen Ländern erfolgt die Diagnose überwiegend durch die klinische Untersuchung. Die frühzeitige Diagnostik ist dank der Hüftgelenkssonographie, die routinemässig im Rahmen der U3 in Deutschland seit dem 01.01.1996 durchgeführt wird, entschieden verbessert worden. Entscheidend für die Beantwortung der Frage nach der Effizienz des Sonographie-Screenings ist die Langzeitprognose der früh erfassten Kinder. Kontrolluntersuchungen werden nach Therapieabschluss einer Hüftgelenksfehlstellung im späteren Kindesalter häufig vernachlässigt. Wir haben versucht herauszufinden, ob es bei Kindern mit angeborener Hüftdysplasie der Altersgruppe 7-12 Auffälligkeiten und Unterschiede zu hüftgesunden Kindern deselben Alters gibt. Unser Hauptaugenmerk lag auf der Myosonographie der Quadricepsgruppe. Die Studie hat erfreulicherweise gezeigt, dass die ehemals hüftkranken Kinder sich gleichermassn entwickelt haben wie ihre hüftgesunden Altersgenossen. Wir haben zudem eine auffallend höhere sportliche Aktivität der ehemals hüftkranken Kinder feststellen können.Dysplasia of the hip is one of the most spread diseases in early childhood in Germany. In most western countries the diagnosis is made by clinical tests. Since 1st of January 1996, in Germany in addition to clinical tests, pediatrics make an ultrasound of the hip regularly early after birth. We tried to find out, if long term prognosis of children with former hip dysplasia, now aged 7 to 12, can be made. We especially considered the ultrasound of muscles of the quadriceps group and compared our datas to those of healthy children. Fortunately, we couldn`t find any negative aspect in comparison, but even found out, that children with former hip dysplasia do more sports than those of our healthy group of control

Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives

Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed

Crystallization Products of Risedronate with Carbohydrates and Their Substituted Derivatives

The gastrointestinal absorption of bisphosphonates is in general only about 1%. To address this problem mixtures of risedronate monosodium salt with twelve varied sugar alcohols, furanoses, pyranoses and eight gluco-, manno- and galactopyranoside derivatives as counterions were designed in an effort to prepare co-crystals/new entities with improved intestinal absorption. Crystalline forms were generated by means of kinetically and/or thermodynamically controlled crystallization processes. One hundred and fifty-two prepared samples were screened by means of FT-NIR and FT-Raman spectroscopy. No co-crystal was prepared, but noteworthy results were obtained. A new solid phase of risedronate monosodium salt generated in the presence of phenyl-β-d-galactopyranoside under thermodynamically controlled crystallization conditions was found and also characterized using solid state NMR spectroscopy, X-ray powder diffraction and differential scanning calorimetry. This new polymorph was named as form P. Interactions between risedronate monosodium salt and both carbohydrates were confirmed by means of molecular dynamics simulation. In the present study the relationships between the chemical structures of the studied compounds required for crystalline form change are discussed