Radiation induced broncıolitis obliterans organizing pneumonia (BOOP) syndrome after radiotherapy for breast cancer

Radyasyona bağlı bronşiolitis obliterans organize pnömoni (BOOP) sendromu patolojik olarak bronşiol ve alveoler kanallarda granülasyon dokusu polipleri ve organize pnömoni yamalı alanları ile karakterize bir akciğer hastalığıdır. İdiopatik gelişebileceği gibi infeksiyon, ilaç reaksiyonları, kollajen vasküler hastalıklar, hipersensitivite pnömonisi, toksik gaz inhalasyonu, akut solunumsal yetmezlik sendromu, tiroidit ve radyoterapi de etyolojik nedenler arasında sayılabilir. Işınlanan akciğer dokusunda görülen radyasyon pnömonisinden farklı olarak alan dışında ve her iki akciğerde de görülebilen bu hastalıkta radyoterapi sahası içinde kalan akciğer ve plevral dokudaki lenfosit stimülasyonu ve salgılanan sitokinlere bağlı aşırı duyarlılık mekanizması sorumlu tutulmaktadır. Erken evre meme kanseri nedeniyle meme koruyucu cerrahi ile postoperatif radyoterapi uygulanmış ve iki akciğerinde toksisite gelişmiş bir olgumuz sunulacaktır.Radiation-induced bronchiolitis obliterans organising pneumonia (BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia. Etiologic factors include infection, drug administration, collagen vascular disease, hypersensitivity pneumonia, toxic fume inhalation, acute respiratory deficiency syndrome, thyroiditis and radiotherapy and it may also develop idiopathic. Occurence of radiation injury in the lung outside the tangential fields and appearance of patchy infiltrates in both lungs are characteristic. It is assumed that radiation exposure to lung and pleura initiates a lymphocytic stimulation which then triggers a cytokin mediated immunologic reaction and causes the injury in both lungs. We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs

RADIATION INDUCED BRONCIOLITIS OBLITERANS ORGANIZING PNEUMONIA (BOOP) SYNDROME AFTER RADIOTHERAPY FOR BREAST CANCER

Radiation-induced bronchiolitis obliterans organising pneumonia ( BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia. Etiologic factors include infection, drug administration, collagen vascular disease, hypersensitivity pneumonia, toxic fume inhalation, acute respiratory deficiency syndrome, thyroiditis and radiotherapy and it may also develop idiopathic. Occurence of radiation injury in the lung outside the tangential fields and appearance of patchy infiltrates in both lungs are characteristic. It is assumed that radiation exposure to lung and pleura initiates a lymphocytic stimulation which then triggers a cytokin mediated immunologic reaction and causes the injury in both lungs. We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs

Dosimetry and acute toxicity in prostate cancer patients treated with image-guided intensity modulated radiotherapy: preliminary results in the first 100 men

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Amaç: Lokalize prostat kanseri olgularında uygulanan görüntü rehberliğinde yoğunluk ayarlı radyoterapinin (YART) dozimetrik ölçütlerini ve erken dönem akut yan etkilerini araştırmak amacıyla ilk 100 olgunun dosyaları retrospektif olarak incelendi. Gereç Ve Yöntem: Görüntü rehberliği amacıyla her olguda prostat içersine transüretral ultrason eşliğinde üç adet altın marker yerleştirildi, her tedavi öncesi bu markerların lokalizasyonu verifiye edildikten sonra radyoterapi uygulandı. Olguların risk gruplarına göre prostat +/- seminal veziküller +/- pelvik lenf nodları klinik hedef volüme dahil edildi. Hedef volüme ortanca 76 Gy (aralık, 74-78 Gy) radyoterapi uygulandı. Tedavi sonrası en az üç ay takip edilen olgular tedavi sırasında her hafta, tedavi sonrasında da 1. ayda akut toksisite açısından değerlendirildi ve akut yan etkiler RTOG skorlamasına göre derecelendirildi.Objectives: We aimed to analyze the dosimetric criteria and preliminary acute toxicity in the first 100 men treated with image-guided intensity modulated radiotherapy (IG-IMRT) for localized prostate cancer. Methods: For image guidance, three fiducial gold markers were implanted in each patient under transurethral ultrasound guidance. According to the risk group classification, prostate and/or seminal vesicles and/or pelvic lymph nodes were defined as the clinical target volume. A median of 76 Gy (range, 74-78 Gy) was delivered to the planning target volume. The patients were evaluated once a week during the treatment and one month after the completion of the treatment. Acute toxicity was scored according to the RTOG scoring system

Replacement of tumor bed after oncoplastic breast-conserving surgery with immediate latissimus dorsi mini-flap

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Oncoplastic breast-conserving surgery satisfies oncologic principles of negative margins and improves cosmetic outcomes, even if excision of a considerably large breast volume is required. During this surgical procedure quadrantectomy cavity is filled by the latissimus dorsi mini-flap which might shift tumor bed. The purpose of this study is to evaluate geographic variability after this procedure and its relevance to radiation therapy planning.http://www.redjournal.org/article/S0360-3016(14)01490-4/fulltex