Effects of restricted feeding and re-alimentation of dietary protein or energy on compensatory growth of sheep

The study investigated the effects of re-alimenting dietary protein or energy on growth, carcass characteristics and meat eating quality parameters of sheep. Twenty-seven intact rams (~9 months; 11.3 ± 0.5 kg) were randomly divided into three groups. Each group was fed a maintenance diet (MT) containing, on dry matter (DM) basis, 105 g/kg crude protein (CP) and 8.4 MJ/kg DM metabolizable energy (ME) for 30 days. Thereafter, they were continually fed the same MT or re-alimented with a high protein diet (HP) containing 169 g/kg DM CP and 9.3 MJ/kg ME or a high energy diet (HE) containing 123 g/kg DM CP and 10.6 MJ/kg ME for an additional 30 days to determine the effects of re-alimentation of protein or energy on their growth performance and carcass characteristics. During the initial 30-day period, DM intake (DMI) and growth performance were similar among the three groups. However, upon re-alimentation, average daily gain (ADG) and feed efficiency of sheep re-alimented with HP were greater than those maintained continually on MT or re-alimented with HE. Sheep on HP had higher feed efficiency, ADG and heavier carcasses than those fed MT or re-alimented with HE during the whole 60-day period. Growth of most viscera was less responsive to the restriction-re-alimentation feeding regimen except for the weights of the lungs, heart and intestines. Meat from sheep re-alimented with HE had a more intense ‘sheepy’ flavour than those fed MT or re-alimented with HP, but juiciness and tenderness were not affected. The higher ADG of sheep re-alimented with protein may be related more to enhanced efficiency of feed utilization than to higher DMI.Keywords: average daily gain, feed restriction, nutrient utilization efficiency, visceral organ

Long discontinuous fiber composite structure: Forming and structural mechanics

Cost effective composite structure has motivated the investigation of several new approaches to develop composite structure from innovative material forms. Among the promising new approaches is the conversion of planar sheet to components of complex curvature through sheet forming or stretch forming. In both cases, the potential for material stretch in the fiber direction appears to offer a clear advantage in formability over continuous fiber systems. In the present study, the authors have established a framework which allows the simulation of the anisotropic mechanisms of deformation of long discontinuous fiber laminates wherein the matrix phase is a viscous fluid. The initial study focuses upon the establishment of micromechanics models for prediction of the effective anisotropic viscosities of the oriented fiber assembly in a viscous matrix. Next, the developed constitutive relation is employed through an analogy with incompressible elasticity to exercise the finite element technique for determination of local fiber orientation and laminate thickness after forming. Results are presented for the stretch bending of a curved beam from an arbitrary composite laminate and the bulging of a clamped sheet. Structural analyses are conducted to determine the effect of microstructure on the performance of curved beams manufactured from long discontinuous fiber composites. For the purposes of this study, several curved beams with ideal and non-ideal microstructures are compared for response under pure bending. Material parameters are determined from a separate microstructural analysis

Physicochemical and Microbial Assessment of Borehole Water on the Campus of KNUST and its Satellite Towns of Ayeduase and Kotei

ABSTRACT In developing countries boreholes are economically viable option for water production and supplies for domestic and general use. Ground waters are generally considered as 'safe sources' of drinking water because they are produced with low microbial load with little need for treatment of the water before drinking .A physicochemical and microbial analysis of drinking water from six (6) different boreholes on the campus of the Kwame Nkrumah University of Science and Technology (KNUST) and two of its satellite communities; Ayeduase and Kotei was undertaken. The principal aims were to ascertain the wholesomeness of the water by assessing the level of microbes as well as the faecal matters and total coliform and to determine and compare the levels of major elements in the water with international standards. All the water samples passed the physical and chemical tests conducted, except for the pH test which most of the samples failed. The levels of trace metals determined were all below the WHO guideline levels. Only Unity Hall Borehole, UHB and Ayeduase Borehole 1, AB1 failed the microbial test using Mannitol Salt Agar and Bismuth Sulphite Agar respectively. With the exception of the control, all the water samples failed the total and true coliform test

Winter Grazing and Feeding Systems in Western Canada

Beef cow calf producers in Western Canada are looking for methods of extending the grazing season into the winter in order to lower winter feed costs. Dry beef cows were early or late weaned and grazed during the early months of winter on late seeded barley swaths (Hardlum vulgare L.) and compared to cows fed barley silage and free choice barley straw in a feeding yard. The swath grazed barley was late seeded in June and swathed in the silage stage in mid September. Cows successfully swath grazed for three winters from mid November until mid to late February with no major differences in animal performance The swath grazing system has less labour, less stored feeding and handling costs and less manure hauling costs than cows wintered on stored feeds in a feeding yard

Estimating the frequency of trains approaching red signals: A case study for improving the understanding of SPAD risk

This paper describes a novel technique for estimating the frequency with which trains approach signals showing a red aspect. This knowledge is potentially important for understanding the likelihood of a signal being passed at danger (SPAD) at individual signals and also for normalisation of SPAD data, both locally and nationally, for trending and benchmarking. The industry currently uses estimates for the number of red aspect approaches based on driver surveys which are considered to have significant shortcomings. Data for this analysis is sourced from publicly available live feeds provided by Network Rail which give information on train movements and signal states. The development of the analysis model and supporting software are described and some sample results from case studies are presented. An initial study of seven signalling areas showed that approximately 3.3% of all signal approaches are to red signals. However, it also highlighted that there is a large variation in the red approach rates between signalling areas and between individual signals. SPAD risk assessment at individual signals may be significantly enhanced by the ability to estimate red approach rates for individual signals using the techniques described

Dynamic regulation of the endocannabinoid system: implications for analgesia

The analgesic effects of cannabinoids are well documented, but these are often limited by psychoactive side-effects. Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. Changes in this receptor system include altered expression of receptors, differential synthetic pathways for endocannabinoids are expressed by various cell types, multiple pathways of catabolism and the generation of biologically active metabolites, which may be engaged under different conditions. This review discusses the evidence that pain states alter the endocannabinoid receptor system at key sites involved in pain processing and how these changes may inform the development of cannabinoid-based analgesics

Clinical characteristics of males with systemic lupus erythematosus (SLE) in an inception cohort of patients in Ghana

Background: Systemic Lupus Erythematosus (SLE) is said to be rare in Sub-Saharan Africa and even rarer in males worldwide. SLE is mostly considered a disease of women, though men may also be affected, and this may lead to a delay in diagnosis in men. The result is a greater burden of inflammation and subsequent organ damage over time. Method: Data from the medical records of 13 male patients diagnosed with SLE at the Rheumatology Clinic of Korle-Bu Teaching Hospital between January 2014 and January 2017 was retrospectively analyzed. Results: A total of 13 male patients out of a total of 134 SLE patients were included in our analysis. The mean age was 30.62 ± SD 8.47 years (range of 17 to 46 years). All of them (100%) presented with constitutional features. The most common ACR criteria observed was 61.5 % rash, 54.5 % oral ulcers, 92.3% arthritis, 61.5 % serositis and 38.5% renal involvement, 46.2 % CNS involvement. Looking at their serological profile, 91.7 % had a positive antinuclear antibody (ANA). 33.3 % had positive anti-dsDNA and 58.3 % extractable nuclear antigens. The mean duration from onset of symptoms to diagnosis was 21.31 months. Five patients were diagnosed with lupus nephritis, all at the time of diagnosis. There were no mortalities. Conclusion: Male SLE patients in Ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis being the main early indicator of organ damage. This should warrant aggressive management in male patients. Funding: None declared Keywords: Male, systemic lupus erythematosus, nephritis, Sub-Saharan Afric

CALMS: Modelling the long-term health and economic impact of Covid-19 using agent-based simulation

Data Availability Statement: All data files are available from https://doi.org/10.17633/rd.brunel.19350518 The software is available on https://gitlab.com/anabrunel/calms.Copyright: © 2022 Mintram et al. We present our agent-based CoronAvirus Lifelong Modelling and Simulation (CALMS) model that aspires to predict the lifelong impacts of Covid-19 on the health and economy of a population. CALMS considers individual characteristics as well as comorbidities in calculating the risk of infection and severe disease. We conduct two sets of experiments aiming at demonstrating the validity and capabilities of CALMS. We run simulations retrospectively and validate the model outputs against hospitalisations, ICU admissions and fatalities in a UK population for the period between March and September 2020. We then run simulations for the lifetime of the cohort applying a variety of targeted intervention strategies and compare their effectiveness against the baseline scenario where no intervention is applied. Four scenarios are simulated with targeted vaccination programmes and periodic lockdowns. Vaccinations are targeted first at individuals based on their age and second at vulnerable individuals based on their health status. Periodic lockdowns, triggered by hospitalisations, are tested with and without vaccination programme in place. Our results demonstrate that periodic lockdowns achieve reductions in hospitalisations, ICU admissions and fatalities of 6-8% compared to the baseline scenario, with an associated intervention cost of £173 million per 1,000 people and targeted vaccination programmes achieve reductions in hospitalisations, ICU admissions and fatalities of 89-90%, compared to the baseline scenario, with an associated intervention cost of £51,924 per 1,000 people. We conclude that periodic lockdowns alone are ineffective at reducing health-related outputs over the long-term and that vaccination programmes which target only the clinically vulnerable are sufficient in providing healthcare protection for the population as a whole.EU Horizon 2020 STAMINA project No. 883441 (https://cordis.europa.eu/project/id/883441)

FACS-CHARM: A Hybrid Agent-Based and Discrete-Event Simulation Approach for Covid-19 Management at Regional Level

10.13039/100010661-EU H2020 STAMINA (Grant Number: 883441