5 research outputs found
Refining Coarse-grained Spatial Data using Auxiliary Spatial Data Sets with Various Granularities
We propose a probabilistic model for refining coarse-grained spatial data by
utilizing auxiliary spatial data sets. Existing methods require that the
spatial granularities of the auxiliary data sets are the same as the desired
granularity of target data. The proposed model can effectively make use of
auxiliary data sets with various granularities by hierarchically incorporating
Gaussian processes. With the proposed model, a distribution for each auxiliary
data set on the continuous space is modeled using a Gaussian process, where the
representation of uncertainty considers the levels of granularity. The
fine-grained target data are modeled by another Gaussian process that considers
both the spatial correlation and the auxiliary data sets with their
uncertainty. We integrate the Gaussian process with a spatial aggregation
process that transforms the fine-grained target data into the coarse-grained
target data, by which we can infer the fine-grained target Gaussian process
from the coarse-grained data. Our model is designed such that the inference of
model parameters based on the exact marginal likelihood is possible, in which
the variables of fine-grained target and auxiliary data are analytically
integrated out. Our experiments on real-world spatial data sets demonstrate the
effectiveness of the proposed model.Comment: Appears in Proceedings of the Thirty-Third AAAI Conference on
Artificial Intelligence (AAAI 2019
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress
Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes were expressed at higher levels in the aged human retina suggesting increased activity of hypoxia-inducible transcription factors (HIFs) during the physiological ageing process. To model chronically elevated HIF activity and investigate ensuing consequences for photoreceptors, we generated mice lacking von Hippel Lindau (VHL) protein in rods. This activated HIF transcription factors and led to a slowly progressing retinal degeneration in the ageing mouse retina. Importantly, this process depended mainly on HIF1 with only a minor contribution of HIF2. A gene therapy approach using AAV-mediated RNA interference through an anti-Hif1a shRNA significantly mitigated the degeneration suggesting a potential intervention strategy that may be applicable to human patients
深層点過程を用いた時空間イベント予測
京都大学新制・課程博士博士(情報学)甲第24028号情博第784号新制||情||133(附属図書館)京都大学大学院情報学研究科知能情報学専攻(主査)教授 鹿島 久嗣, 教授 山本 章博, 教授 吉川 正俊学位規則第4条第1項該当Doctor of InformaticsKyoto UniversityDFA