73 research outputs found
Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
Classification of the nucleolytic ribozymes based upon catalytic mechanism
The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2â-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater. A major part of this arises from concerted general acid-base catalysis. Recent identification of new ribozymes has expanded the group to a total of nine and this provides a new opportunity to identify sub-groupings according to the nature of the general base and acid. These include nucleobases, hydrated metal ions, and 2â-hydroxyl groups. Evolution has selected a number of different combinations of these elements that lead to efficient catalysis. These differences provide a new mechanistic basis for classifying these ribozymes
Preparation of pyrimidine 5â-O-beta-D-ribofuranosyl nucleosides. Hydrolytic stability of O-D-ribofuranosyl nucleosides
status: publishe
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