The Enthalpy of Formation of Terbium Trifluoride by Fluorine Bomb Calorimetry

The energy of formation of terbium trifluoride has been measured by a direct fluorination of terbium metal with fluorine gas in a bomb calorimeter, giving a value of -(1698±14) KJ mol⁻¹. From this value, the standard enthalpy of formation of TbF₃ (c) is deduced as -(1701±14) kj mol⁻¹, and the standard Gibbs energy of formation of TbF₃ (c) is calculated to be -(1623±14) kj mol⁻¹, using estimates for the entropy. These values should be considered as being tentative

Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals

Diversity of conserved pancRNA expression profile of the five tissues in the five species. Hierarchical clustering and symmetrical heat map of Spearman correlation coefficients of conserved pancRNA (A) and their corresponding mRNA (B) expression profiles. Samples are colored according to the tissues and the species. (PDF 301 kb

The potential hazard of a non-slip element balloon causing distal longitudinal stent deformation: the first clinical experience and in vitro assessment

Background: A new complication, longitudinal stent deformation (LSD), is increasingly reported withrecent intracoronary stent designs. There have been experiences of unusual cases of distal LSD causedby entrapment of a Lacrosse® non-slip element (NSE) balloon (Goodman Co., Ltd., Nagoya, Japan),which has three flexible nylon elements to prevent slippage. Accordingly, the aim of this study is to reportthe clinical experience of distal LSD caused by the NSE in the documented center and to investigate theincidence and mechanisms involved.Methods: Coronary intervention cases were retrospectively reviewed using the NSE balloon in hospitalbetween May 2014 and June 2017. In bench testing, distal LSD was reproduced in a silicon tube modelto identify its mechanism.Results: A total of 95 patients with 107 lesions underwent coronary interventions with NSE. Of these,72 lesions (12 de-novo lesions and 60 in-stent restenosis) were treated using in-stent dilatation. Twodistal LSD cases occurred, representing an incidence of 2.78% (2/72) among all procedures; 16.7%(2/12) of the de-novo lesions developed LSD. In vitro experimentation allowed indentification of themechanisms involved and bailout strategies.Conclusions: This is the first study to evaluate NSE balloon catheter entrapment complicated by distalLSD in which reconstruction of the deformed stent and retrieval of the NSE could be achieved successfully.There is a potential hazard for distal LSD during post-dilatation using the NSE balloon due to itsstructural characteristics. Careful assessment is needed to prevent this complication

Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma

13301甲第5145号博士（医学）金沢大学博士論文要旨Abstract 以下に掲載：Cancer Medicine 9(11) pp.3904-3917 2020. John Wiley & Sons Ltd. 共著者：Masahiro Oishi, Seiichi Munesue, Ai Harashima, Mitsutoshi Nakada, Yasuhiko Yamamoto, Yasuhiko Hayash

アクティブ・ラーニングを取り入れた効果的な授業づくりに関する研究：「教職論」の授業考察を通して

アクティブ・ラーニングを取り入れた能動的な学修、学修者の学びの深まり、学びの質の向上を実現する授業デザインが授業改善の課題となっている。そのため、本稿では、アクティブ・ラーニングを取り入れた効果的な授業づくりについての検討をおこなった。具体的には、アクティブ・ラーニングを取り入れることがなぜ必要なのか、どのようなアクティブ・ラーニングをどう取り入れるのか、効果的な授業ではどのような学習成果を求めるのかを検討した。このような、観点から、授業実践（「教職論」対象1 年生2016 年実施）を取り上げ、アクティブ・ラーニングを取り入れた効果的な授業について考察をおこなった。考察では、学びの質の深まりを図る上で、アクティブ・ラーニングを効果的に取りいれるいくつかのポイントを確かめることができた。授業内容、授業学年等により、効果的な授業デザインのバリエーションが求められる。学修者の学びの質の深まりを評価することの必要性と、その手立ての一つとして、ポートフォリオ評価を取り入れることの効果についても考察した。Of the learning of active learning, learner which adopted active learning deepen, and it is a problem of improving it a class a class design realizing improvement of the quality of the learning. Therefore, in this report, I performed the examination about the making of effective class that adopted active learning. Specifically, I examined it what kind of active learning you took in how why it was necessary to adopt active learning what kind of learning result you demanded by the effective class. From such a point of view, I took up class practice（first grader 2016 enforcement targeted for “a teaching profession theory”）and considered the effective class that adopted active learning. I was able to check some points to adopt active learning effectively in planning deepening of the quality of the learning for the consideration. By class contents, a class school year, the variation of the effective class design is found. I considered the effect of taking in a portfolio evaluation as need of evaluating deepening of thequality of the learning of the learner and one of the means

Laparoscopic total colectomy with lymph node dissection for familial adenomatous polyposis with multiple colorectal cancers

　A 49-year-old Japanese man visited our hospital with chief complaints of difficulty with and bleeding during defecation. After a detailed examination, he was diagnosed with familial adenomatous polyposis (FAP) with multiple (five) colorectal cancers. The tumors were located in the right-sided, left-sided, and sigmoid colon, and the lower rectum. Regional lymph node involvement was observed, but no metastasis to other organs was detected. We, therefore, performed a laparoscopic total colectomy with superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) lymph node dissection. We were able to perform minimally invasive and cosmetically acceptable surgery using laparoscopy instead of highly-invasive open abdominal surgery. Our search of the literature revealed no reported cases of laparoscopic total colectomy with lymph node dissection for FAP with multiple colorectal cancers, making the present case the first to be reported in the literature

Phencyclidine and the Dynamics of Mouse Brain Histamine

ABSTRAC

Bilateral Orbital Inflammation as a Manifestation of Paraneoplastic Syndrome

Paraneoplastic neurologic syndromes (PNS) constitute a rare group of disorders whose optimal treatment is yet to be established. We report a patient with bilateral orbital inflammation associated with PNS, who responded well to surgical resection of the primary tumor. An 83-year-old woman was referred to our department for treatment of a progressive reduction in visual acuity and palpebral swelling in both eyes for the past 2 months. She was scheduled to undergo thoracic surgery for lung cancer. The best-corrected visual acuity (BCVA) in the right and left eye had worsened from 0.3 to 0.5 one month before she was referred to our department to 0.03 and 0.07, respectively. A slit-lamp examination revealed edema in both eyelids. Goldmann perimetry revealed several paracentral scotomas with constriction of the peripheral visual fields of both eyes, along with central absolute scotomas in V-4e isopter in the right eye. Magnetic resonance imaging revealed swelling of the bilateral extraocular muscles, which compressed the bilateral optic nerves at the orbital apex. Seven days after the resection of the lung cancer, the BCVA improved to 0.07 and 0.15 in the right and left eyes, respectively, without concomitant immunotherapy. Intravenous methylprednisolone (500 mg/day) was administered for 3 days to treat the residual orbital inflammation. Fourteen days after surgery, the BCVA further improved to 0.4 and 0.5 in the right and left eyes, respectively. Swelling of the bilateral extraocular muscles and the visual field abnormalities improved dramatically. Early diagnosis is crucial for the management of PNS

Reorganization of Corticospinal Projections after Prominent Recovery of Finger Dexterity from Partial Spinal Cord Injury in Macaque Monkeys

We investigated morphologic changes in the corticospinal tract (CST) to understand the mechanism underlying recovery of hand function after lesion of the CST at the C4/C5 border in seven macaque monkeys. All monkeys exhibited prominent recovery of precision grip success ratio within a few months. The trajectories and terminals of CST from the contralesional (n = 4) and ipsilesional (n = 3) hand area of primary motor cortex (M1) were investigated at 5–29 months after the injury using an anterograde neural tracer, biotinylated dextran amine (BDA). Reorganization of the CST was assessed by counting the number of BDA-labeled axons and bouton-like swellings in the gray and white matters. Rostral to the lesion (at C3), the number of axon collaterals of the descending axons from both contralesional and ipsilesional M1 entering the ipsilesional and contralesional gray matter, respectively, were increased. Caudal to the lesion (at C8), axons originating from the contralesional M1, descending in the preserved gray matter around the lesion, and terminating in ipsilesional Laminae VI/VII and IX were observed. In addition, axons and terminals from the ipsilesional M1 increased in the ipsilesional Lamina IX after recrossing the midline, which were not observed in intact monkeys. Conversely, axons originating from the ipsilesional M1 and directed toward the contralesional Lamina VII decreased. These results suggest that multiple reorganizations of the corticospinal projections to spinal segments both rostral and caudal to the lesion originating from bilateral M1 underlie a prominent recovery in long-term after spinal cord injury