Comparaisons des exigences d’équilibre dynamique lors de la négociation de l’escalier et d’un plan incliné chez les personnes en santé

Inclined planes and stairs are current in the environment and represent a barrier for seniors and people with mobility problems. Slower progression, alteration in gait pattern likely explains the high rate of fall on these surfaces, but their effect on balance is not well known. Our objective was thus to compare the difficulty in maintaining dynamic stability during the ascent and descent of an inclined plane and stairs at natural and slow walking speed in healthy individuals. Ten young healthy participants ascended and descended an inclined plane and stairs, instrumented with force- platforms to record ground reaction forces. Whole-body kinematics was also recorded to determine balance difficulty using the stabilizing and destabilizing forces, center of mass velocity and step length. Analyses of variance were used to compare the effect of surface (inclined plane vs. stairs), direction (ascent vs. descent) and speed (natural vs. slow). The stabilizing force was higher on the inclined plane than on the stairs, with a higher velocity of the center of mass. Stabilizing force was higher and destabilizing force was lower during descent than ascent only in the inclined plane but destabilizing force was lower during ascent than descent on the stairs. Slower gait speed reduced balance difficulty on both surfaces. Step length was shorter in the stairs than on the inclined plane, and particularly during descent, and at slow gait speed. Balance difficulty was higher on the inclined plane than on the stairs and at natural speed than at slow speed. The effect of direction was opposite between surfaces with higher difficulty during descent of the inclined plane, but during ascent of the stairs. Further studies are necessary in older adults or individuals with balance deficits.La présence d’un escalier ou d’un plan incliné constitue souvent un obstacle sérieux à la réalisation des habitudes de vie des personnes ayant des incapacités physiques et même chez les personnes âgées. L’objectif général de cette étude était de quantifier l’équilibre dynamique lors de la négociation (montée et descente) d’un escalier et d’un plan incliné chez des sujets en santé. Dix sujets en santé ont été recrutés pour participer à l’évaluation. Les participants ont effectué la montée et la descente du plan incliné et de l’escalier à vitesse naturelle puis à vitesse lente. L’évaluation a compris un enregistrement de la cinématique de l’ensemble du corps. L’ensemble des données ont servi à analyser la force déstabilisante, la force stabilisante, la vitesse du centre de masse et la longueur de pas. Des ANOVAs et des tests t de Student ont permis de comparer l’effet de la surface (plan incliné vs. Escalier), de la direction (montée vs. Descente) et de la vitesse (naturelle vs. lente). La force stabilisante était plus élevée sur le plan incliné qu’à l’escalier, avec une vitesse de centre de masse plus élevée. La force stabilisante était plus élevée et la force déstabilisante était plus basse durant la descente en comparaison avec la montée sur le plan incliné. Par contre, à l’escalier, la force déstabilisante était plus basse lors de la montée en comparaison avec la descente. La vitesse de marche lente a réduit la difficulté en termes d’équilibre sur les deux surfaces. Les pas étaient plus courts sur l’escalier en comparaison avec le plan incliné, particulièrement lors de la descente à vitesse naturelle. L’effet de direction était opposé entre les surfaces, avec une difficulté plus élevée durant la descente du plan incliné et durant la montée de l’escalier. Des études approfondies seront nécessaires chez les personnes âgées et les personnes ayant des déficits de la balance

Prevention Focus Relates to Performance on a Loss-Framed Inhibitory Control Task

Information framing can be critical to the impact of information and can affect individuals differently. One contributing factor is a person’s regulatory focus, which describes their focus on achieving gains vs. avoiding losses. We hypothesized that alignment between individual regulatory focus and the framing of performance feedback as either gain or loss would enhance performance improvements from computer-based training. We measured participants’ (N = 93) trait-level regulatory focus; they then trained in a go/no-go inhibitory control task with feedback framed as gains, losses, or control feedback conditions. Some changes in performance with training (correct rejection rate and response time) were consistent with regulatory fit, but only in the loss-framed condition. This suggests that regulatory fit is more complex than cursory categorization of trait regulatory focus and feedback framing might indicate. Regulatory fit, feedback framing, and task affordances should be considered when designing feedback or including game-like feedback elements to aid computer-based training

HDL Apolipoprotein A-I Attenuates Oxidative Modification of Low Density Lipoprotein: Studies in Transgenic Mice

Peer Reviewe

The role of tank-treading motions in the transverse migration of a spheroidal vesicle in a shear flow

The behavior of a spheroidal vesicle, in a plane shear flow bounded from one side by a wall, is analysed when the distance from the wall is much larger than the spheroid radius. It is found that tank treading motions produce a transverse drift away from the wall, proportional to the spheroid eccentricity and the inverse square of the distance from the wall. This drift is independent of inertia, and is completely determined by the characteristics of the vesicle membrane. The relative strength of the contribution to drift from tank-treading motions and from the presence of inertial corrections, is discussed.Comment: 16 pages, 1 figure, Latex. To appear on J. Phys. A (Math. Gen.

Insulin Detemir in the Treatment of Type 1 and Type 2 Diabetes

Insulin detemir is a soluble long-acting human insulin analogue at neutral pH with a unique mechanism of action. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain, thereby providing slow absorption and a prolonged metabolic effect. Insulin detemir has a less variable pharmacokinetic profile than insulin suspension isophane or insulin ultralente. The use of insulin detemir can reduce the risk of hypoglycemia (especially nocturnal hypoglycemia) in type 1 and type 2 diabetic patients. However, overall glycemic control, as assessed by glycated hemoglobin, is only marginally and not significantly improved compared with usual insulin therapy. The weight gain commonly associated with insulin therapy is rather limited when insulin detemir is used. In our experience, this new insulin analogue is preferably administrated at bedtime but can be proposed twice a day (in the morning and either before the dinner or at bedtime). Detemir is a promising option for basal insulin therapy in type 1 or type 2 diabetic patients

Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes

BACKGROUND: Patient-reported measures can be used to examine whether drug differences other than clinical efficacy have an impact on outcomes that may be important to patients. Although exenatide and insulin glargine appear to have similar efficacy for treatment of type 2 diabetes, there are several differences between the two treatments that could influence outcomes from the patient's perspective. The purpose of the current study was to examine whether the two drugs were comparable as assessed by patient-reported outcomes using data from a clinical trial in which these injectable medications were added to pre-existing oral treatment regimens. METHODS: Patients were randomized to either twice daily exenatide or once daily insulin glargine during a 26-week international trial. At baseline and endpoint, five patient-reported outcome measures were administered: the Vitality Scale of the SF-36, The Diabetes Symptom Checklist – Revised (DSC-R), the EuroQol EQ-5D, the Treatment Flexibility Scale (TFS), and the Diabetes Treatment Satisfaction Questionnaire (DTSQ). Change from baseline to endpoint was analyzed within each treatment group. Group differences were examined with General linear models (GLMs), controlling for country and baseline scores. RESULTS: A total of 549 patients with type 2 diabetes were enrolled in the trial, and current analyses were conducted with data from the 455 per protocol patients (228 exenatide and 227 insulin glargine). The sample was primarily Caucasian (79.6%), with slightly more men (55.2%) than women, and with a mean age of 58.5 years. Paired t-tests found that both treatment groups demonstrated statistically significant baseline to endpoint change on several of the health outcomes instruments including the DSC-R, DTSQ, and the SF-36 Vitality subscale. GLMs found no statistically significant differences between groups in change on the health outcomes instruments. CONCLUSION: This analysis found that both exenatide and insulin glargine were associated with significant improvements in patient-reported outcomes when added to oral medications among patients with type 2 diabetes. Despite an additional daily injection and a higher rate of gastrointestinal adverse events, treatment satisfaction in the exenatide group was comparable to that of the glargine group, possibly because of weight reduction observed in patients treated with exenatide