Effects of a lifestyle counselling intervention on adherence to lifestyle changes 7 years after stroke - A quasi-experimental study

Background Adherence to medication and healthy lifestyle is crucial for preventing secondary strokes and other vascular events. However, there is not enough evidence on the long-term effects of hospital-initiated lifestyle counselling. Aim To determine the effects of The Risk Factor Targeted Lifestyle Counselling Intervention, which is implemented during acute hospitalisation, on adherence to lifestyle changes 7 years after stroke or TIA. Methods Quasi-experimental design with 7-year follow-up period. Baseline data (n = 150) were gathered from a neurology unit in Finland between 2010 and 2011. Patients received either the studied intervention (n = 75) or the prevailing form of counselling at the time (n = 75). Data concerning lifestyle and clinical values were measured at the baseline time point, while adherence to lifestyle changes was assessed 7 years later (2017-2018). Analysis of covariance and multivariate ordinal logistic regression were used to describe the mean differences between the intervention and control groups. Results Several between-group differences were detected, namely, members of the intervention group reported consuming less alcohol and having lost more weight during hospitalisation relative to the control group. No between-group differences in the prevalence of smokers were found, but the intervention group reported a greater number of daily cigarettes than the control group. Adherence to medication, importance of adherence to a healthy lifestyle, support from family and friends, and support from nurses were all significantly higher in the intervention group than in the control group. Conclusions The results suggest that the lifestyle counselling intervention was effective in decreasing alcohol use and weight, as well as increasing factors that are known to support adherence to a healthy lifestyle. Relevance to clinical practice The results indicate that the adherence process already begins during acute phase counselling. To ensure long-lasting lifestyle changes, counselling should be started at the hospital, after which it can be provided by friends and family members.</p

Yrittäjyyskasvatus – Tulevaisuuden siltojen rakentaja ja raja-aitojen murtaja? 11. Yrittäjyyskasvatuspäivät 2017 Oulussa, Artikkelikirja

The aim of this project was to create a preliminary theoretical framework of howto utilize humour strategically in organizations with the aim of creating newbusiness opportunities. The present multidisciplinary discussion paper will identifyresearch gaps and combine viewpoints of international business management,international business communication, marketing and education in a novel way. Itappears that in previous literature on humour in a business context, discussionshave taken place in different ‘silos’ and as a result, the connections betweendifferent research fields have been scarce. Consequently, a more comprehensiveunderstanding of the significance of humour in business innovations is necessary.Firstly, we are proposing a framework and a research agenda for exploring differentstrategic ways of using humour in companies. Secondly, in the Hurmos-project wehave already collected empirical evidence based on this framework, and somepreliminary results are also presented. Hence, the potential, as well as the limitsand risks of humour in business have been examined in terms of both internal andexternal corporate communication. We have focused on such research aspects ascorporate storytelling, corporate and employer branding, and work engagement.Peer group mentoring has been used as one tool for collecting relevant narrativesfrom companies. Additionally, we have explored innovation communication, inparticular how humour can be applied as a strategic tool in new businessdevelopment both in facilitating creative Research, Development and Innovation(R&D&I) work environments, and in incorporating humour into product andservice innovation in practice. Our empirical results will provide a much neededmore comprehensive view of the role of humour as a strategic tool in corporatecommunication and business innovation. The results also provide a point of departure for further research. Besides academia, results and generated know-how will be of interest to managers of large corporations as well as start-up companies.</p

Airway Epithelial Cell Migration Dynamics: Mmp-9 Role in Cell–Extracellular Matrix Remodeling

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We investigated the location of MMP-9 and its potential role in migrating human bronchial epithelial cells (HBEC). In vivo and in vitro, MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and MMP-9 expression paralleled cell migration speed. MMP-9 accumulated through an actin-dependent pathway in the advancing lamellipodia of migrating cells and was subsequently found active in the extracellular matrix (ECM). Lamellipodia became anchored through primordial contacts established with type IV collagen. MMP-9 became amassed behind collagen IV where there were fewer cell–ECM contacts. Both collagen IV and MMP-9 were involved in cell migration because when cell–collagen IV interaction was blocked, cells spread slightly but did not migrate; and when MMP-9 activation was prevented, cells remained fixed on primordial contacts and did not advance at all. These observations suggest that MMP-9 controls the migration of repairing HBEC by remodeling the provisional ECM implicated in primordial contacts

Standard of hygiene and immune adaptation in newborn infants

Peer reviewe

Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child

Background &amp; aims: Maternal gluten intake in relation to child's risk of type 1 diabetes has been studied in few prospective studies considering the diet during pregnancy but none during lactation. Our aim was to study whether gluten, cereals, or dietary fiber in maternal diet during pregnancy and lactation is associated with the risk of islet autoimmunity or type 1 diabetes in the offspring. Methods: We included 4943 children with genetic susceptibility to type 1 diabetes from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study, born between 1996 and 2004. Maternal intake of gluten, different types of cereals, and dietary fiber were derived from a semi-quantitative validated food frequency questionnaire covering the eighth month of pregnancy and the third month of lactation. Children were monitored for islet autoantibodies up to age of 15 years and type 1 diabetes until year 2017. Risk of islet autoimmunity and clinical type 1 diabetes were estimated using Cox regression model, adjusted for energy intake, child's sex, HLA genotype, and familial diabetes. Results: Altogether 312 children (6.4%) developed islet autoimmunity at median age of 3.5 (IQR 1.7, 6.6) years and 178 children (3.6%) developed type 1 diabetes at median age of 7.1 (IQR 4.3, 10.6) years. Gluten intake during pregnancy was not associated with islet autoimmunity (HR 0.96; 95% CI 0.68, 1.35), per 1&nbsp;g/MJ increase in intake nor type 1 diabetes (HR 0.96; 95% CI 0.62, 1.50) in the offspring. Higher barley consumption during lactation was associated with increased risk of type 1 diabetes (HR 3.25; 95% CI 1.21, 8.70) per 1&nbsp;g/MJ increase in intake. Maternal intake of other cereals or dietary fiber was not associated with the offspring outcomes. Conclusions: We observed no association between maternal intake of gluten, most consumed cereals, or dietary fiber during pregnancy or lactation and the risk of islet autoimmunity or type 1 diabetes in children from a high-risk population

” kuus- seittemänkymppiset zumbaa…”Kemiläisten hyvinvointialan yrittäjien näkemyksiä kolmasikäläisten palvelutarpeesta nyt ja lähitulevaisuudessa

Opinnäytetyön kuvaus: Vuonna 2030 yli neljännes suomalaisista ennustetaan olevan vähintään 65 vuotta täyttäneitä. Tulevaisuuden ikääntyvät ovat aikaisempaa koulutetumpia ja oikeuksistaan tietoisempia. He osaavat ajaa omia etujaan paremmin ja ovat taloudellisesti vauraampia. Yhteiskunnassa vallitsee voimistuva mielenkiinto kolmannessa iässä oleviin kuluttajiin. Kolmasikäläiset nähdään aktiivisina ja monipuoli-sina kuluttajina, joilla on aikaa, varaa ja ennakkoluulottomuutta toimia kulutuksen eri kentillä. Tämä synnyttää kysymyksiä siitä, millaisia palveluja tämä kasvava ikääntyvien ikäryhmä haluaa ja keneltä he ovat niitä valmiita hankkimaan. Teoreettinen ja käsitteellinen esittely: Tämän opinnäytetyön tavoitteena on selvittää millaisia hyvinvointipalveluja kolmasikäläiset tarvitsevat ja toivovat yrittäjiltä nyt ja lähitulevaisuudessa. Tässä työssä kolmasikäläisillä tarkoitetaan 58- 78- vuotiaita ikääntyviä. Teoreettisessa viitekehyksessä tarkastelen hyvinvoinnin, iän ja ikäänty-misen määritelmiä, sekä hyvinvointipalveluja ja kolmasikäläisiä kuluttajina. Metodologinen esittely: Opinnäytetyöni lähestymistapa on laadullinen eli kvalitatiivinen. Tutkimusmenetelmä oli teemahaastattelu. Haastattelin neljää Kemin hyvinvointialan yrittäjää. Analysoin aineiston teemoittelulla. Keskeiset tutkimustulokset ja johtopäätökset: Tulevaisuuden ikääntyvät ovat nykyistä valmiimpia käyttämään varallisuutta omaan hyvinvointiin. Kolmasikäläisten palvelutarpeet kohdistuvat tulevaisuudessa enemmän vapaa-aikaan, harrastuksiin ja kulttuuriin. Henkilökohtaisen palvelun merkitys korostuu ja ikääntyvät haluavat yksilöllisempiä palvelukokonaisuuksia. Haastattelemani yrittäjät olivat sitä mieltä, että tulevaisuudessa ostetaan enemmän palveluja yksityisiltä hyvinvointipalvelun tuottajilta.Thesis description: In year 2030, more than quarter of Finnish is expected to be over 65 years old. In the future the elderly are more educated and more aware of their rights. They know how to run their own interests and are more economically pros-perous. Society, there is growing interest of consumers who are in their third age. People in their third age are seen as active and diverse consumers, who have time, prosperity and liberality to act different areas of consumption fields. This rise questions about the type of services this growing group of people in their third age wants and from whom they are willing to purchase them. Theoretical summary: The aim of my bachelor` s thesis is to explain what kind of welfare services people in their third age need and hope for from welfare entrepreneurs. In this thesis third age means people who are 58 - 78 years old. In theoretical context I scrutinise concepts of wellbeing, age and ageing, entrepreneurship in welfare sector and consumer behaviour in third age. Methodological summary: The study method of my bachelor` s thesis is qualitative research. Method was theme interview. I interviewed four entrepreneurs who operate in welfare sector in Kemi. I analyzed material using typecasting. Main results and conclusions: In the future, older people are more willing to spend money on their own wellbeing. In the future, service needs of people in their third age are focused in leisure time, hobbies and culture. In the future meaning of personal service is emphasized and elderly wants more individualized service packages. Entrepreneurs interviewed were of the opinion that in the future more and more services are purchased from private welfare service providers

Budjetointi strategisen talousjohtamisen päätöksenteon tukena

Opinnäytetyön tavoitteena oli budjetoinnin jatkuva kehittäminen vastaamaan paremmin kohdeyrityksen tarpeita. Tarkoituksena oli kehittää kohdeyrityksen budjetointia hyödyllisellä ja käytännönläheisellä tavalla digitalisoiden. Kehittämistehtävän lähtökohtana oli näkemys siitä, miten budjetointia tulisi kehittää niin, että se palvelisi tehokkaammin kohdeyrityksen johtoa päätöksenteossa ja tulevaisuuden suunnittelussa. Kehittämistehtävän tavoitteena oli myös selvittää, voiko budjetoinnin avulla varmistaa toiminnan linjaamista halutun strategian mukaiseksi ja huolehtia yrityksen toiminnan myönteisestä kasvusta. Kehitystehtävän tavoitteena oli myös hyödyntää budjetoinnin automatisoinnin tuoma mahdollisuus resurssisäätöihin, informaation tehokkaampaan hyödyntämiseen ja nopeampaan reagointiin muutostilanteessa. Laadullisen tutkimuksen ominaispiirteiden vuoksi kvalitatiivinen tutkimusote valittiin kehittämistyön lähestymistavaksi. Tarkemmaksi tiedonhankintamenetelmäksi valittiin liiketaloustieteissä runsaasti sovellettava tapaustutkimus, jossa perehdyttiin tutkittavan ilmiön kannalta valittuun tapaukseen. Tapaustutkimus soveltui kehittämistyön lähestymistavaksi, kun tehtävänä oli tuottaa kehittämisehdotus tai -idea budjetointityökaluksi. Budjetointityökalua kehitettiin yrityksen strategisen talousjohtamisen päätöksenteon tueksi. Tiedonkeruumenetelmänä käytettiin haastattelua. Teemahaastattelun avulla kartoitettiin ylimmän johdon ja koulutuspäälliköiden tarpeet kehitettävälle budjetointityökalulle. Haastattelukysymykset liittyivät nykytilanteeseen, budjetoinnin ja budjetointityökalun kehittämiseen sekä budjetoinnin kehittämisestä strategisen talousjohtamisen päätöksenteon tukena. Tietoperusta rakentui strategisen talousjohtamisen ja budjetoinnin teorioiden ympärille. Strategisen talousjohtamisen teoriassa tarkasteltiin taloushallinnon roolia yrityksen strategian toteuttamisessa ja sen kykyä luoda arvoa yritykselle. Budjetoinnin teoria keskittyy budjetoinnin merkitykseen taloushallinnon työkaluna ja sen rooliin päätöksenteon tukena. Strategisen talousjohtamisen avulla yritysjohto pyrkii toteuttamaan toiminta-ajatustaan, saavuttamaan päämääränsä ja kehittymään muuttuvassa toimintaympäristössä.This thesis was made for The Institute of Management and Technological Training, which is one of the leading institutes in Finland in the fields of Business Management and Leadership, Management of Technology and Organizational Development. The aim of this Master´s thesis was the continuous development of budgeting to better meet the company's needs. The purpose was to develop the target company's budgeting in a useful and practical way by digitalizing it. The starting point of the development was a vision of how budgeting should be developed so that it serves the management of the target company more efficiently in decision-making and future planning. The goal of the development was also to find out whether budgeting can be used to ensure the alignment of operations in accordance with the desired strategy and ensure the growth of the company's operations. The goal of the development task is also to achieve the potential brought by the automation of budgeting for saving resources, more efficient utilization of information and faster reaction to change. Due to the characteristics of qualitative research, a qualitative research sample was chosen as the approach for the development work. A case study, which is widely used in business economics, was chosen as a more detailed data acquisition method, in which the case chosen in terms of the phenomenon under study was familiarized. The case study was suitable as an approach to development work when the task was to produce a development proposal or idea as a budgeting tool. The budgeting tool was developed to support the company's strategic financial management decision-making. An interview was used as the data collection method. Thematic interviews were used to survey the needs of management and chief of training and education for the budgeting tool to be developed. The interview questions were related to the current situation, the future, the development of budgeting and the budgeting tool, and the development of budgeting as a support for strategic financial management decision-making. The professional knowledge base was built around the theories of strategic financial management and budgeting. In the theory of strategic financial management, the role of financial management in the implementation of the company's strategy and its ability to create value for the company were examined. The theory of budgeting focuses on the importance of budgeting as a financial management tool and its role as a support for decision-making. With the help of strategic management, company management strives to implement its operating concept, achieve its goals, and develop in a changing operating environment