New access to lipo-chitooligosaccharide nodulation factors

International audienc

New access to lipo-chitooligosaccharide nodulation factors

International audienc

Schnellerkennungsmethoden fuer die Eingangskontrolle bei Abfallbeseitigungsanlagen

With 18 refs., 8 tabs., 2 figs.TIB: RN 8908(89-106) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Gutachten zur Verbesserung des Absatzes von Wertstoffen aus Abfaellen

Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Realisation of small molecule libraries based on frameworks distantly related to natural products

The availability of high-quality screening compounds is of paramount importance for the discovery of innovative new medicines. Natural product (NP) frameworks can inspire the design of productive compound libraries. Here, we describe the design and synthesis of four compound libraries based on scaffolds that have broad NP-like features, but that are only distantly related to specific NPs. The optimisation of syntheses of the scaffolds using [5 + 2] cycloaddition chemistry is detailed, together with methods to yield exemplar decorated screening compounds. In each case, a library was nominated for production, leading to a total of >2900 screening compounds that augmented the Joint European Compound Library of the European Lead Factory