Intracluster electron transfer from a metal atom/cluster followed by anionic oligomerization of vinyl molecules

科研費報告書収録論文(課題番号:13640498・基盤研究(C)(2) ・H13～H14/研究代表者:美齊津, 文典/アニオン重合初期反応系モデルとしての金属-分子クラスターの幾何・電子構造の研究

Electron distribution and intracluster reaction in [Nan(CS2)2]? negative ion clusters

科研費報告書収録論文(課題番号:15350003・基盤研究(B)(2)・15～16/研究代表者:美齊津, 文典/イオンドリフトチューブ法による異性体分離分光のクラスター内反応生物への適用

Studies on Solvation Structure and Intracluster Reaction of Aqueous Metal Ions by IR Photodissociation Spectroscopy

セミナー開催, 2005年7月22日, Buntine Group, at The University of Adelaide, in Adelaide, Australi

Distributional and reproductive aspects of the bigeye thresher shark (Alopias superciliosus) in the Atlantic ocean

Captura asociada a la pesquería de palangre de superficie dirigida a pez espadaThe bigeye thresher shark, Alopias supercilious is sometimes caught as bycatch in pelagic longline fisheries targeting tunas and swordfish in the Atlantic Ocean. As part of an ongoing cooperative program for fisheries and biological data collection, fishery observer data from various fishing nations and projects were compiled and analyzed. Those data sets include information on geographic location of the observations, as well as size, sex and in some cases maturity stage. A total of 4371 bigeye threshers were recorded throughout the Atlantic Ocean between 1992 and 2013, with the sizes ranging from 70 to 305 cm FL (fork length). Considerable variability was observed in the catchat- size, with particular emphasis on the tropical region where the mean sizes tended to be smaller than in the other regions. The expected distribution of juvenile and adult specimens also showed considerable variability, and the sex-ratios varied between regions and size classes. Maturity ogives were fitted to data from 642 specimens, with the median sizes at maturity estimated at 208.6 cm FL (corresponding to 349.1 cm TL) for females and 159.2 cm FL (corresponding to 269.8 cm TL) for males. In addition, a segmented regression model (SRM) was used for males, and two breakpoints (Bk1: 122.5cm FL, Bk2: 173.3cm FL) estimated, identifying transitions between the three different maturity stages for male sharks (immature, maturing and mature). Only a few pregnant females were recorded, always with the presence of two embryos (one per uterus), and were distributed predominantly in the tropical northeast Atlantic closer the African continent, and in the southwest region, with those regions possibly serving as nursery areas for this species. These reproductive parameters, and especially the estimated median sizes at maturity and low fecundity, highlight the vulnerability of this species, reinforcing that the bigeye thresher tends to mature at a larger size than the other species of the Alopiidae family. The biological and distributional patterns presented can help managers adopt more informed and efficient conservation measures for this species.En prensa0,000

Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome:A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study

OBJECTIVES: Interventional trials aimed at pediatric acute respiratory distress syndrome prevention require accurate identification of high-risk patients. In this study, we aimed to characterize the frequency and outcomes of children meeting "at risk for pediatric acute respiratory distress syndrome" criteria as defined by the Pediatric Acute Lung Injury Consensus Conference. DESIGN: Planned substudy of the prospective multicenter, international Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study conducted during 10 nonconsecutive weeks (May 2016-June 2017). SETTING: Thirty-seven international PICUs. PATIENTS: Three-hundred ten critically ill children meeting Pediatric Acute Lung Injury Consensus Conference "at-risk for pediatric acute respiratory distress syndrome" criteria. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We evaluated the frequency of children at risk for pediatric acute respiratory distress syndrome and rate of subsequent pediatric acute respiratory distress syndrome diagnosis and used multivariable logistic regression to identify factors associated with subsequent pediatric acute respiratory distress syndrome. Frequency of at risk for pediatric acute respiratory distress syndrome was 3.8% (95% CI, 3.4-5.2%) among the 8,122 critically ill children who were screened and 5.8% (95% CI, 5.2-6.4%) among the 5,334 screened children on positive pressure ventilation or high-flow oxygen. Among the 310 at-risk children, median age was 2.1 years (interquartile range, 0.5-7.3 yr). Sixty-six children (21.3%) were subsequently diagnosed with pediatric acute respiratory distress syndrome, a median of 22.6 hours (interquartile range, 9.8-41.0 hr) later. Subsequent pediatric acute respiratory distress syndrome was associated with increased mortality (21.2% vs 3.3%; p < 0.001) and longer durations of invasive ventilation and PICU care. Subsequent pediatric acute respiratory distress syndrome rate did not differ by respiratory support modality at the time of meeting at risk criteria but was independently associated with lower initial saturation:FIO2 ratio, progressive tachycardia, and early diuretic administration. CONCLUSIONS: The Pediatric Acute Lung Injury Consensus Conference "at-risk for pediatric acute respiratory distress syndrome" criteria identify critically ill children at high risk of pediatric acute respiratory distress syndrome and poor outcomes. Interventional trials aimed at pediatric acute respiratory distress syndrome prevention should target patients early in their illness course and include patients on high-flow oxygen and positive pressure ventilation

2019 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations : summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research

Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease

<p>Abstract</p> <p>Background</p> <p>A high incidence of interstitial lung disease (ILD) has been reported in patients with advanced non-small cell lung cancer (NSCLC) treated with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), particularly in Japanese populations. A previous report from our laboratory demonstrated that KL-6 was a useful serum biomarker to assess the severity of drug-induced pneumonitis. Based on these observations, this study was conducted to evaluate the risk factors of EGFR-TKIs induced ILD and the usefulness of monitoring serum KL-6 levels in patients who developed EGFR-TKIs induced ILD in a large multi-institutional setting.</p> <p>Methods</p> <p>We retrospectively reviewed clinical records and radiographies of 341 patients with advanced NSCLCs who were treated with EGFR-TKIs, and analyzed risk factors for the development of EGFR-TKIs induced ILD. Changes of circulating levels of KL-6 were also evaluated in the patients who developed EGFR-TKIs induced ILD.</p> <p>Results</p> <p>Among the 341 patients included in this study, 20 (5.9%) developed EGFR-TKIs induced ILD, and 9 (2.6%) died from ILD. Univariate analyses revealed that only preexisting pulmonary fibrosis was a significant risk factor for the development of EGFR-TKIs induced ILD (<it>p </it>= 0.003). Absolute levels of circulating KL-6 at neither baseline nor the onset of ILD could discriminate between life-threatening and non-life threatening EGFR-TKIs induced ILDs. However, we found that the ratios of serum KL-6 levels just after the onset of EGFR-TKIs induced ILD to those at baseline could quite precisely distinguish survivors from non-survivors (<it>p </it>= 0.006) as well as acute interstitial pneumonia (AIP) pattern from non-AIP pattern (<it>p </it>= 0.005).</p> <p>Conclusions</p> <p>The results of this study strongly support the potential of KL-6 as a diagnostic biomarker for life-threatening EGFR-TKIs induced ILD. Monitoring of KL-6 is also useful to evaluate the progression and severity of EGFR-TKIs induced ILD.</p

Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation. Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths in the delivery of pediatric basic life support, the initial timing and dose intervals for epinephrine administration during resuscitation, and the targets for oxygen and carbon dioxide levels in pediatric patients after return of spontaneous circulation. The most controversial topics included the initial timing and dose intervals of epinephrine administration (new treatment recommendations were made) and the administration of fluid for infants and children with septic shock (this latter topic was evaluated by evidence update). All evidence reviews identified the paucity of pediatric data and the need for more research involving resuscitation of infants and children