2 research outputs found
Data from: Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study
Objectives: Obesity is a risk factor for type 2 diabetes mellitus. Among obesity, visceral fat obesity, and ectopic fat obesity, it has been unclear which has the greatest effect on incident diabetes.
Methods: In this historical cohort study of 8430 men and 7034 women, we investigated the effect of obesity phenotypes on incident diabetes. Obesity, visceral fat obesity, and ectopic fat obesity were defined as body mass index β₯25βkg/m2, waist circumference β₯90βcm in men or β₯80βcm in women, and having fatty liver diagnosed by abdominal ultrasonography, respectively. We divided the participants into eight groups according to the presence or absence of the three obesity phenotypes.
Results: During the median 5.8 years follow-up for men and 5.1 years follow-up for women, 286 men and 87 women developed diabetes. Compared to the non-obese group, the hazard ratios (HRs) of incident diabetes in the only-obesity, only-visceral fat obesity, only-ectopic fat obesity groups, and with all-three types of obesity group were 1.85 (95%CI 1.06β3.26, pβ=β0.05) in men and 1.79 (0.24β13.21, pβ=β0.60) in women, 3.41 (2.51β4.64, pβ<β0.001) in men and 2.30 (0.87β6.05, pβ=β0.12) in women, 4.74 (1.91β11.70, pβ<β0.001) in men and 13.99 (7.23β27.09, pβ<β0.001) in women and 10.5 (8.02β13.8, pβ<β0.001) in men and 30.0 (18.0β50.0, pβ<β0.001) in women. Moreover, the risk of incident diabetes of the groups with ectopic fat obesity were almost higher than that of the four groups without ectopic fat obesity.
Conclusion: Ectopic fat obesity presented the greatest risk of incident type 2 diabetes