Green Tea Consumption and Stomach Cancer Risk: A Meta-Analysis

OBJECTIVES: Green tea has been suggested to have a chemopreventive effect against various cancers including stomach cancer. The aim of this study is to elucidate the relationship between green tea consumption and stomach cancer risk by meta-analysis. METHODS: Eighteen observational studies were identified using MEDLINE, THE COCHRANE LIBRARY, RISS, and a manual search. Summary relative risks/odds ratios (RR/ORs) for the highest versus non/lowest green tea consumption levels were calculated on the basis of fixed and random effect models. Subgroup analyses were used to examine heterogeneity across the studies. RESULTS: The combined results indicate a reduced risk of stomach cancer with intake of green tea (RR/OR=0.86, 95% CI=0.74-1.00). Subgroup analysis with six studies that reported differences between the highest and lowest consumption levels equal to or greater than five cups/day revealed a statistically significant protective effect (RR/OR=0.68, 95% CI=0.53-0.87). CONCLUSION: Green tea appears to play a protective role against the development of stomach cancer. The results also suggest that a higher level of green tea consumption might be needed for a clear preventive effect to appear. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.ope

The Association between Disturbed Eating Behavior and Socioeconomic Status: The Online Korean Adolescent Panel Survey (OnKAPS)

Background: A limited amount of research, primarily conducted in Western countries, has suggested that higher socioeconomic status (SES) is associated with higher risk of eating disorders (EDs). However, little is known about this association in Asian countries. We examined the association of SES with disturbed eating behavior (DEB) and related factors in Korean adolescents. Subjects A nationwide online panel survey was conducted in a sample of adolescents (n = 6,943, 49.9% girls). DEB was measured with the 26-item Eating Attitudes Test (EAT-26). Participants who scored ≥20 on the EAT-26 were considered to have DEB. Participants’ SES was determined based on self-reported household economic status. Results: The prevalence of DEB was 12.7%: 10.5% among boys and 14.8% among girls. Both boys and girls with DEB were more likely to perceive themselves as obese, experience higher levels of stress, and have lower academic achievement. The risk for DEB was significantly higher in boys of higher SES than in those of middle SES (OR = 1.45, 95%CI = 1.05–1.99 for high SES; OR = 5.16, 95%CI: 3.50–7.61 for highest SES). Among girls, higher risk of DEB was associated with the highest and lowest SES (OR = 1.52, 95%CI: 1.13–2.06 for lowest SES; OR = 2.22, 95%CI: 1.34–3.68 for highest SES). Conclusions: Despite the lower prevalence of obesity in Korea compared with Western countries, the prevalence of DEB in Korean adolescents was high, especially among girls. Moreover, the association between SES and DEB followed a U-shaped curve for girls and a J-shaped curve for boys

Ductographic Findings of Breast Cancer

Ductography has become the gold standard for the evaluation of patients exhibiting pathologic nipple discharges. In nine patients (age range, 29-67 years; median age, 51 years) with invasive (n=5) or intraductal (n=4) cancer, ductographic findings were recorded, then correlated with mammographic and sonographic findings. Common ductographic findings included complete ductal obstruction, multiple irregular filling defects in the nondilated peripheral ducts, ductal wall irregularities, periductal contrast extravasation, and ductal displacement. Faint microcalcifications or ill-defined masses, which were not opacified by contrast material, were often discovered adjacent to ductal abnormalities. Mammographically and sonographically occult diffusely spreading intraductal cancers often manifested as pathologic nipple discharge. In such cases, meticulous ductographic examinations and interpretations were crucial in order not to miss breast cancers

Lateral resistance of mass timber shear wall connected by withdrawal-type connectors

In this study, the lateral resistances of mass timber shear walls were investigated for seismic design. The lateral resistances were predicted by kinematic models with mechanical properties of connectors, and compared with experimental data. Four out of 7 shear wall specimens consisted of a single Ply-lam panel and withdrawal-type connectors. Three out of 7 shear wall specimens consisted of two panels made by dividing a single panel in half. The divided panels were connected by 2 or 4 connectors like a single panel before being divided. The applied vertical load was 0, 24, or 120 kN, and the number of connectors for connecting the Ply-lam wall-to-floor was 2 or 4. As a result, the tested data were 6.3 to 52.7% higher than the predicted value by kinematic models, and it means that the lateral resistance can be designed by the behavior of the connector, and the prediction will be safe. The effects of wall-to-wall connectors, wall-to-floor connectors and vertical loads on the shear wall were analyzed with the experimental data.This project was funded by the Korea Forest Service (Korea Forestry Promotion Institute) and the Ministry of Land, Infrastructure and Transport (the Korea Agency for Infrastructure Technology Advancement)

Sensitivity of censored data analysis to determine the characteristic value of structural timber

In structural timber tests, unintended failure mechanisms occur frequently in specimens and their results are called censored data. There are two censored data analysis: censored maximum likelihood estimation (CMLE) and Kaplan–Meier (KM) method. In this study, the precision of the censored data analysis was investigated to determine the characteristic value, 5th percentile value, of the structural timber. The results show that (1) the 5th percentile value was underestimated by ordinary data analysis methods; maximum likelihood estimation (MLE) and Order statistics. (2) CMLE with 30% lower tail censored data and KM method provided much more precise 5th percentile value. (3) The amount of under-measurement (5 MPa, 10 MPa, and 15 MPa in this simulation study) did not show significant effect on the 5th percentile determination in CMLE and KM method, but the proportion of censored data (percentage of unintended failure specimen; 10%, 20%, 30%, and 40%) affected the determination of 5th percentile value. (4) CMLE with 30% lower tail censored data and KM method showed good agreement in case that the data included unintended failure data up to 20%.(1) This work was supported by Research Resettlement Fund for the new fac‑ulty of Seoul National University. (2) This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2017R1A2B1010748)

Prediction of withdrawal resistance for a screw in hybrid cross-laminated timber

The aim of this study was to predict the withdrawal resistance of a screw in hybrid cross-laminated timber (CLT) composed of two types of lamina layers. A theoretical model to predict the withdrawal resistance was developed from the shear mechanism between a screw and the layers in hybrid CLT. The parameters for the developed model were the withdrawal stiffness and strength that occurs when a screw is withdrawn, and the penetration depth of a screw in layers of a wood material. The prediction model was validated with an experimental test. Screws with two different diameters and lengths (Ø6.5 × 65mm and Ø8.0 × 100mm) were inserted in a panel composed of solid wood and plywood layers, and the withdrawal resistances of the screws were evaluated. At least 30 specimens for each group were tested to derive the lower 5th percentile values. As a result, the developed model predictions were 86–88% of the lower 5th percentile values of hybrid CLT from the properties of the lamina layer. This shows that the withdrawal resistance of hybrid CLT can be designed from the properties of its layer.This project was funded by the Korea Forest Service (Korea Forestry Promotion Institute) and the Ministry of Land, Infrastructure and Transport (the Korea Agency for Infrastructure Technology Advancement)

Red Ginseng Extract Facilitates the Early Differentiation of Human Embryonic Stem Cells into Mesendoderm Lineage

Human embryonic stem cells (hESCs) have capacities to self-renew and differentiate into all cell types in vitro. Red ginseng (RG) is known to have a wide range of pharmacological effects in vivo; however, the reports on its effects on hESCs are few. In this paper, we tried to demonstrate the effects of RG on the proliferation and differentiation of hESCs. Undifferentiated hESCs, embryoid bodies (EBs), and hESC-derived cardiac progenitors (CPs) were treated with RG extract at 0.125, 0.25, and 0.5 mg/mL. After treatment of undifferentiated hESCs from day 2 to day 6 of culture, BrdU labeling showed that RG treatment increased the proliferation of hESCs, and the expression of Oct4 and Nanog was increased in RG-treated group. To find out the effects of RG on early differentiation stage cells, EBs were treated with RG extract for 10 days and attached for further differentiation. Immunostaining for three germ layer markers showed that RG treatment increased the expressions of Brachyury and HNF3β on EBs. Also, RG treatment increased the expression of Brachyury in early-stage and of Nkx2.5 in late-stage hESC-derived CPs. These results demonstrate facilitating effects of RG extract on the proliferation and early differentiation of hESC