Anti-Phospholipid Syndrome In Nigeria: Report Of Five Cases

Five cases of secondary anti-phospholipid syndrome (APS) are presented andliterature reviewed. Pregnancy loss was the most common presentation but neurologic manifestations are also seen. IgG ACA was more commonly seen than IgM ACA. Although APS has been infrequently reported in black Africans, an awareness of this condition is needed especially among females with previous recurrent pregnancy losses

Elucidation of Bioactive Compounds in Methanol Extract of Mitracarpus Vilosus Leaf using GC-MS analysis

Mitracarpus vilosus is widely used among the indegenes of Ibeju-Lekki area of Lagos State for the treatment of skin lesions. This study elucidated the phytochemical constituents in 80% methanolic leaf extract of Mitracarpus vilosus. Phytochemical screening and gas chromatography-mass spectrometry (GC-MS) analyses were carried out on the leaf extract. The qualitative analyses showed the presence of the following phytochemicals, tannins, terpenoids, saponins, cardiac glycosides and steroids. The phytochemical screen did not reveal any flavonoids. However, Squalene 14.27%, n-Hexadecanoic acid 11.60%, 2-Octylcyclopropene-1-heptanol 8.43%, Octadecanoic acid 5.45%, 1,4-Naphthalenedione 3.19% were the first five major bioactive compounds revealed by GC-MS in the leaf extract. The results of this study validated the bioactive constituents in Mitracarpus vilosus which may be the justification for its use for the treatment of skin lesions and other ailments. DOI: 10.7176/JBAH/12-14-04 Publication date:July 31st 202

Elucidation of Phytochemicals in Mitracarpus Vilosus Flower Extract using GC-MS

Mitracarpus villosus which belongs to the family of Rubiaceae is one of the important medicinal plants widely known for its broad spectrum of pharmacological activities and biological uses which includes antioxidant, antimicrobial, anti-inflammatory, anti-cancer, anti-ulcer, and antibacterial activities amongst others. It is used in the treatment of various ailments such as ulcers, and skin-related infections like dermatitis, eczema, psoriasis, and acne. This study elucidated the phytochemical properties of Mitracarpus villosus flower. This was achieved through the methanolic extraction of M. villosus flower, and further phytochemical analysis of the methanol extract such as the tannins, saponins, flavonoids, steroids, terpenoids, and cardiac glucoside contents. Moreso, the use of Gas Chromatography-Mass Spectrophotometry (GC-MS) technique was employed on the methanolic extract to isolate and characterize the different bioactive compounds present and to further validate the qualitative data obtained from the phytochemical analysis. Results obtained exhibited the presence of tannins, saponins, flavonoids, steroids, and cardiac glucoside, with a noticeable absence of terpenoids. Also, the GC-MS analysis showed spectra of 52 bioactive compounds present in the extract with five specific compounds having the highest composition such as oleic acid (14.76%), 9,12-Octadecadienoic acid (11.25%), n-Hexadecanoic acid (10.92%), octadecanoic acid (9.21%), and squalene (8.87%) having the highest composition. The presence of these phytochemicals with their numerous biological activities in the methanolic extract of M. vilosus flower makes it a promising pharmaco-therapeutic agent, and thus should be employed in medicine for the treatment of diseases and also as an active agent in the pharmaceutical and non-pharmaceutical industries. Keywords: Mitracarpus vilosus flower, Phytochemicals, Methanol extracts, GC-MS DOI: 10.7176/JBAH/12-14-05 Publication date:July 31st 202

EFFECTS OF ASCORBIC ACID SUPPLEMENTATION ON THE PERFORMANCE INDICES OF STARTER PULLETS IN A HOT - HUMID ENVIRONMENT

Two studies were conducted to evaluate the nutritional effects of supplementary ascorbic acid (AA) at levels of 0, 100, 200, and 300 mg/kg in the diets of starter pullets reared at different seasons (harmattan season and rainy season) in a hot humid environment. Two hundred and forty day-old Harco pullet chicks were used in each trial, they were randomly assigned to each of the four dietary treatments in three replications of twenty chicks per replicate. Each trial lasted 8 weeks during which data were collected and a 2 X 4 factorial arrangement was employed in the analysis of data collected.  Results showed significant (p<0.05) effect of treatments on feed conversion ratio of birds fed dietary treatments. Season of presentation of ascorbic acid significantly affected (p<0.05) feed intake with higher value obtained in the rainy season compared to the dry season (41.89g vs. 39.59). &nbsp

CONSUMPTION PATTERN OF MAIZE BASED DISHES IN FOUR AGRO-ECOLOGICAL ZONES OF NIGERIA

The global picture had dramatically changed the lifestyles of Nigerian citizens pushing them into various fast-eating cultures with more instant and tasty meals, and the attendant gradual relegation of our traditional rich eating cultures. Studies were carried in eight Local Government Areas of Nigeria from the four Agro-Ecological Zones (AEZs) namely: moist savanna (Oyo State), humid forest (Lagos State), mid-altitude (Abuja) and dry Savanna (Kaduna State). Stratified multistage sampling technique with structured questionnaires from 1641 respondents and focus group discussions (FGDs) were employed to identify the maize-based dishes consumed and determined the frequency of consumption. The demographic characteristics revealed that 54.8% of the respondents were male. Residents in the rural area were more (56.8%) and majority of the respondents were between the ages of 26-45 years (67.6%), while more Christians (57.88%) participated in the study than any other religion. Results showed that thirty–two maize-based dishes were identified, of which ten were frequently consumed. Ogi was the most popular maize-based dish (73.5%) consumed in the AEZs while corn pudding was the least consumed (28.5%). There were significant differences (p<0.05) in all the sensory attributes measured. The low consumption of majority of the maize-based dishes raises concern for the current campaign on mobilizing local biodiversity which has been reported to be one of the food based intervention strategies for solving nutrition problems among population groups

Could a simple antenatal package combining micronutritional supplementation with presumptive treatment of infection prevent maternal deaths in sub-Saharan Africa?

BACKGROUND: Reducing maternal mortality is a key goal of international development. Our objective was to determine the potential impact on maternal mortality across sub-Saharan Africa of a combination of dietary supplementation and presumptive treatment of infection during pregnancy. Our aim was to demonstrate the importance of antenatal interventions in the fight against maternal mortality, and to stimulate debate about the design of an effective antenatal care package which could be delivered at the lowest level of the antenatal health system or at community level. METHODS: We collated evidence for the effectiveness of antenatal interventions from systematic reviews and controlled trials, and we selected interventions which have demonstrated potential to prevent maternal deaths. We used a model-based analysis to estimate the total reduction in maternal mortality in sub-Saharan Africa which could be achieved by combining these interventions into a single package, based on a WHO systematic review of causes of maternal deaths. RESULTS: Severe hypertensive disorders, puerperal sepsis and anemia are causes of maternal deaths which could be prevented to some extent by prophylactic measures during pregnancy. A package of pills comprising calcium and iron supplements and appropriate anti-microbial and anti-malarial drugs could reduce maternal mortality in sub-Saharan Africa by 8% (range <1% to 20%). This estimate is based on Cochrane Review estimates for the effectiveness of daily calcium supplements in reducing the risk of death/serious morbidity due to hypertensive disorders (RR = 0.80, 95% CI 0.65-0.97), anti-microbial prophylaxis in reducing the odds of puerperal sepsis/postpartum endometritis (OR = 0.49, 95% CI 0.23-1.06), anti-malarial prophylaxis in reducing the risk of severe antenatal anemia (RR = 0.62, 95% CI 0.50-0.78), and iron supplementation in reducing the risk of iron deficiency anemia at term (RR = 0.33, 95% CI 0.16-0.69). CONCLUSION: Maternal mortality could be reduced by a combination of micronutrient supplementation and presumptive treatment of infection during pregnancy. Such an approach could be adopted in resource-poor settings where visits to antenatal clinics are infrequent and would complement existing Safe Motherhood activities

Systemic onset juveniile chronic arthritis (JCA) in a Nigerian boy: a case report

Background: Juvenile chronic arthritis (JCA) is a chronic arthritis affecting children below age of 16 years. The systemic onset subgroup is also known as Still's disease. There are several distinct subgroups. There is paucity of literature of this disease entity in our environment due to under diagnosis of the disease. Method: The case note of this patient was retrieved. He was managed for 2 years in the adult rheumatology clinic after being transferred from the Paediatric unit. Relevant literature was reviewed. Result: There was a good response to immunosuppressive agents and low dose prednisolone. He was back at School and able to play with his mates after long withdrawal from School. Conclusion: Prompt referral of such cases to specialist centers will go a long way in determining the outcome of such patients. Prognosis is better with early presentation and appropriate management. Nigerian Journal of Medicine Vol. 17 (1) 2008 pp. 112-11

Ocular Manifestations of Autoimmune Diseases — Review of literature

No Abstract. Nigerian Journal of Ophthalmology Vol. 14 (2) 2006: pp. 68-7