Bite-to-hospital time and morbidity in victims of viper bite in a rural hospital in Nigeria

Background: Mortality amongst in-hospital patients bitten by carpet viper in northern Nigeria has reduced, related to use of a monospecific ovine Fab snake antivenom. However, many victims survive with temporary or permanent morbidity.Objectives: Study objectives were to: (1) determine and score the morbidity caused by carpet viper bite; and (2) find the relationship between bite-to-hospital time and morbidity amongst victims of carpet viper bite.Method: A prospective study was conducted in a rural hospital in north-central Nigeria. The morbidities scored were oedema, tenderness, prolonged whole-blood clotting time, blister, ulcer, need for blood transfusion, coma, hypotension, convulsion, length of hospital stay, need for disarticulation, and need for skin graft. A score of one was given to each objective sign. The bite-to-hospital time of 233 subjects was obtained. Descriptive and inferential statistical analysis was done.Results: Most of the subjects (150 or 64%) came to the hospital within 6 hours of the snake bite, with 2 (1%) arriving within 1 hour. The median bite-to-hospital time was 5 hours, with a range of 0.5–216 hours. Major morbidities were oedema, seen in 212 (91.0%; 95% CI 86.6–94.3%); incoagulable blood, seen in 205 (88%; 95% CI 83.1–91.9%), and tenderness, seen in 201 (86.3%; 95% CI 81.2–90.4%). The mean morbidity score was 8 ± 4. For every unit increase in logged bite-to-hospital time, the morbidity score increased by 1.85 (p < 0.001).Conclusion: Morbidity caused by carpet viper bite is high in Zamko, north-central Nigeria, and correlates with increasing bite-to-hospital time

Essential and Non-Essential Metals Profile in Blood of some Nigerian Pregnant Women

In this study, the concentrations of some essential (Ca, Cu, Fe, Mg, Mn, Ni, and Zn) and non-essential metals (Cd and Pb) were determined in blood of pregnant women aged between 15 – 45 years and enrolled at the Obafemi Awolowo University Teaching Hospitals Complex, Ile – Ife, Nigeria, for antenatal care. Fifty samples of whole blood were collected from the pregnant women and twenty five samples from non pregnant women as control. Levels of essential and non- essential metals were determined by atomic absorption spectrophotometry. The analyses were performed in order to assess the body burden of pregnant women with the metals and the health implications of the latter to pregnant women and their fetuses. Data analysis by descriptive and inferential statistics revealed that age, education, and profession correlate with the levels of the metals. The mean levels of the two non-essential metals obtained in this study were lower than the recommended limits for whole blood. While compared with other studies of pregnant women elsewhere results obtain were generally higher. Generally the values obtained in this study have indicated no serious body burden on the pregnant women. The importance of establishing factors that influence low human exposure concentrations is becoming critical in efforts to reduce exposures and hence the potential for adverse health effects. ©JASE

Seasonal variations in heavy metal concentrations in soil and some selected crops at a landfill in Nigeria

In this study, the seasonal variations in concentrations of the heavy metals - As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn - in soil and crops from a farm near the refuse dump site of Obafemi Awolowo University, Ile-Ife, Nigeria were investigated during the two major seasons of Nigeria. This was done to assess the pollution status of the farm and hence the safety levels of the crops produced. Soil and crop samples collected during the 2005/2006 rainy and dry seasons were treated and digested using standard wet digestion methods. Heavy metals were determined with Atomic Absorption Spectrophotometer (AAS). Analytical results of soil from landfill indicated that in the wet and dry seasons, values for Cd, Cu, Fe, Ni, Cr, Zn, Co and Pb were higher than normal levels of a typical agricultural soil, but As (3.20 and 4.13 mg/kg) was found to be within the acceptable range while Mn values of 597.00 - 828.37 mgkg-1 were slightly above the usual background levels. The study showed highest concentrations of As (8.31 mg/kg), Cr (9.00 mg/kg) and Ni (40.00 mg/kg) in Manihot esculenta leaves; Cu (25.0 0 mg/kg) and Fe (176.00 mg/kg) in Xantosoma mafaffa tuber; Cd (14.50 mg/kg), Co (22.50 mg/kg), Mn (189.50 mg/kg), Pb (680.00 mg/kg) and Zn (440.59 mg/kg) in Talinum triangulare. In general, the levels of heavy metals in soil and crops were higher in the dry season than in the wet season, but this difference is not statistically significant. Particularly, the levels of As, Cd, Cr, Ni, and Pb were above the critical toxic level in plant leaves in both dry and wet seasons while Zn and Cu occurred at toxic levels only in the dry season.Key words: Contamination, heavy metals, landfill, refuse dump, transfer factor

Biomass, Abundant Resources for Synthesis of Mesoporous Silica Material

The synthesis of mesoporous silica materials was reviewed with a view to discuss the reaction mechanism and the various attempts made at enhancing the materials’ properties by utilizing varieties of templating agents and silica frameworks from pure synthetic chemicals. This chapter also reviewed studies in which either the template or the framework was synthesized from benign reagents obtained from renewable sources, to achieve enhanced material properties. The view was to encourage the development of mesoporous silica materials in which both the template and the silica framework are from biomass origin. This approach may promote the large‐scales synthesis of mesoporous silica for commercial purposes, which had previously been hampered by the toxic nature, cost of synthetic chemical reagents, and unsustainable synthetic routes

Agama lizard: A potential biomarker of environmental heavy metal pollution assessment

In this study, the suitability of Agama lizard as a biomarker in assessing environmental pollution levels of arsenium (As), barium (Ba), cadmium (Cd), copper (Cu), manganese (Mn), lead (Pb) and zinc (Zn) was investigated. Samples of top soil and agama lizards were taken from five sites within a university community in Nigeria for the study. Soil samples, livers and kidneys from the lizards were subjected to wet acid digestion and levels of heavy metals in the digested samples were determined using an atomic absorption spectrophotometer (AAS). Results of the study showed that the levels of the metals ranged from Cd, 20.4 ± 2.6 ìg/g to Zn, 978.6 ± 2.2 ìg/g in soil; Cd, not detected to Zn, 42.2 ± 0.3 ìg/g in liver; As and Ba, not detected to 47.6 ± 1.0 ìg/g Zn in kidney. The inter matrices correlation coefficient values obtained for the heavy metals showed that the kidney of lizards would be more relevant in assessing soil levels of such heavy metals as As, Ba, Cd, Mn and Pb among others.Key words: Agama lizard, environmental pollution, soil, heavy metals, liver, kidney

Essential and Non-Essential Metals Profile in Blood of some Nigerian Pregnant Women

In this study, the concentrations of some essential (Ca, Cu, Fe, Mg, Mn, Ni, and Zn) and non-essential metals (Cd and Pb) were determined in blood of pregnant women aged between 15 \u2013 45 years and enrolled at the Obafemi Awolowo University Teaching Hospitals Complex, Ile \u2013 Ife, Nigeria, for antenatal care. Fifty samples of whole blood were collected from the pregnant women and twenty five samples from non pregnant women as control. Levels of essential and non- essential metals were determined by atomic absorption spectrophotometry. The analyses were performed in order to assess the body burden of pregnant women with the metals and the health implications of the latter to pregnant women and their fetuses. Data analysis by descriptive and inferential statistics revealed that age, education, and profession correlate with the levels of the metals. The mean levels of the two non-essential metals obtained in this study were lower than the recommended limits for whole blood. While compared with other studies of pregnant women elsewhere results obtain were generally higher. Generally the values obtained in this study have indicated no serious body burden on the pregnant women. The importance of establishing factors that influence low human exposure concentrations is becoming critical in efforts to reduce exposures and hence the potential for adverse health effects

Cardiovascular risk factors in adult general out-patient clinics in Nigeria: a country analysis of the Africa and Middle East Cardiovascular Epidemiological (ACE) study.

Background: With globalization and rapid urbanization, demographic and epidemiologic transitions have become important determinants for the emergence of cardiovascular disease (CVD).Objective: To estimate the prevalence of CVD risk factors in adult out-patients attending general practice and non-specialist clinics in urban and rural Nigeria.Methods: As part of the Africa and Middle East Cardiovascular Epidemiological (ACE) study, a cross-sectional epidemiologic study was undertaken for the presence of hypertension, diabetes mellitus, dyslipidemia, obesity, smoking and abdominal obesity in Nigeria.Results: In total, 303 subjects from 8 out-patient general practice clinics were studied, 184 (60.7%) were female and 119 (39.3%) were male. Mean age was 42.7±13.1 years; 51.8% were aged &lt;45 years; 4% ≥65 years. Over 90% of subjects had ≥1 of 6 selected modifiable cardiovascular risk factors: 138 (45.6%) had 1-2; 65 (21.5%) had 3; 60 (19.8%) had 4; and 11 (3.6%) had 5 concurrent risk factors. Screening identified 206 subjects (68.0%) with dyslipidemia who did not have a prior diagnosis.Conclusion: Cardiovascular risk factors are highly prevalent in Nigerian subjects attending out-patient clinics. Moreover, many subjects were undiagnosed and therefore unaware of their cardiovascular risk status. Opportunistic screening alongside intensive national, multisectoral education or risk factor education is needed, should be scaled up nationwide and rolled out in both urban and rural communities in Nigeria.Keywords: Nigeria, cardiovascular risk factors, screening programs, risk factor management, The Africa and Middle East Cardiovascular Epidemiological (ACE) study

Speciation Study of Heavy Metals in Soil within the Vicinity of a Metal Recycling Factory at Ile-Ife, Southwestern Nigeria

A speciation study of Al, Cd, Cu, Mn, Pb and Zn in soil samples from a metal recycling factory in Ile-Ife Osun State, Nigeria, was carried out in order to assess the heavy metal pollution impact of the industrial processes on the immediate environment. Surface soil dust samples collected within the vicinity of the factory were subjected to a five-stage sequential extraction process. Levels of heavy metals in each fraction were determined using Flame Atomic Absorption Spectrophotometer (FAAS). The overall mean values obtained for the metals in the fractions gave the range: Al (0.03 ± 0.01 to 0.20 ± 0.01 µg/g ); Cd (0.03 ± 0.01 to 0.23 ± 0.02 µg/g) ; Cu (2.93 ± 0.02 to 18.30 ± 1.95 µg/g) ; Mn (17.33 ± 0.03 to 91.68 ± 2.90 µg/g); Pb (0.03 ± 0.01 to 0.43 ± 0.02 µg/g)  and Zn (8.20 ± 0.01 to 35.08 ± 0.02 µg/g) . Both the contamination index and enrichment factor results indicated that all the soil samples were contaminated with Cd while a few sites showed Cu contamination. The mobility potential of the metals in the soil sample decreased in the order: Mn &gt; Al &gt; Zn &gt; Cd &gt; Cu &gt; Pb (West) and Cd &gt; Al &gt; Pb &gt; Zn &gt; Mn &gt; Cu (East). The study revealed that the soil around the metal recycling factory is contaminated with heavy metals, and if left unmonitored and controlled could lead to serious environmental risk in the future.Â

Evidence suggesting that di-n-butyl phthalate has anti-androgenic effects in fish

This article is the pre-print version of the full and final published article.Phthalate ester plasticizers are anti-androgenic in mammals. High doses of certain phthalates consistently interfere with the normal development of male offspring exposed in utero, causing disrupted sperm production, abnormal development of the genitalia, and in some cases infertility. In the environment, phthalates are considered ubiquitous and are commonly measured in aquatic ecosystems at low ng to mu g per litre concentrations. Given the similarity between mammalian and teleost endocrine systems, phthalate esters may be able to cause anti-androgenic endocrine disruption in fish in the wild. In the present study, adult male three-spined sticklebacks (Gasterosteus aculetaus) (n = 8) were exposed to di-n-butyl phthalate (DBP) (0, 15, and 35 mu g DBP/L) for 22 d and analyzed for changes in nesting behavior, plasma androgen concentrations, spiggin concentrations, and steroidogenic gene expression. Plasma testosterone concentrations were significantly higher in males from the 35 mu g DBP/L group compared with the solvent control, whereas plasma 11-ketotestosterone concentrations were not significantly affected. Expression of steroid acute regulatory protein and 3 beta-hydroxysteroid dehydrogenase remained unchanged. Spiggin concentrations were significantly lower in the males exposed to 35 mu g DBP/L. Nest building appeared to be slower in some males exposed to DBP, but this was not statistically significant. These results suggest that DBP has anti-androgenic effects in fish. However, further research is required to firmly establish the consequences of chronic DBP exposure in fish

Organochlorine Pesticide Residues in Sediments and Waters from Cocoa Producing Areas of Ondo State, Southwestern Nigeria

Thisstudyinvestigatedlevelsoforganochlorinepesticide(OCP)residuesinwaterandsedimentsamplesfromelevenriversserving as drinking water sources and receiving runoff from nearby cocoa plantations in Ondo State, Nigeria. Twenty-two composite samplesofsurfacewaterandsediments(0–3cm)werecollectedrandomlyusinggrabtechniqueandreplicatedthriceperseason. The efficiency of the two techniques [supercritical fluid extraction (SFE) and liquid/liquid extraction (LLE)] was evaluated with percentageanalyterecoveries 98.17 ± 0.03 to 134.72 ± 0.02 forSFEand 84.82 ± 3.32 to1102.83 ± 3.17 forLLE.Determinationof OCPsbygaschromatographywithelectroncapturedetectiongavehigherconcentrationsforsedimentscomparedtotheequivalent water samples. The commonly occurring pesticide residues in the sediments were (range