2,150 research outputs found
Magnetostratigraphy of the Lower Triassic beds from Chaohu(China) and its implications for the Induan–Olenekian stage boundary.
A magnetostratigraphic study was performed on the lower 44 m of the West Pingdingshan section near Chaohu city, (Anhui province, China) in order to provide a magnetic polarity scale for the early Triassic. Data from 295 paleomagnetic samples is integrated with a detailed biostratigraphy and lithostratigraphy. The tilt-corrected mean direction from the West Pingdingshan section, passes the reversal and fold tests. The overall mean direction after tilt correction is D=299.9º, I=18.3º (κ=305.2, α95=1.9, N=19). The inferred paleolatitude of the sampling sites (31.6ºN, 117.8ºE) is about 9.4º, consistent with the stable South China block (SCB), though the declinations indicate some 101o counter-clockwise rotations with respect to the stable SCB since the Early Triassic. Low-field anisotropy of magnetic susceptibility indicates evidence of weak strain. The lower part of the Yinkeng Formation is dominated by reversed polarity, with four normal polarity magnetozones (WP2n to WP5n), with evidence of some thinner (<0.5 m thick) normal magnetozones. The continuous magnetostratigraphy from the Yinkeng Formation, provides additional high-resolution details of the polarity pattern through the later parts of the Induan into the lowest Olenekian. The magnetostratigraphic and biostratigraphic data shows the conodont marker for the base of the Olenekian (first presence of Neospathodus waageni) is shortly prior to the base of normal magnetozone WP5n. This provides a secondary marker for mapping the base of the Olenekian into successions without conodonts. This section provides the only well-integrated study from a Tethyan section across this boundary, but problems remain in definitively relating this boundary into Boreal sections with magnetostratigraphy
Construction of a medical informatics thesaurus
pre-printMedical Informatics needs a specific terminology that reflects the multi-disciplinary nature of the field and can rapidly change as the discipline evolves. Using the four primary methods of thesaurus construction, a group at the University of Missouri- Columbia is developing a thesaurus that meets these criteria and includes both user and literary warrant. The steps in construction include using existing thesauri, medical informatics literature, and the terminology of experts to produce a thesaurus arranged within a hierarchical structure
Elliptic aspects of statistical mechanics on spheres
Our earlier results on the temperature inversion properties and the
ellipticisation of the finite temperature internal energy on odd spheres are
extended to orbifold factors of odd spheres and then to other thermodynamic
quantities, in particular to the specific heat. The behaviour under modular
transformations is facilitated by the introduction of a modular covariant
derivative and it is shown that the specific heat on any odd sphere can be
expressed in terms of just three functions. It is also shown that the free
energy on the circle can be written elliptically.Comment: 22 pages. JyTe
Identifying high-mobility tetracene derivatives using a non-adiabatic molecular dynamics approach
The search for conductive soft matter materials with significant charge mobility under ambient conditions has been a major priority in organic electronics (OE) research. Alkylated tetracenes are promising cost-effective candidate molecules that can be synthesized using wet chemistry methods, resulting in columnar single crystals with pronounced structural stability at and above room temperature. A remarkable characteristic of these materials is the capability of tuning the tetracene core intracolumnar stacking pattern and the crystal melting point via the side chain length and type modifications. In this study, we examine the performance of a series of alkylated tetracenes as hole conducting materials using a novel atomistic simulation technique that allows us to predict both the charge transport mechanism and mobilities. Our simulations demonstrate that molecular wires of alkylated tetracenes are capable of polaronic hole conduction at room temperature, with mobility values ranging up to 21 cm2 V−1 s−1, thus rendering such materials a highly promising choice for flexible OE applications. As regards the charge transfer robustness, two promising tetracene derivatives are identified with the capability of seamless inter-wire polaron delocalization, alleviating possible transfer bottlenecks due to local molecular defects. Our findings suggest that alkylated tetracenes offer an attractive route towards flexible columnar OE materials with unprecedented hole mobilitie
Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes
A number of cell surface molecules with specificity to tumour cells have been identified and monoclonal antibodies (mAb) to some of these antigens have been used for targeting tumour cells in vivo. We have sought to link the powerful effector mechanisms of cytotoxic T-cells with the specificity of mAb, by targeting recombinant HLA class I molecules to tumour cells using an antibody delivery system. Soluble recombinant MHC class I/peptide complexes including HLA-A2.1 refolded around an immunodominant peptide from the HIV gag protein (HLA-A2/gag) were synthesized, and the stability of these complexes at 37°C was confirmed by enzyme-linked immunosorbent assay using a conformation-specific antibody. MHC class I-negative lymphoma cells (Daudi) were labelled with a biotinylated mAb specific for a cell surface protein (anti-CD20) then linked to soluble biotinylated HLA-A2/gag complexes using an avidin bridge. Flow cytometry revealed strong labelling of lymphoma cells with HLA-A2/gag complexes (80-fold increase in mean channel fluorescence). CTL specific for HLA-A2/gag efficiently lysed complex-targeted cells, while control CTL (specific for an HLA-A2.1-restricted epitope of melan-A) did not. Similarly, SK-mel-29 melanoma cells were also efficiently lysed by HLA-A2/gag-specific CTL when HLA-A2/gag complexes were linked to their surface via the HMW-MAA specific anti-melanoma antibody 225.28s. With further consideration to the in vivo stability of the MHC class I/peptide complexes, this system could prove a new strategy for the immunological therapy of cancer. © 2000 Cancer Research Campaig
Magnetic-field dependence of electron spin relaxation in n-type semiconductors
We present a theoretical investigation of the magnetic field dependence of
the longitudinal () and transverse () spin relaxation times of
conduction band electrons in n-type III-V semiconductors. In particular, we
find that the interplay between the Dyakonov-Perel process and an additional
spin relaxation channel, which originates from the electron wave vector
dependence of the electron -factor, yields a maximal at a finite
magnetic field. We compare our results with existing experimental data on
n-type GaAs and make specific additional predictions for the magnetic field
dependence of electron spin lifetimes.Comment: accepted for publication in PRB, minor changes to previous manuscrip
Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury
Severe lung damage in COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways and genes present across the spectrum of histopathological damage in COVID-19 lung tissue. We applied correlation network-based approaches to deconvolve gene expression data from areas of interest within well preserved post-mortem lung samples from three patients. Despite substantial inter-patient heterogeneity we discovered evidence for a common immune cell signaling circuit in areas of severe tissue that involves crosstalk between cytotoxic lymphocytes and pro-inflammatory macrophages. Expression of IFNG by cytotoxic lymphocytes was associated with induction of chemokines including CXCL9, CXCL10 and CXCL11 which are known to promote the recruitment of CXCR3+ immune cells. The tumour necrosis factor (TNF) superfamily members BAFF ( TNFSF13B ) and TRAIL ( TNFSF10 ) were found to be consistently upregulated in the areas with severe tissue damage. We used published spatial and single cell SARS-CoV-2 datasets to confirm our findings in the lung tissue from additional cohorts of COVID-19 patients. The resulting model of severe COVID-19 immune-mediated tissue pathology may inform future therapeutic strategies. One Sentence Summary Spatial analysis identifies IFNγ response signatures as focal to severe alveolar damage in COVID-19 pneumonitis
Metallic Xenon, Molecular Condensates, and Superconductivity
A possibility of explaining the light absorption observed to occur under
pressure-induced xenon metallization as due to the transition to the
superconducting state is analyzed. The mechanism of the van der Waals bonding
is discussed.Comment: LaTeX 2.09 (RevTeX), 4 pages, 4 PostScript figures included in tex
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