Reward Allocation For Maximizing Energy Savings In A Transportation System

Transportation has a major impact on our society and environment, contributing 70% of U.S petroleum use, 28% of U.S. greenhouse gas (GHG) emissions, over 34,000 fatalities and 2.2 million injuries in 2013. Punitive approaches to used to tackle environmental issues in the transportation sector, such as congestion pricing have been well documented, although the use of incentives or rewards lags behind in comparison. In addition to the use of more fuel-efficient, alternate energy vehicles and various other energy reduction strategies; energy consumption can be lowered through incentivizing alternative modes of transportation. This paper focused on modifying travelers’ behavior by providing rewards to enable shifts to more energy-efficient modes, (e.g., from auto to either bus or bicycles). Optimization conditions are formulated for the problem to understand solution properties, and numerical tests are carried out to study the effects of system parameters (e.g., token budget and coefficient of tokens) on the optimal solutions (i.e., energy savings). The multinomial logit model is used to formulate the full problem, comprised of an objective function and constraint of a token budget ranging from $5,000-$10,000. Comparably, the full problem is computationally reduced by various parameterization strategies, in that the number of tokens assigned to all travelers’ is parameterized and proportional to the expected energy savings. An optimization solution algorithm is applied with a global and local solver to solve a lagrangian sub-problem and a duo of heuristic solution algorithms of the original problem. These were determined necessary to attain an optimal and feasible solution. Input data necessary for this analysis is obtained for the Town of Amherst, MA from the Pioneer Valley Planning Commission (PVPC). The results demonstrated strong evidence to conclude a positive correlation between the system’s energy savings and the aforementioned system parameters. The local and global solvers solution algorithm reduced the average energy consumption by 11.48% - 19.91% and12.79% – 21.09% consecutively for the identified token budget range from a base case scenario with no tokens assigned. The duo of lagrangian heuristic algorithms improved the full problems solution i.e., higher energy savings, when optimized over a local solver, while the parameterized problem formulations resulted in higher energy savings when compared to the full problems’ formulation solution over local solver, but higher energy savings compared over the global solver. The Computational run-time for the global and local solvers solution algorithm for the full problem formulation required 43 hours and 24 minutes consecutively, while the local solver for the lagrangian heuristics and parameterized problem solution algorithm took 13 minutes and 7 minutes consecutively. Future research on this paper will be comprised of a bi-level optimization problem formulation where a high level optimization aims at maximizing system-wide energy savings, while a low-level consumer surplus maximization problem is solved for each system user

Rural-Urban Differentials in the Attitude of Global Systems of Mobile Communication (GSM) Consumers to Merits and Demerits of GSM Technology in Ogun State, Nigeria

The advent of the Global System of Mobile Communication (GSM) in Nigeria has become the order of most day-to-day activities; however, consumers of GSM services through the use of cellular phones are faced with numerous problems in making use of the GSM technology. This study examined the attitude of respondents to the merits and demerits inherent in the use of cellular phones in rural and urban Ogun State of Nigeria. 70 respondents were randomly selected and interviewed in two local government areas of the State using a well-structured questionnaire, out of which 66 data set were eventually found useful. Data were collected and analyzed using simple descriptive [averages and percentages] and Chi-square statistics. Gender distribution shows significant difference in both locations at 5% probability level (p \u3c 0.05), however the respondents were predominantly male. Significant proportion of the urban dwellers (at 5% probability level i.e. p \u3c 0.05) were more learned (formally) than the ones in the rural area while the distribution of vocation of respondents was significantly different in both location at 1% probability level (p \u3c 0.01) with most respondents being farmers in the rural area. Both rural and urban respondents believed cellular phone use is advantageous with a slightly higher index for urban location than for the rural location. Furthermore, respondents in the urban location viewed cellular phone technology as disadvantageous with respect to health implications indicating a slightly higher index than for the respondents in the rural location. Therefore, it was recommended that more attention should be paid to educating the populace on the safe use of cellular phones in all locations of the study area

Numerical solution of Black–Scholes Partial Differential Equation using Direct solution of second-order Ordinary Differential Equation with two-step hybrid Block Method of Order seven

This paper proposes a new numerical solution of Black-Scholes Partial Differential Equation using Direct solution of second-order Ordinary Differential Equation ODE with two-step hybrid Block Method of Order seven directly. The method is developed using interpolation and collocation techniques. The use of the power series approximate solution as an interpolation polynomial and its second derivative as a collocation equation is considered in deriving the method. Properties of the method such as zero stability, order, consistency, convergence and region of absolute stability are investigated The new method is then applied to solve Black–Scholes equation after converting it to the system of second-order ordinary differential equations and the accuracy is better when compared with the existing methods in terms of error

Shortest Route: A Mobile Application for Route Optimization using Digital Map

Businesses that have embarked on using digital maps have been able to increase employee productivity, communicate visually; reduce cost of logistics, planning, resources by more than half of its initial cost. Many industries that have benefitted from this technology include Online Markets, Delivery companies, Agriculture, Real Estate, Engineering, Media, Energy and Utilities, Insurance, Architecture. Seeing this need especially in Nigeria where cost of logistics is high, resources are wasted in the process and productive time is also wasted leading to fatigue and low outcome; there is therefore the need for route optimization for businesses in Nigeria. TSP (Travelling Salesman Problem) - Nearest Neighbour Algorithm is used to solve the problem of route optimization on Google MAP. This study developed a mobile application in Java, HTML and Google SDKs, to find shortest route between various numbers of locations enumerated on digital maps on a smart device. The application was implemented successfully on the Android Operating System for mobile devices. Anyone can download it from the Google play store, install and freely use

Relationship between rickets and incomplete distal renal tubular acidosis in children

<p>Abstract</p> <p>Background</p> <p>In the Sub Saharan Africa Rickets has now been established to be due primarily to calcium deficiency and sometimes in combination with vitamin D deficiency. The main thrust of management is calcium supplementation with or without vitamin D. An observation was made that some children with nutritional rickets do not respond to this management modality. The recently reported high prevalence of Incomplete Distal Renal Tubular Acidosis (idRTA) in adults with osteoporosis as brought to fore the possibility of this being a possible cause of calcium wastage and therefore the poor response in these group of children with rickets.</p> <p>Aim</p> <p>To determine the prevalence of idRTA amongst a cohort of subjects with rickets</p> <p>To show a relationship between rickets and incomplete distal renal acidosis</p> <p>To determine the response of children with rickets and idRTA to addition of Shohl's solution to therapy</p> <p>Methodology</p> <p>Two separate cohorts of children with rickets performed the ammonium chloride loading test to detect those with incomplete renal tubular acidosis. Following identification for idRTA, Shohl's solution was added to therapy of calcium and vitamin D supplementation and their response compared to those without idRTA on calcium and vitamin D supplementation solely.</p> <p>Results</p> <p>50 children with rickets aged from two to six years of age and composed of 29 females and 21males were investigated. Incomplete renal tubular acidosis was found in 38% of them. Prevalence of idRTA was highest amongst those aged 3-6 years of age. Those with idRTA had worse limb deformities, biochemical and radiological parameters than those who hadn't. Rate of response on those with idRTA treated with Shohl's solution was at par with those without idRTA.</p> <p>Conclusion</p> <p>Incomplete idRTA exist amongst children with rickets and should be looked out for in severe rickets and older children. Treatment of idRTA will lead to optimal response and healing of rickets.</p

Fasting Blood Glucose Profile among Secondary School Adolescents in Ado-Ekiti, Nigeria

Background. Over the past two decades there has been an increase in type 2 diabetes mellitus (T2DM) in children. Baseline data is needed to assess the impact of changing lifestyles on Ado-Ekiti, a previously semiurban community in Southwest Nigeria. This study was therefore conducted to assess the fasting blood glucose (FBG) of adolescents in Ado-Ekiti, Nigeria. Methodology. This was a cross-sectional study involving 628 adolescents from three different secondary schools in Ado-Ekiti, Nigeria. With parental consent, volunteers completed a structured questionnaire, and an overnight FBG was measured. Results. There were 346 males and 282 females (male : female ratio = 1.2 : 1). Their ages ranged from 10 to 19 years (mean age: 14.2±1.7 years). Four hundred and forty-four (70.7%) had normal FBG, while 180 (28.7%) and 4 (0.6%) had FBG in the prediabetic and diabetic range, respectively. Female gender, age group 10–14 years, and family history of obesity were significantly associated with impaired FBG (P value <0.001, <0.001, and 0.045, resp.). Conclusion. Impaired FBG is common among secondary school adolescents and it is more prevalent among younger female adolescents (10–14 years) with positive family history of obesity

Mouse models of altered gonadotrophin action: insight into male reproductive disorders

The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic–pituitary–gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action.Fil: Jonas, Kim C.. Imperial College London; Reino UnidoFil: Oduwole, Olayiwola O.. Imperial College London; Reino UnidoFil: Peltoketo, Hellevi . University of Oulu; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Huhtaniemi, Ilpo T. . Imperial College London; Reino Unido. University of Turku; Finlandi

Artemisinin-naphthoquine versus Artemether-lumefantrine for treating uncomplicated plasmodium falciparum malaria in children: A randomized controlled trial of efficacy and safety

Introduction: Artemether-lumefantrine (AL), the most frequently prescribed ACTs for uncomplicated P. falciparum malaria, requires multiple doses which may militate against adherence. It is necessary to evaluate the efficacy and safety of single dose ACT like Artemisininnaphthoquine (ANQ) to enhance adherence.Methods: This was an open label randomized controlled clinical trial. Eligible children were assigned to receive either a single dose of ANQ or six doses of AL following parental consent. A total of 108 children aged 5 – 14years with uncomplicated falciparum malaria were enrolled and assigned as follows: 58 (ANQ) and 50 (AL). Participants were observed for 28 days and clinical and parasitological assessments carried out. Outcomes were  assessed based on World Health Organization protocol.Results: A total of 97 patients completed the study. Overall 28-day cure  rate was 87.0% (47/54) and 81.4% (35/43) for ANQ and AL respectively. One patient (2.2%) in the AL group had Early Treatment Failure while seven (16.3%) had Late Parasitological Failure (LPF). LPF was also reportedin seven (13.0%) patients in the ANQ group. There was no Late Clinical Failure. A mild selflimiting papular rash was noted in one child in ANQ group. There was no serious adverse event.Conclusions: The therapeutic efficacies of ANQ and AL were comparable.A more robust, adequately powered, dose optimization study with  PCR-confirmed parasitological  outcome measures is needed.Key words: Malaria, artemetherlume f a nt r ine , a r t emi s i nin -naphthoquine, adherence, single and multiple dose therap

The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited

Spermatogenesis and folliculogenesis involve cell-cell interactions and gene expression orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH regulates the proliferation and maturation of germ cells independently and in combination with LH. In humans, the requirement for high intratesticular testosterone (T) concentration in spermatogenesis remains both a dogma and an enigma, as it greatly exceeds the requirement for androgen receptor (AR) activation. Several data have challenged this dogma. Here we report our findings on a man with mutant LH beta subunit (LH beta) that markedly reduced T production to 1-2% of normal., but despite this minimal LH stimulation, T production by scarce mature Leydig cells was sufficient to initiate and maintain complete spermatogenesis. Also, in the LH receptor (LHR) knockout (LuRKO) mice, low-dose T supplementation was able to maintain spermatogenesis. In addition, in antiandrogen-treated LuRKO mice, devoid of T action, the transgenic expression of a constitutively activating follicle stimulating hormone receptor (FSHR) mutant was able to rescue spermatogenesis and fertility. Based on rodent models, it is believed that gonadotropin-dependent follicular growth begins at the antral stage, but models of FSHR inactivation in women contradict this claim. The complete loss of FSHR function results in the complete early blockage of folliculogenesis at the primary stage, with a high density of follicles of the prepubertal type. These results should prompt the reassessment of the role of gonadotropins in spermatogenesis, folliculogenesis and therapeutic applications in human hypogonadism and infertility.</p