39 research outputs found
Formation of functional nanobiocatalysts with a novel and encouraging immobilization approach and their versatile bioanalytical applications
Aptamer-Nanoparticle Assembly for Logic-Based Detection
In this work, gold nanoparticles perform Boolean logic operations in response to two proangiogenic targets important in cancer diagnosis and treatment: PDGF and VEGF. In the absence of protein target, gold nanoparticles are initially dispersed as a red solution; the addition of target proteins causes nanoparticle aggregation, turning the solution blue, as well as the release of dye-labeled aptamer probes, which causes an increase in fluorescence. These outputs constitute an AND or OR gate for simultaneous protein detection. We believe this logic-gate-based detection system will become the basis for novel rapid, cheap, and reliable sensors for diagnostic applications
Aptamer-Nanoparticle Assembly for Logic-Based Detection
In this work, gold nanoparticles perform Boolean logic
operations
in response to two proangiogenic targets important in cancer diagnosis
and treatment: PDGF and VEGF. In the absence of protein target, gold
nanoparticles are initially dispersed as a red solution; the addition
of target proteins causes nanoparticle aggregation, turning the solution
blue, as well as the release of dye-labeled aptamer probes, which
causes an increase in fluorescence. These outputs constitute an AND
or OR gate for simultaneous protein detection. We believe this logic-gate-based
detection system will become the basis for novel rapid, cheap, and
reliable sensors for diagnostic applications