Changes occurring in plain, straining and winter yoghurt during the storage periods

In this study, winter yoghurt, straining yoghurt and yoghurt samples produced from homogenized and non-homogenized sheep and a mixture of sheep and cows milks were evaluated during the storage periods. Winter yoghurt, straining yoghurt and yoghurt samples were stored in sterile jars in the refrigerator (4°C). Some chemical and physical analyses were made to determine the effect of milk types (cow and sheep), homogenization (homogenized and nonhomogenized) and storage times in winter yoghurt samples on the 3rd, 7th, 15th, 30th, 60th, 90th, 120th, 150th and 180th days, in straining yogurt samples on the 3rd, 7th, 15th, 30th and 60th days and in plain yoghurt samples on 3rd, 7th, 15th and 30th. Contents of the average dry matter, fat, protein, pH, titratable acidity, lipolysis, proteolysis, clot firmness and stickiness in winter yoghurt samples were determined as follows respectively: 23.79, 9.29, 8.99, 3.96, 1.75, 0.72%, 97.91 mM, 9.44 N and 5.50 N. No serum separation existed in winter yoghurts.Key words: Winter yoghurt, storage, milk type, homogenizatio

Laparoscopic artificial insemination in dairy sheep with chilled semen stored for up to 26 h

Adult East Freisan crossbred (n = 220) and Chios ewes (n = 105) were divided into four groups and inseminated with chilled semen, which had been stored for 7, 13, 20 or 26 h at 5°C. Unilateral intrauterine insemination (50 x 106 spermatozoa in 0.25 ml) was performed with the aid of a laparoscope. Inseminations were carried out 48 – 52 h after pessary removal (30 mg FGA) without detecting estrus. The lambing rates after intrauterine insemination with chilled semen were found to be similar in East Fresian crossbred (40%) and Chios ewes (30%). Intrauterine insemination with chilled semen stored up to 26 h resulted in similar lambing rates; whereas, fertility of Chios ewes tended to decline with increased holding time of chilled semen. From this study, it is concluded that decreasing the storage time of chilled semen at 5°C improves pregnancy in Chios ewes and that East Fresian crossbred ewe’s conception rates to intrauterine insemination with chilled semen was relatively higher than Chios ewes.Key words: Dairy sheep, chilled semen, time of insemination, lambing rate

Editorial of Special Issue of National Identities: Alevism as an ethno-religious identity: Contested boundaries

No abstract for editorial but this is the opening paragraph: This special issue on Alevism and trans/national Alevi identity critically engages with the relationship between religion, ethnicity and national identity. The core issues are as follows: • how ethnicity and religion are conceptualised for a relatively invisible ethnic group in different national contexts; • how religion and ethnicity intersect when Alevism is both a faith and an ethnic identity, especially when conceptions of that identity are contested; • how identity is shaped through state policies within different national policy contexts and how etic definitions of minority communities are constructed by the state or other agencies with the power to impose them on the community in contrast to the emic or self-definitions of Aleviness from within the Alevi community; • how despite the fragmented, heterogeneous nature of Alevi communities, there is also a sense of a single, transnational imaginary community, at least for the purposes of political assimilation/integration and activism; • how education and other arenas of political, religious and cultural engagement at local, national and transnational levels create the possibilities, both positively and negatively, for future action/policy to situate minority ethnic communities

Cone beam computed tomography evaluation of ponticulus posticus in patients with cleft lip and palate: a retrospective radio-anatomic study

Background: Ponticulus posticus (PP) is an abnormal bony bridge on the atlas. It plays a significant role in patients undergoing C1 lateral mass screw procedure. Patients with cleft lip and palate (CLP) have higher risk than patients in general population for the appearance of cervical vertebral anomalies. The purpose of the this study was twofold: to determine the prevalence and characteristics of PP in patients with CLP, and to compare the findings with patients in general population using cone beam computed tomography. Materials and methods: Cone beam computed tomography images from 54 individuals who had undergone surgical repair of cleft lip and/or palate were analysed as the study group. For comparison purposes a control group was randomly selected from 108 patients and matched with the CLP subjects. Results: Although 12 of the 54 (22.3%) patients with surgically repaired cleft lip and/or palate in the study group were identified to have PP, only 10 of the 108 (9.2%) patients in the control group had PP. The distribution of the presence of PP between the groups was statistically significant. Conclusions: Ponticulus posticus is an important anomaly and the presence of PP is important for patients. PP can have clinical significance in cervical spine surgery as this study has indicated that the likelihood of encountering PP is higher in patients with CLP. We suggest that PP should be taken into account prior to cervical vertebral surgery in patients with CLP. (Folia Morphol 2018; 77, 1: 72–78)

When local poverty is more important than your income: Mental health in minorities in inner cities

Volkswagen Foundation and the German Federal Ministry for Education and Research . Grant Number: BMBF 01 EL080

Die Anwendung der Virtuellen Realität in der Behandlung psychischer Störungen

Background: Virtual reality (VR) enables immersion in an interactive digital world with realistic experiences, that can be applied for controlled and personalized interventions. This review summarizes the current research on VR in the treatment of mental disorders. Methods Selective literature search in PubMed and Google Scholar. Results An increasing number of publications report the therapeutic application of VR for the treatment of mental disorders. Most VR applications are based on established therapy approaches, such as exposure therapy. According to meta-analytic data, virtual exposure therapy (VRET) for specific phobia and agoraphobia with panic disorder is as effective as traditional in vivo exposure therapy. VRET for the treatment of social phobia is significantly more effective than waitlist and placebo control groups with, however, currently inconsistent metanalytic results when compared to in vivo exposure therapy. VRET for the treatment of posttraumatic stress disorder (PTSD) is similar in effectiveness compared to active psychotherapy. For psychosis, positive results have been reported for the VR-based treatment of auditory verbal hallucinations. For patients with a substance use disorder, VR can induce craving, with still unverified diagnostic and therapeutic relevance. Conclusions VRET can broaden the psychotherapy options for anxiety disorders. Encouraging results of VR-based treatments for psychosis and PTSD indicate the need for further research concerning its effectiveness and safety. In the field of substance use disorders, evaluation of clinical-orientated VR applications is needed.Hintergrund: Die Virtuelle Realität (VR) ermöglicht das Eintauchen in eine interaktive, digitale Welt mit realitätsnahen Erfahrungen, die im Rahmen therapeutischer Intervention kontrolliert und personalisiert eingesetzt werden können. In dieser Übersichtsarbeit werden die aktuellen Forschungsergebnisse zur VR in der Behandlung psychischer Störungen zusammengefasst. Methode: Selektive Literaturrecherche in PubMed und über Google Scholar. Ergebnisse: Eine zunehmende Anzahl von Publikationen beschreibt unterschiedliche Einsatzformen der VR in der Behandlung psychischer Störungen. Die Mehrheit der VR-Anwendungen basiert auf Adaptionen bereits etablierter psychotherapeutischer Methoden, insbesondere der Expositionstherapie. Die Virtuelle Expositionstherapie (VRET) in der Behandlung der spezifischen Phobie und der Agoraphobie mit Panikstörung ist laut metaanalytischen Daten gleich wirksam wie die traditionelle Expositionstherapie in vivo. VRET für die soziale Phobie ist signifikant wirksamer als Warte- oder Placebo-Kontrollgruppen, aber im Vergleich zur Expositionstherapie in vivo sind die metaanalytischen Befunde derzeit inkonsistent. VRET bei der posttraumatischen Belastungsstörung (PTBS) ist laut Metaanalysen gleich wirksam wie eine aktive Psychotherapie. Für die VR-basierte Behandlung der psychotischen Störungen gibt es positive Befunde bezogen auf Reduktion des Stimmenhörens. Bei Patienten mit einer Abhängigkeitserkrankung kann mittels VR „craving“ induziert werden mit noch unzureichend belegter diagnostischer und therapeutischer Relevanz. Schlussfolgerung: Die VRET kann als Erweiterung der psychotherapeutischen Behandlung der Angststörungen angeboten werden. Vielversprechende Befunde der VR-basierten Therapien der PTBS und der psychotischen Störungen implizieren den Bedarf weiterer Forschung zur Klärung ihrer Effektivität und Sicherheit. Im Bereich der Abhängigkeitserkrankungen ist die Evaluation klinisch orientierter VR-Anwendungen erforderlich

A novel selection of optimal statistical features in the DWPT domain for discrimination of ictal and seizure-free electroencephalography signals

Properly determining the discriminative features which characterize the inherent behaviors of electroencephalography (EEG) signals remains a great challenge for epileptic seizure detection. In this present study, a novel feature selection scheme based on the discrete wavelet packet decomposition and cuckoo search algorithm (CSA) was proposed. The normal as well as epileptic EEG recordings were frst decomposed into various frequency bands by means of wavelet packet decomposition, and subsequently, statistical features at all developed nodes in the wavelet packet decomposition tree were derived. Instead of using the complete set of the extracted features to construct a wavelet neural networks-based classifer, an optimal feature subset that maximizes the predictive competence of the classifer was selected by using the CSA. Experimental results on the publicly available benchmarks demonstrated that the proposed feature subset selection scheme achieved promising recognition accuracies of 98.43–100%, and the results were statistically signifcant using z-test with p value <0.0001

The HLA Class II Allele Allele DRB1*15 is over-represented in patients with Idiopathic Pulmonary Fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident in many afflicted patients. We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be present in IPF patients. METHODS/PRINCIPAL FINDINGS: HLA alleles were determined in subpopulations of IPF and normal subjects using molecular typing methods. HLA-DRB1*15 was over-represented in a discovery cohort of 79 Caucasian IPF subjects who had lung transplantations at the University of Pittsburgh (36.7%) compared to normal reference populations. These findings were prospectively replicated in a validation cohort of 196 additional IPF subjects from four other U.S. medical centers that included both ambulatory patients and lung transplantation recipients. High-resolution typing was used to further define specific HLA-DRB1*15 alleles. DRB1*1501 prevalence in IPF subjects was similar among the 143 ambulatory patients and 132 transplant recipients (31.5% and 34.8%, respectively, p = 0.55). The aggregate prevalence of DRB1*1501 in IPF patients was significantly greater than among 285 healthy controls (33.1% vs. 20.0%, respectively, OR 2.0; 95%CI 1.3-2.9, p = 0.0004). IPF patients with DRB1*1501 (n = 91) tended to have decreased diffusing capacities for carbon monoxide (DL(CO)) compared to the 184 disease subjects who lacked this allele (37.8±1.7% vs. 42.8±1.4%, p = 0.036). CONCLUSIONS/SIGNIFICANCE: DRB1*1501 is more prevalent among IPF patients than normal subjects, and may be associated with greater impairment of gas exchange. These data are novel evidence that immunogenetic processes can play a role in the susceptibility to and/or manifestations of IPF. Findings here of a disease association at the HLA-DR locus have broad pathogenic implications, illustrate a specific chromosomal area for incremental, targeted genomic study, and may identify a distinct clinical phenotype among patients with this enigmatic, morbid lung disease

The HLA class II allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident in many afflicted patients. We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be present in IPF patients. Methods/Principal Findings: HLA alleles were determined in subpopulations of IPF and normal subjects using molecular typing methods. HLA-DRB1*15 was over-represented in a discovery cohort of 79 Caucasian IPF subjects who had lung transplantations at the University of Pittsburgh (36.7%) compared to normal reference populations. These findings were prospectively replicated in a validation cohort of 196 additional IPF subjects from four other U.S. medical centers that included both ambulatory patients and lung transplantation recipients. High-resolution typing was used to further define specific HLA-DRB1*15 alleles. DRB1*1501 prevalence in IPF subjects was similar among the 143 ambulatory patients and 132 transplant recipients (31.5% and 34.8%, respectively, p = 0.55). The aggregate prevalence of DRB1*1501 in IPF patients was significantly greater than among 285 healthy controls (33.1% vs. 20.0%, respectively, OR 2.0; 95%CI 1.3-2.9, p = 0.0004). IPF patients with DRB1*1501 (n = 91) tended to have decreased diffusing capacities for carbon monoxide (DLCO) compared to the 184 disease subjects who lacked this allele (37.8±1.7% vs. 42.8±1.4%, p = 0.036). Conclusions/Significance: DRB1*1501 is more prevalent among IPF patients than normal subjects, and may be associated with greater impairment of gas exchange. These data are novel evidence that immunogenetic processes can play a role in the susceptibility to and/or manifestations of IPF. Findings here of a disease association at the HLA-DR locus have broad pathogenic implications, illustrate a specific chromosomal area for incremental, targeted genomic study, and may identify a distinct clinical phenotype among patients with this enigmatic, morbid lung disease