La enseñanza de la traducción especializada. Corpus textuales de traductores en formación con etiquetado de errores

This paper describes the method used in teaching specialised translation in the English Language Translation Master’s programme at Masaryk University. After a brief description of the courses, the focus shifts to translation learner corpora (TLC) compiled in the new Hypal interface, which can be integrated in Moodle. Student translations are automatically aligned (with possible adjustments), PoS (part-of-speech) tagged, and manually error-tagged. Personal student reports based on error statistics for individual translations to show students’ progress throughout the term or during their studies in the four-semester programme can be easily generated. Using the data from the pilot run of the new software, the paper concludes with the first results of the research examining a learner corpus of translations from Czech into English.En el presente trabajo se describe el método que se ha seguido para enseñar traducción especializada en el Máster de Traducción en Lengua Inglesa que se imparte en la Universidad de Masaryk. Tras una breve descripción de las asignaturas, nos centramos en corpus textuales de traductores en formación (translation learner corpora, TLC) recopilado en la nueva interfaz Hypal, que se puede incorporar en Moodle. Las traducciones realizadas por los alumnos se alinean de forma automática (con posibles modificaciones) y reciben un etiquetado gramatical y un etiquetado manual de errores. Es posible generar de manera sencilla informes sobre los alumnos con información estadística sobre errores en las traducciones individuales para mostrar su progreso durante el cuatrimestre o el programa completo. En función de los datos obtenidos en la prueba piloto del nuevo software, este trabajo presenta los primeros resultados del estudio a través de un corpus de traducciones de aprendices del checo al inglés

In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia

We applied the patch-seq technique to harvest transcripts from individual microglial cells from cortex, hippocampus and corpus callosum of acute brain slices from adult mice. After recording membrane currents with the patch-clamp technique, the cytoplasm was collected via the pipette and underwent adapted SMART-seq2 preparation with subsequent sequencing. On average, 4138 genes were detected in 113 cells from hippocampus, corpus callosum and cortex, including microglia markers such as Tmem119, P2ry12 and Siglec-H. Comparing our dataset to previously published single cell mRNA sequencing data from FACS-isolated microglia indicated that two clusters of cells were absent in our patch-seq dataset. Pathway analysis of marker genes in FACS-specific clusters revealed association with microglial activation and stress response. This indicates that under normal conditions microglia in situ lack transcripts associated with a stress-response, and that the microglia-isolation procedure by mechanical dissociation and FACS triggers the expression of genes related to activation and stress

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Color and polarization provide complementary information about the world and are detected by specialized photoreceptors. However, the downstream neural circuits that process these distinct modalities are incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed the synaptic targets of the photoreceptors specialized to detect color and skylight polarization in Drosophila, and we have used light microscopy to confirm many of our findings. We identified known and novel downstream targets that are selective for different wavelengths or polarized light, and followed their projections to other areas in the optic lobes and the central brain. Our results revealed many synapses along the photoreceptor axons between brain regions, new pathways in the optic lobes, and spatially segregated projections to central brain regions. Strikingly, photoreceptors in the polarization-sensitive dorsal rim area target fewer cell types, and lack strong connections to the lobula, a neuropil involved in color processing. Our reconstruction identifies shared wiring and modality-specific specializations for color and polarization vision, and provides a comprehensive view of the first steps of the pathways processing color and polarized light inputs

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is a free radical, which is toxic for all cells at high concentrations. To target an exaggerated NO release, we tested a library of 16 544 chemical compounds for their effect on lipopolysaccharide (LPS)-induced NO release in cell line and primary neonatal microglia. We identified a compound (C1) which significantly reduced NO release in a dose-dependent manner, with a low IC50 (252 nM) and no toxic side effects in vitro or in vivo. Target finding strategies such as in silico modelling and mass spectroscopy hint towards a direct interaction between C1 and the nitric oxide synthase making C1 a great candidate for specific intra-cellular interaction with the NO producing machinery

Lineární izolační zesilovač

Import 19/06/2008Prezenční448 - Katedra elektronikyNeuveden

AC Power Source / Power Analyzer

Import 29/09/2010Tato diplomová práce se zabývá střídavým zdrojem / analyzátorem od firmy Agilent. První část diplomové práce se zabývá schopnostmi střídavého zdroje. Hlavní důraz je kladen na odzkoušení těchto schopností praktickým měřením. V další častí jsou využity měřící schopnosti zdroje, kdy jsou proměřeny vlastnosti dvou pulzního usměrňovače, řízeného dvou pulzního usměrňovače a zářivky, v různých zapojeních. Díky možnosti vytvořit takřka jakýkoliv signál, je otestována UPS. Součástí této práce je rovněž návod k měření na dvou pulzním řízeném usměrňovači, UPS a zářivce, v různých zapojeních.This thesis deals with the AC source / analyzer from Agilent Company. The first part deals with AC power capabilities. The main emphasis is on practical skills testing of these measurements. The other parts are used in measuring capabilities sources, which are measurement properties two-pulse rectifiers, controlled two-pulse rectifiers and fluorescent lamps in different circuits. With the ability to create almost any signal that is tested by UPS. Part of this work is also a guide to measure the controlled two-pulse rectifiers, UPS and fluorescent lamps in different circuits.Prezenční448 - Katedra elektronikyvelmi dobř