Ghana’S Pension Reforms in Perspective: Can the Pension Benefits Provide a House a Real Need of the Retiree?

The Government of Ghana enacted another pension reform in 2008 to establish a three-tier Pension Scheme with the objective of enhancing pension payments, financial independence to the retired worker and also for capital mobilization for national development. The purpose of any policy reforms that seeks to protect vulnerability of people must be significant to address identified inadequacies in a previous one. This paper is very critical of the new pension reform (Act 716) of 2008 as it provides unrealistic benefit to the pensioner to meet vital needs (i. e A HOUSE), a cultural demand, the lack of it, is killing many retirees in Ghana. The significance of the concept of building a house in Ghanaian cultural setting and retirees is discussed extensively. The mortgage industry which the Act or Scheme relies on is also evaluated. The conclusions are very revealing that the mortgage industry in Ghana is very expensive, unaffordable and therefore unreliable to provide any low cost housing to low income earners and many civil servants in Ghana. The paper proposes that a holistic Pension Scheme that is focused and targeted to identified cultural needs must be established. Financial independence as emphasized in the pension reform act is good but myopic and cannot guarantee longevity. Keywords: Pension Reforms, Retirees, House Mortgage

Lipid and Lipoprotein Levels in Type 2 Diabetes Patients Attending the Central Regional Hospital in the Cape Coast Metropolis of Ghana

Purpose: To ascertain the prevalence of dyslipidaemia in diabetics in Cape Coast.Methods: This preliminary outpatient-based cross-sectional study was conducted in 79 diabetic patients (22 males and 57 females) receiving treatment at the Central Regional Hospital (CRH) in the Cape Coast Metropolis. Serum lipid profiles of the fasting diabetic patients were determined between September, 2008 and May, 2009. In addition, demographic information, height and weight were measured and BMI was computed.Results: BMI was significantly (P = 0.001) higher in females than in males, but the mean values of all the remaining measured parameters were comparable (P>0.05) between the sexes. No significant (P>0.05) correlation was observed between age or BMI and cholesterol levels. Percentage dyslipidaemia ranged from 7.60% to 55.70% in the studysample. A significantly (P<0.05) higher proportion of females than males in the entire sample were overweight/obese, had higher levels of total cholesterol (TCHOL) and TRG. No significant difference (P>0.05) was observed between proportions of individuals in both sexes who exhibited higher LDL-c but lower levels of HDL-c..Conclusion: Lipid profile should be a routine test for all diabetics receiving treatment at the CRH to identify those at increased cardiovascular risk for immediate attention.Keywords: Dyslipidaemia, Cardiovascular, Cholesterol, Body mass inde

Knowledge and experience of a cohort of HIV-positive and HIV-negative Ghanaian women after undergoing human papillomavirus and cervical cancer screening.

BACKGROUND: Cervical cancer is the most common cancer in women in Ghana, but knowledge and experience of women who have had cervical screening is under-evaluated. This study examined knowledge and understanding of HPV and cervical cancer and evaluated experiences of screening in a cohort of women of mixed HIV status. METHODS: This was a mixed methods study using questionnaires and focus group discussions, with a knowledge score constructed from the questionnaire. HIV-positive and HIV-negative women were recruited from a larger cervical screening study in Ghana and were interviewed 6 months after receiving screening. Quantitative data was analyzed and triangulated with qualitative data following thematic analysis using the framework approach. RESULTS: A total of 131 women were included (HIV-positive, n = 60). Over 80% of participants had a knowledge score deemed adequate. There was no difference between HIV-status groups in overall knowledge scores (p = 0.1), but variation was seen in individual knowledge items. HIV-positive women were more likely to correctly identify HPV as being sexually-transmitted (p = 0.05), and HIV negative women to correctly identify the stages in developing cervical cancer (p = < 0.0001). HIV-positive women mostly described acquisition of HPV in stigmatising terms. The early asymptomatic phase of cervical cancer made it difficult for women to define "what" cancer was versus "what" HPV infection was. All women expressed that they found it difficult waiting for their screening results but that receiving information and counselling from health workers alleviated anxiety. CONCLUSIONS: Knowledge of women who had participated in a cervical screening study was good, but specific misconceptions existed. HIV-positive women had similar levels of knowledge to HIV-negative, but different misconceptions. Women expressed generally positive views about screening, but did experience distress. A standardized education tool explaining cervical screening and relevance specifically of HPV-DNA results in Ghana should be developed, taking into consideration the different needs of HIV-positive women

APOBEC3G variants and protection against HIV-1 infection in Burkina Faso

Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso. This case control study involved 708 seropositive and seronegative individuals. Genotyping was done by the TaqMan allelic discrimination method. Minor allele frequencies of rs6001417 (p<0.05), rs8177832 (P<0.05), and rs35228531 (P<0.001) were higher in seronegative subjects. The rs6001417 and rs8177832 SNPs were associated with HIV-1 infection in an additive model (P<0.01). Furthermore the SNP rs35228531 was also associated with HIV-1 infection in a dominant model (P<0.001). Odds ratio analysis of genotypes and alleles of the different APOBEC3G variants showed that there is a strong association between the minor genetic variants, genotype of the three SNPs, and HIV-1 status. Haplotype analysis demonstrated that rs6001417, rs8177832, and rs35228531 are in linkage disequilibrium. The haplotype GGT from the rs6001417, rs8177832 and rs35228531 respectively has a protective effect OR = 0.54 [0.43-0.68] with P<0.001. There was also associations between the haplotypes GGC OR = 1.6 [1.1;-2.3] P<0.05, and CGC OR = 5.21 [2.4-11.3] P<0.001, which increase the risk of infection by HIV-1 from almost two (2) to five (5) fold. This study demonstrates an association of rs6001417, rs8177832, and rs35228531 of APOBEC3G with HIV-1 infection in a population from Burkina Faso

Informed Consent under the Ghana Health Service Patients Charter: Practice and Awareness

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Novel <i>GREM1 </i>Variations in Sub-Saharan African Patients With Cleft Lip and/or Cleft Palate

Objective: Cleft lip and/or cleft palate (CL/P) are congenital anomalies of the face and have multifactorial etiology, with both environmental and genetic risk factors playing crucial roles. Though at least 40 loci have attained genomewide significant association with nonsyndromic CL/P, these loci largely reside in noncoding regions of the human genome, and subsequent resequencing studies of neighboring candidate genes have revealed only a limited number of etiologic coding variants. The present study was conducted to identify etiologic coding variants in GREM1, a locus that has been shown to be largely associated with cleft of both lip and soft palate. Patients and Method: We resequenced DNA from 397 sub-Saharan Africans with CL/P and 192 controls using Sanger sequencing. Following analyses of the sequence data, we observed 2 novel coding variants in GREM1. These variants were not found in the 192 African controls and have never been previously reported in any public genetic variant database that includes more than 5000 combined African and African American controls or from the CL/P literature. Results: The novel variants include p.Pro164Ser in an individual with soft palate cleft only and p.Gly61Asp in an individual with bilateral cleft lip and palate. The proband with the p.Gly61Asp GREM1 variant is a van der Woude (VWS) case who also has an etiologic variant in IRF6 gene. Conclusion: Our study demonstrated that there is low number of etiologic coding variants in GREM1, confirming earlier suggestions that variants in regulatory elements may largely account for the association between this locus and CL/P. </jats:sec

Hydrothermal alteration and mineralisation at the Mt Carlton high-sulphidation Au- Ag-Cu epithermal deposit (NE Queensland, Australia)

The Mt Carlton high-sulphidation Au-Ag-Cu deposit is located in the northern Bowen Basin, NE Queensland (Australia). High-grade mineralisation is confined to NE-trending, steeply dipping (75-90°) structures, and is hosted in a rhyodacitic unit of the Lizzie Creek Volcanic Group (Early Permian). The core of the hydrothermal system shows silicic alteration, with variable amounts of alunite (disseminated-and vein-type), anhydrite and pyrite. Outwards, the silicic zone progressively grades into an envelope of quartz- alunite-barite-pyrite → quartz-dickite-kaolinite-pyrite → illite-montmorillonite-pyrite alteration. After the alteration, the majority of metals were deposited in an initial stage of high-sulphidation mineralisation, dominated by enargite-luzonite-pyrite. This stage is overprinted by two intermediate-sulphidation stages, one Zn-Pb-Au rich (sphalerite-galena-electrum) and one Cu-(Au) rich (tennantite), respectively. The known mineralisation along ~800m strike length shows a distinct metal zonation from NE to SW of Cu-Au→ Cu+Zn+Pb+Ag →Ag+Pb →Ag. This metal zonation is mainly linked to the mineralogy of the initial high- sulphidation ore stage. Ar-Ar dating of alunite from the Mt Carlton lithocap gives an age of 284.3 ± 2.0 Ma. It is not distinguishable from U-Pb ages of the Lizzie Creek volcanic rocks (283-287 ± 2-4 Ma), indicating that the mineralisation occurred shortly after the formation of the host rocks. Stable isotope analyses (S, O, H) of sulfates (alunite, anhydrite and barite) and coeval pyrite suggest that they formed from a SO42- -dominated fluid with a mixed magmatic-meteoric signature. Thermometric calculations based on S isotope pairs indicate a temperature range of ~220-130 °C for the hydrothermal alteration stage (alunite-pyrite), and ~130-115 °C for late, intermediate-sulphidation ore (sphalerite-galena, sphalerite-pyrite). The combined petrographic and isotopic evidence thus suggest that a cooling fluid that evolved from high - to intermediate-sulphidation states was involved in the genesis of the Mt Carlton deposit