Anti-N-methyl-d-aspartate receptor encephalitis triggered by emotional stress

© 2019, Copyright © 2019 Baylor University Medical Center. A 22-year-old woman presented with disorganized behaviors, restlessness, and subacute decline in mental status in the setting of stress. Extensive workup for autoimmune diseases disclosed positive anti-N-methyl-d-aspartate (NMDA) receptor antibodies. We recommend that fertility preservation should be discussed and stress management should be considered in patients with a history of anti-NMDA autoimmune encephalitis because this can help in preventing relapse

Centaur 1947

Digitised by the Faculty of the Veterinary Scienc

Microbial Analysis and Sensory Attributes of Garri Produced and Marketed in Bida Niger State, Nigeria

Garri is one of the most preferred cassava products due to its less expensive nature, less bulky, easy to cook and not readily perishable. This study was carried out to ascertain the microbial analysis and sensory attributes of garri produced and marketed in Bida Niger state, Nigeria. The collected samples were analyzed using standard methods and procedures. The results show moisture content of the garri sample ranged from 7.0 to 11.0%. The swelling index ranged from 2.0 to 4.0%.  The mean bacteria count ranged from 4.04±3.98 to 4.11±3.98 Cfu/g and the mean fungal count ranged from 3.57±3.50 to 3.62±3.50 Cfu/g. There was no significant difference (p>0.05) in the mean bacterial and fungal count observed among the samples from the studied garri production area. The bacterial isolates encountered were Micrococcus sp., Streptococcus sp., Bacillus sp., Staphylococcus aureus and Shigella sp. While the fungal isolates were Aspergillus flavus, Aspergillus niger, Cladosporium sp., Rhizopus sp., Penicillium sp. and Fusarium sp. Most of the isolates are of public health importance and there is need to maintain a clean, safe personal and environmental hygiene in garri producing areas of Bida Niger state to avoid microbial contamination

Plasminogen activator‐1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non‐vitronectin‐dependent mechanism

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108289/1/jth12644.pd

Knowledge, perception and willingness to receive the current COVID-19 vaccine among residents of Awka metropolis, Anambra State, Nigeria

Background: Vaccines can effectively reduce most morbidities and mortalities caused by infectious agents. The emergence of the COVID-19 vaccine may be accompanied with huge success in containing the pandemic. The aim of the study was to assesses knowledge, perception and willingness to receive the current COVID-19 vaccine among residents in Awka metropolis, Anambra State, Nigeria.Methods: Using a pre-tested semi-structured questionnaire, this study was conducted in Awka metropolis Anambra State, Nigeria among 393 respondents (aged 18 years and above), and analyzed to assess their knowledge, perception and willingness to receive the current COVID-19 vaccine. Statistical package for social sciences software (SPSS) version 23.0 was used, descriptive statistics were reported in frequencies and percentages, Chi-square test was used to assess the association between socio-demographic characteristics and willingness to receive the vaccine, and level of significance was set at p<0.05.Results: The results showed that all respondents (100%) have good knowledge of the vaccine availability. Only 25.7% were willing to receive the vaccine, although 57.3% were willing to receive any other vaccine apart from the COVID-19 vaccine. Very few respondents (18.3%) thinks the vaccine is accessible to all. Most of the respondents (72%) did not support mandatory implementation of COVID-19 vaccine in Nigeria. Among the socio-demographic characteristics, only occupation was significantly associated with willingness to receive the vaccine (p=0.010, χ2=20.214).  Conclusions: This study highlighted the need to effectively educate the masses through appropriate public health literacy programs and enlightenment campaigns on the role of the vaccine in curbing this pandemic

Josephson effect in double-barrier superconductor-ferromagnet junctions

We study the Josephson effect in ballistic double-barrier SIFIS planar junctions, consisting of bulk superconductors (S), a clean metallic ferromagnet (F), and insulating interfaces (I). We solve the scattering problem based on the Bogoliubov--de Gennes equations and derive a general expression for the dc Josephson current, valid for arbitrary interfacial transparency and Fermi wave vectors mismatch (FWVM). We consider the coherent regime in which quasiparticle transmission resonances contribute significantly to the Andreev process. The Josephson current is calculated for various parameters of the junction, and the influence of both interfacial transparency and FWVM is analyzed. For thin layers of strong ferromagnet and finite interfacial transparency, we find that coherent (geometrical) oscillations of the maximum Josephson current are superimposed on the oscillations related to the crossover between 0 and $\pi$ states. For the same case we find that the temperature-induced $0-\pi$ transition occurs if the junction is very close to the crossovers at zero temperature.Comment: 13 pages, 6 figure

Body Mass Index, Blood Pressure and Serum Cortisol Level as Stress Index in Symptomatic HIV/AIDS Male Subjects on Antiretroviral Therapy Negative to Malaria Parasite in Nnewi, Anambra State, Nigeria

Background: HIV infection is a risk factor for a variety of endocrine problems. Objectives: This study investigated the body mass index (BMI), Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and serum cortisol level as stress factor/index symptomatic HIV/AIDS male subjects on ART who are negative to malaria parasite in Nnewi, Anambra State, Nigeria. Methods: A total of 274 adult male participants aged between 18 and 60 (42 ±13) years were randomly recruited at the Voluntary Counseling and Testing (VCT) Centre in Nnamdi Azikiwe University Teaching Hospital and grouped based on WHO criteria for staging HIV into symptomatic HIV (stage 11) infected male participants on ART (A: n=69), Symptomatic HIV subjects not on ART (B: n= 69), Asymptomatic HIV positive subjects (C: n= 68) and HIV seronegative subjects (D: n= 68). Blood samples were collected from the participants for the determination of HIV status by immunochromatography and HIV confirmation by Western Blot. Enzyme-Linked Immunosorbent Assay (ELISA) was used to assay for cortisol level. Results: The results showed a significantly increased BMI and decreased mean serum cortisol level in HIV/AIDS seropositive participants on ART than in those, not on ART (p&lt;0.05). Also, the BMI and mean serum cortisol level were significantly decreased and increased respectively in&nbsp; HIV/AIDS seropositive participants not on ART than in Asymptomatic HIV positive subjects and control respectively (p&lt;0.05). However, the mean SBP and DBP did not differ significantly between the groups studied (p&gt;0.05). Conclusion: This study revealed a decreased stress index in HIV/AIDS subjects on ART with hypercortisolism and lower BMI in symptomatic HIV participants, not on ART. Keywords: HIV; AIDS; Malaria uninfected male subjects; Cortisol; Blood pressure; Antiretroviral therapy

Body Mass Index, Blood Pressure and Serum Cortisol Level as Stress Index in Symptomatic HIV/AIDS Male Subjects on Antiretroviral Therapy Negative to Malaria Parasite in Nnewi, Anambra State, Nigeria

Background: HIV infection is a risk factor for a variety of endocrine problems. Objectives: This study investigated the body mass index (BMI), Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and serum cortisol level as stress factor/index symptomatic HIV/AIDS male subjects on ART who are negative to malaria parasite in Nnewi, Anambra State, Nigeria. Methods: A total of 274 adult male participants aged between 18 and 60 (42 ±13) years were randomly recruited at the Voluntary Counseling and Testing (VCT) Centre in Nnamdi Azikiwe University Teaching Hospital and grouped based on WHO criteria for staging HIV into symptomatic HIV (stage 11) infected male participants on ART (A: n=69), Symptomatic HIV subjects not on ART (B: n= 69), Asymptomatic HIV positive subjects (C: n= 68) and HIV seronegative subjects (D: n= 68). Blood samples were collected from the participants for the determination of HIV status by immunochromatography and HIV confirmation by Western Blot. Enzyme-Linked Immunosorbent Assay (ELISA) was used to assay for cortisol level. Results: The results showed a significantly increased BMI and decreased mean serum cortisol level in HIV/AIDS seropositive participants on ART than in those, not on ART (p&lt;0.05). Also, the BMI and mean serum cortisol level were significantly decreased and increased respectively in&nbsp; HIV/AIDS seropositive participants not on ART than in Asymptomatic HIV positive subjects and control respectively (p&lt;0.05). However, the mean SBP and DBP did not differ significantly between the groups studied (p&gt;0.05). Conclusion: This study revealed a decreased stress index in HIV/AIDS subjects on ART with hypercortisolism and lower BMI in symptomatic HIV participants, not on ART. Keywords: HIV; AIDS; Malaria uninfected male subjects; Cortisol; Blood pressure; Antiretroviral therapy

Effect of coffee consumption on liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase), total and conjugated bilirubin levels among students in Nnewi

Background: Coffee has a number of bioactive compounds that have beneficial effects on human health in general and more importantly is the fact that coffee consumption has positive impact on the liver function. The present study investigated the effect of coffee consumption on liver enzymes: alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), total bilirubin (TB) and conjugated bilirubin (CB) levels among student in Nnewi.Methods: A total of twenty-five (25) apparently healthy participants aged between 18 and 30 years which were randomly recruited from College of Health Sciences’ students to serve as both test and control group. Each participant was advised to abstain from coffee and similar beverages for a period of three weeks prior to the commencement of the study. Subsequently, in addition to their normal diet, each of the subjects was given 2 gm of coffee dissolved in 150 ml of hot water in which 50 mg of non-dairy creamer was added before breakfast daily for 28 consecutive days. 6 ml each of baseline and test samples (after an overnight fast) were collected at day 0 and 29 respectively from each participant. Liver enzymes such as ALT, AST, and ALP activity as well as TB and CB levels was determined using standard laboratory methods.Results: This showed significant reductions in the mean serum AST and ALT activity, TB and unconjugated bilirubin (UB) levels with no significant alterations in the mean ALP activity and CB level in participants studied after short-term coffee consumption.Conclusions: This study revealed the hepatoprotective effect of coffee intake at short term basis