Contested staring: issues and the use of mutual gaze as an on-line measure of social presence

Despite many of the current social presence measures relying heavily on subjective post-test questionnaires, some researchers have identified the value of using on-line, behavioural measures. Gaze, and specifically mutual gaze, is known to be related to social perceptions of an interlocutor, as well as facilitating task performance during an interaction [1, 2, 17]. Second Life allows for the investigation of task- based interaction in a highly controllable social environment, whilst simultaneously allowing measurement of eye movements (using a head-mounted eye-tracker). A paradigm for measuring eye movements of a user during interaction with an avatar or agent is presented. The potential for using this paradigm to investigate the use of mutual gaze as an on- line measure of social presence is discussed

Building Responsive Library Collections with the Getting It System Toolkit

The Getting It System Toolkit (GIST), a suite of free and open source tools & software, leverages systems to optimize library acquisitions and deselection workflow, reducing the staff time necessary to make informed decisions and process materials. The Toolkit is divided into two functions:GIST for ILLiad consists of three components that enhance the ILLiad® interlibrary loan request management software: addons, webpage customizations, and the acquisitions manager. All three components may be selectively utilized in ILLiad, for instance, ILLiad web pages may be applied to enhance the end-user request interface to add full-text discovery, or an ILLiad Addon can help ILL’s purchase on demand program discover the best way to purchase items difficult to borrow. By combining all three and customizing these components for your library, you achieve significant benefits and optimize the combination of Acquisitions and ILL services.The GIST Gift & Deselection Manager (GDM) is designed to manage and streamline library workflow for processing gifts and evaluating materials for weeding. It is standalone open-source software that automates the gathering of data for evaluating donations; including holdings, edition comparisons, full-text, and other data. The GDM also enables collection managers to perform item-by-item deselection or use the batch analysis tool to create custom deselection reports for large weeding projects.Building Responsive Library Collections with the Getting It System Toolkit combines helpful how-tos from the developers themselves, and first-hand implementation accounts from users of these time-saving tools. The volume is split into the Toolkit’s use with ILLiad and GDM, providing easy reference for users. This manual is an invaluable resource to any library using, or considering using, the Getting It System Toolkit. With contributions by: Kerri Goergen-Doll, Oregon State University Eric Joslin, Washington University in St. Louis Ryan Litsey, Texas Tech University Micquel Little, Monroe Community College, formerly at St. John Fisher College Katherine Mason, Central Michigan University, formerly at Old Dominion University Kate Ross, St. John Fisher College Susanna Van Sant, Tompkins Cortland Community Collegehttps://knightscholar.geneseo.edu/idsproject-press/1001/thumbnail.jp

Don't look now:The relationship between mutual gaze, task performance and staring in Second Life

Mutual gaze is important to social interaction, and can also\ud facilitate task performance. Previous work has assumed that staring\ud at someone maximises mutual gaze. Eye-tracking is used to\ud explore this claim, along with the relationship between mutual\ud gaze and task performance. Two participants – Instruction Giver\ud (IG) and Instruction Follower (IF) – communicated via avatars in\ud Second Life to solve simple arithmetic tasks. There were two\ud conditions: staring (the IG‟s avatar stared continuously at the IF);\ud and not-staring, (IG‟s avatar looked at IF and task-relevant\ud objects). Instead of maximising mutual gaze, constant staring\ud actually showed evidence of decreasing eye contact within the\ud dyad. Mutual gaze was positively correlated with task performance\ud scores, but only in the not-staring condition. When not engaged in\ud mutual gaze, the IF looked more at task-related objects in the notstaring\ud condition than in the staring condition. Implications and\ud possible future work on social interaction are discussed

Contested Staring: Issues and the use of mutual gaze as an on-line measure of social presence

Despite many of the current social presence measures relying heavily on subjective post-test questionnaires, some researchers have identified the value of using on-line, behavioural measures. Gaze, and specifically mutual gaze, is known to be related to social perceptions of an interlocutor, as well as facilitating task performance during an interaction [1, 2, 17]. Second Life allows for the investigation of task- based interaction in a highly controllable social environment, whilst simultaneously allowing measurement of eye movements (using a head-mounted eye-tracker). A paradigm for measuring eye movements of a user during interaction with an avatar or agent is presented. The potential for using this paradigm to investigate the use of mutual gaze as an on- line measure of social presence is discussed

Don't Look Now: The relationship between mutual gaze, task performance and staring in Second Life

Mutual gaze is important to social interaction, and can also facilitate task performance. Previous work has assumed that staring at someone maximises mutual gaze. Eye-tracking is used to explore this claim, along with the relationship between mutual gaze and task performance. Two participants – Instruction Giver (IG) and Instruction Follower (IF) – communicated via avatars in Second Life to solve simple arithmetic tasks. There were two conditions: staring (the IG‟s avatar stared continuously at the IF); and not-staring, (IG‟s avatar looked at IF and task-relevant objects). Instead of maximising mutual gaze, constant staring actually showed evidence of decreasing eye contact within the dyad. Mutual gaze was positively correlated with task performance scores, but only in the not-staring condition. When not engaged in mutual gaze, the IF looked more at task-related objects in the notstaring condition than in the staring condition. Implications and possible future work on social interaction are discussed

Antidepressant exposure in pregnancy and child sensorimotor and visuospatial development

Motor development underlies many aspects of education and learning. There has been uncertainty about the impact of exposure of antidepressant medication in pregnancy on child motor outcomes. This paper examines whether exposure to antidepressants in utero increases the risk of poorer motor development in two areas: sensorimotor and visuospatial processing. Data were obtained from 195 women and children across 3 groups: women with untreated depression in pregnancy, women treated with antidepressants and control women. Data were collected across pregnancy, postpartum and until 4 years for mother and child. Maternal depression was established at baseline with the Structured Clinical Interview for DSM-IV. Antidepressant exposure, including type, dose and timing, was measured through repeated self-report across pregnancy and the postpartum, medical records at delivery and in cord blood samples collected at delivery. Child sensorimotor and visuospatial outcomes were assessed at 4 years of age with four subtests from the NEPSY-II. Our study found for sensorimotor development, visuomotor precision completion time was associated with better performance for antidepressant exposed children compared to those with mothers with untreated depression. Yet another measure of sensorimotor development, motor manual sequences, was poorer in those exposed to antidepressants. One subtest for visuospatial processing, block construction, was associated with poorer performance in antidepressant-exposed children who had poor neonatal adaptation and those exposed to a higher dose of antidepressant. These findings suggest an inconsistent association between sensorimotor development and antidepressant use in pregnancy. However, the findings for visuospatial processing would support further exploration of antidepressant associated poor neonatal adaption and later motor development

Risk factors for hospitalizations associated with depression among women during the years around a birth: a retrospective cohort study

Introduction Socio-economic status (SES) is an important determinant of health and low SES is associated with higher rates of prenatal and post-partum depression while prenatal and post-partum depression are associated with sub-optimal maternal and infant health. Furthermore, increased negative effects of post-partum depression have been reported in children from low SES backgrounds. Objectives To assess whether socio-economic status (SES) was related to the risk of a medical or psychiatric hospitalization associated with depression (HAWD) and the risk of a HAWD by anti-depressant (AD) use during the years around a birth Methods This retrospective cohort study used linked birth, hospitalization, prescription and tax-file records of the study cohort. We linked registry data of 243,933 women delivering 348,273 live infants in British Columbia (1999-2009). The outcomes of interest were a HAWD and a HAWD and the associated patient anti-depressant (AD) use. Ranked area-based measures of equivalised, family disposable income were used to create income deciles (Decile-1 low), our proxy for SES. Mothers from Decile-6 were the comparator group. Anti-depressant use was defined as having a prenatal prescription for a serotonin reuptake inhibitor or other AD and the years around a birth were the period beginning 12 months before conception and ending 12 months after the birth. We analysed by pregnancy using mixed effects logistic regression whilst adjusting for maternal age and parity. Results                                                                                    Compared to middle-income mothers from Decile-6, (Decile-1, Decile-2) mothers from low income neighbourhoods had increased odds of HAWDs [aOR=1.77(CI: 1.43, 2.19); aOR=1.56(CI: 1.26, 1.94)]. Mothers from low income areas with depression and no AD use had even higher odds of HAWDs [aOR=1.83(CI: 1.33, 2.20); aOR=1.71(CI: 1.33, 2.20)]. Conclusions Results provide preliminary evidence that barriers to treating depression with ADs in mothers from low income areas during the years around a birth might contribute to their increased risk of a hospitalization associated with non-pharmacologically treated depression. Further research is implicated to further elucidate the origins of this increased risk

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates

Some but not all neonates are affected by prenatal exposure to serotonin reuptake inhibitor antidepressants (SRI) and maternal mood disturbances. Distinguishing the impact of these 2 exposures is challenging and raises critical questions about whether pharmacological, genetic, or epigenetic factors can explain the spectrum of reported outcomes. Using unbiased DNA methylation array measurements followed by a detailed candidate gene approach, we examined whether prenatal SRI exposure was associated with neonatal DNA methylation changes and whether such changes were associated with differences in birth outcomes. Prenatal SRI exposure was first associated with increased DNA methylation status primarily at CYP2E1(βNon-exposed = 0.06, βSRI-exposed = 0.30, FDR = 0); however, this finding could not be distinguished from the potential impact of prenatal maternal depressed mood. Then, using pyrosequencing of CYP2E1 regulatory regions in an expanded cohort, higher DNA methylation status both the mean across 16 CpG sites (P < 0.01) and at each specific CpG site (P < 0.05) was associated with exposure to lower 3rd trimester maternal depressed mood symptoms only in the SRI-exposed neonates, indicating a maternal mood x SRI exposure interaction. In addition, higher DNA methylation levels at CpG2 (P = 0.04), CpG9 (P = 0.04) and CpG10 (P = 0.02), in the interrogated CYP2E1 region, were associated with increased birth weight independently of prenatal maternal mood, SRI drug exposure, or gestational age at birth. Prenatal SRI antidepressant exposure and maternal depressed mood were associated with altered neonatal CYP2E1 DNA methylation status, which, in turn, appeared to be associated with birth weight

Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome

Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized to result in part from dysregulated sympathetic function. A candidate gene analysis of COMT rs4680 effects on clinical outcomes in the Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial (NorCAPITAL), a randomized double-blinded clonidine versus placebo trial, was conducted (N=104). Patients homozygous for rs4680 high-activity allele randomized to clonidine took 2,500 fewer steps compared to placebo (pinteraction=0.04). There were no differences between clonidine and placebo amongst patients with COMT low-activity alleles. Similar gene-drug interactions were observed for sleep (pint=0.003) and quality of life (pint=0.018). Detrimental effects of clonidine in the subset of CFS patients homozygous for COMT high-activity allele warrant investigation of potential clonidine-COMT interaction effects in other conditions