Conjunction study of plasmapause location using ground‐based magnetometers, IMAGE‐EUV, and Kaguya‐TEX data

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94992/1/jgra20214.pd

Uncovering Algebraic Structures in the MPC Landscape

A fundamental problem in the theory of secure multi-party computation (MPC) is to characterize functions with more than 2 parties which admit MPC protocols with information-theoretic security against passive corruption. This question has seen little progress since the work of Chor and Ishai (1996), which demonstrated difficulties in resolving it. In this work, we make significant progress towards resolving this question in the important case of aggregating functionalities, in which m parties P1, . . . , Pm hold inputs x1, . . . , xm and an aggregating party P0 must learn f(x1,...,xm). We uncover a rich class of algebraic structures that are closely related to secure computability, namely, “Commuting Permutations Systems” (CPS) and its variants. We present an extensive set of results relating these algebraic structures among themselves and to MPC, including new protocols, impossibility results and separations. Our results include a necessary algebraic condition and slightly stronger sufficient algebraic condition for a function to admit information-theoretically secure MPC protocols. We also introduce and study new models of minimally interactive MPC (called UNIMPC and UNIMPC*), which not only help in understanding our positive and negative results better, but also open up new avenues for studying the cryptographic complexity landscape of multi-party functionalities. Our positive results include novel protocols in these models, which may be of independent practical interest. Finally, we extend our results to a definition that requires UC security as well as semi-honest security (which we term strong security). In this model we are able to carry out the characterization of all computable functions, except for a gap in the case of aggregating functionalities

Three‐dimensional P wave velocity structure of the Northern Hikurangi margin from the NZ3D experiment: evidence for fault‐bound anisotropy

We present a high‐resolution three‐dimensional (3‐D) anisotropic P wave velocity (Vp) model in the northern Hikurangi margin offshore Gisborne, New Zealand, constructed by tomographic inversion of over 430,000 first arrivals recorded by a dense grid of ocean bottom seismometers. Since the study area covers a region where shallow slow slip events (SSEs) occur repeatedly and the subduction of a seamount is proposed, it offers an ideal location to link our understanding of structural and hydrogeologic properties at megathrust faults to slip behavior. The Vp model reveals an ~30‐km‐wide, low‐velocity accretionary wedge at the toe of the overriding plate, where previous seismic reflection studies show a series of active thrust faults branching from the plate interface. We find some locations with significant Vp azimuthal anisotropy >5% near the branching faults and the deformation front. This finding suggests that the anisotropy is not ubiquitous and homogeneous within the overriding plate, but more localized in the vicinity of active thrust faults. The fast axes of Vp within the accretionary wedge are mostly oriented to the plate convergence direction, which is interpreted as preferentially oriented cracks in a compressional stress regime associated with plate subduction. We find that the magnitudes of anisotropy are roughly equivalent to values found at oceanic spreading centers, where the extensional stress regime is dominant and the crack density is expected to be higher than subduction zones. This consideration may indicate that additional effects such as fault foliation and clay mineral alignment also contribute to upper plate anisotropy along subduction margins

Long-lasting geomagnetically induced currents and harmonic distortion observed in New Zealand during the 07-08 September 2017 Disturbed Period

Several periods of Geomagnetically Induced Currents (GIC) were detected in the Halfway Bush substation in Dunedin, South Island, New Zealand, as a result of intense geomagnetic storm activity during 06 to 09 September 2017. Unprecedented data coverage from a unique combination of instrumentation is analyzed, i.e., measurements of GIC on the single phase bank transformer T4 located within the substation, nearby magnetic field perturbation measurements, very low frequency (VLF) wideband measurements detecting the presence of power system harmonics, and high‐voltage harmonic distortion measurements. Two solar wind shocks occurred within 25 hours, generating four distinct periods of GIC. Two of the GIC events were associated with the arrival of the shocks themselves. These generated large but short‐lived GIC effects that resulted in no observable harmonic generation. Nearby and more distant magnetometers showed good agreement in measuring these global‐scale magnetic field perturbations. However, two subsequent longer‐lasting GIC periods, up to 30 minutes in duration, generated harmonics detected by the VLF receiver systems, when GIC levels continuously exceeded 15 A in T4. Nearby and more distant magnetometers showed differences in their measurements of the magnetic field perturbations at these times, suggesting the influence of small‐scale ionospheric current structures close to Dunedin. VLF receiver systems picked up harmonics from the substation, up to the 30th harmonic, consistent with observed high‐voltage increases in even harmonic distortion, along with small decreases in odd harmonic distortion

A protein kinase Cβ inhibitor attenuates multidrug resistance of neuroblastoma cells

BACKGROUND: The acquisition of drug resistance is a major reason for poor outcome of neuroblastoma. Protein kinase C (PKC) has been suggested to influence drug resistance in cancer cells. The aim of this study was to elucidate whether inhibition of PKCβ isoforms influences drug-resistance of neuroblastoma cells. METHODS: The effect of the PKCβ inhibitor LY379196 on the growth-suppressing effects of different chemotherapeutics on neuroblastoma cells was analyzed with MTT assays. The effect of LY379196 on the accumulation of [(3)H]vincristine was also investigated RESULTS: The PKCβ inhibitor LY379196 suppressed the growth of three neuroblastoma cell lines. LY379196 also augmented the growth-suppressive effect of doxorubicin, etoposide, paclitaxel, and vincristine, but not of carboplatin. The effect was most marked for vincristine and for the cell-line (SK-N-BE(2)) that was least sensitive to vincristine. No effect was observed on the non-resistant IMR-32 cells. Two other PKC inhibitors, Gö6976 and GF109203X, also enhanced the vincristine effect. The PKC inhibitors caused an increased accumulation of [(3)H]vincristine in SK-N-BE(2) cells. CONCLUSIONS: This indicates that inhibition of PKCβ could attenuate multidrug resistance in neuroblastoma cells by augmenting the levels of natural product anticancer drugs in resistant cells

Low Dose Organochlorine Pesticides and Polychlorinated Biphenyls Predict Obesity, Dyslipidemia, and Insulin Resistance among People Free of Diabetes

There is emerging evidence that background exposure to persistent organic pollutants (POPs) are important in the development of conditions predisposing to diabetes as well as of type 2 diabetes itself. We recently reported that low dose POPs predicted incident type 2 diabetes in a nested case-control study. The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study.The 90 controls were diabetes-free during 20 years follow-up. They were a stratified random sample, enriched with overweight and obese persons. POPs measured in 1987-88 (year 2) sera included 8 organochlorine (OC) pesticides, 22 polychlorinated biphenyls (PCBs), and 1 polybrominated biphenyl (PBB). Body mass index (BMI), triglycerides, HDL-cholesterol, LDL-cholesterol, and homeostasis model assessment value for insulin resistance (HOMA-IR) were study outcomes at 2005-06 (year 20). The evolution of study outcomes during 18 years by categories of serum concentrations of POPs at year 2 was evaluated by adjusting for the baseline values of outcomes plus potential confounders. Parallel to prediction of type 2 diabetes, many statistically significant associations of POPs with dysmetabolic conditions appeared at low dose, forming inverted U-shaped dose-response relations. Among OC pesticides, p,p'-DDE most consistently predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 after adjusting for baseline values. Oxychlordane, trans-nonachlor, and hexachlorobenzene also significantly predicted higher triglycerides. Persistent PCBs with ≥7 chlorides predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 with similar dose-response curves.Simultaneous exposure to various POPs in the general population may contribute to development of obesity, dyslipidemia, and insulin resistance, common precursors of type 2 diabetes and cardiovascular diseases. Although obesity is a primary cause of these metabolic abnormalities, POPs exposure may contribute to excess adiposity and other features of dysmetabolism