The line

The Line is a series of exaggerated contemporary jewelry “products” that engage the audience through collecting, marketing, and nostalgia. It grew from a dissatisfaction with the world of “contemporary jewelry,” or “art jewelry,” or “author jewelry,” or whatever people are calling the field now (assuming they’re calling it anything). The Line pushes against the rarely questioned conventions of contemporary jewelry by playing along with them (sometimes even playing a little rough). This work intentionally walks on the lines between jewelry and art, and between art and product: lines that exist whether we want them to or not, but which can and should be blurred if contemporary jewelry is to break out of the liminal space it exists in now

Developing a rabies prevention program based on rabies exposure data in Nebraska

Eighty-nine percent of Nebraska’s towns are considered rural, with populations of less than 3,000 people and with many towns having less than 1,000 residents. Rural areas consist of crop ground, livestock facilities and regions inhabited by wildlife. Nebraska has two large urban cities, Lincoln and Omaha. Animal and human health in these communities can be greatly impacted by infectious diseases that are transmitted between animals and humans, known as zoonotic diseases. One zoonotic disease of great concern is rabies. Zoonotic diseases not only impact the health of animals and humans, but the social well-being of communities and result in increased costs to control and eliminate outbreaks. The risk of transmission of rabies from animal to animal and animal to human is a Public Health concern. Rabies left untreated in humans is fatal. To reduce the risk of human exposure between animals, the public needs to be made aware of the problem and prevention measures that can be taken. This project proposed to the Nebraska Department of Health and Human Services to analyze rabies data to create summary data tables that will be made publicly available. These summaries describe what type that had been collected between 2010 – 2019, and to use these data to create materials that will be used to improve community awareness regarding the extent of the rabies problem and methods of prevention

“I KNEW I WANTED MORE FOR MYSELF”: SEXUAL MINORITY MEN’S NARRATIVES ABOUT GETTING HELP FOR INTIMATE PARTNER VIOLENCE

Sexual minority men experience intimate partner violence (IPV) at rates similar to, if not higher, than heterosexual individuals (Finneran & Stephenson, 2013). IPV is associated with a range of negative health outcomes in this population, such as increased risk for depression and anxiety (Miller & Irvin, 2017) and increased sexual risk-taking and subsequent HIV acquisition (Craft & Serovich, 2005; Houston & McKirnan, 2007). Many barriers prevent sexual minority men from getting help for IPV including stigma-related stressors, socioeconomic status, HIV status, perceived lack of helping resources, and a lack of knowledge about IPV (Duke & Davidson, 2009; Edwards, Sylaska, & Neal, 2015). Little is known about how sexual minority men overcome these barriers and access the psychological support and help that they need. This study explored this process using a grounded theory methodology. Twelve sexual minority men volunteered to be individually interviewed about their experiences with seeking and getting professional psychological help for IPV in an intimate relationship. Findings revealed a process that included (1) triggering events; (2) motivation to seek help; (3) searching for help; (4) getting help and persisting with the therapeutic process. A triggering event (i.e., an incident of IPV or mental health concerns following IPV) resulted in participants searching for psychological help from psychologists, therapists, and/or psychiatrists. Personal motivators, such as character strengths, responding to important relationships, and wanting insight about their experience with IPV, led to help-seeking. Searching for help required participants to push past concerns and worries using character strengths to engage in web searches or to follow up on referrals from healthcare providers and from important people in their lives. Clinicians’ flexible scheduling, therapeutic style and presence, and personal characteristics helped men persist with help-seeking. Implications for policy and psychotherapy practice with sexual minority men are discussed. In particular, implications for clinicians working with this population are explored based on each step of this help-seeking process. Inclusive education and training needs to be provided to health service providers, mental health practitioners, and community members. Mental health providers need training to provide culturally competent services to sexual minority men who are IPV survivors and for services to be visible and widely advertised to promote help-seeking

The biology of the red-banded leaf roller, Argyrotaenia velutinana (Wlkr.), in Missouri with notes on its natural control

Portion of a dissertation submitted to the Faculty of the Graduate School, University of Missouri, Columbia, in partial fulfillment of the requirements for the degree of Master of Science in Entomology--Page [3].Includes bibliographical references (page 14).Description based on print version record.Includes bibliographical references (page 14)

Kindergarten Readiness Summer Speech Boot Camp—Can Children Make Enough Gains in Their Stimulability of Target Sounds Over Summer Break?

Children with mild-to-moderate speech sound disorder (SSD) often don’t qualify for an Individualized Education Plan (IEP) in the public-school setting as a result of the large caseloads that school-based speech-language pathologists (SLP) have. Previous studies have shown promise in intensive speech programs that target specific sounds to help children improve their overall production accuracy. This study examined the potential of a short-term, intensive program that occurred during the summer before a child began school. Four children with mild-to-moderate SSD who were planning on starting Kindergarten the following fall semester participated in the summer speech boot camp study. Results showed that this program design coupled with using the complexity approach may help children with mild-to-moderate articulation deficits rapidly improve their speech prior to starting Kindergarten. Possible modifications to the treatment based on these findings are discussed

Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona

Traumatic brain injury (TBI) in children can result in long-lasting social, cognitive, and neurological impairments. In adults, TBI can lead to endocrinopathies (endocrine system disorders), but this is infrequently reported in children. Untreated endocrinopathies can elevate risks of subsequent health issues, such that early detection in pediatric TBI survivors can initiate clinical interventions. To understand the risk of endocrinopathies following pediatric TBI, we identified patients who had experienced a TBI and subsequently developed a new-onset hypothalamic regulated endocrinopathy (n = 498). We hypothesized that pediatric patients who were diagnosed with a TBI were at higher risk of being diagnosed with a central endocrinopathy than those without a prior diagnosis of TBI. In our epidemiological assessment, we identified pediatric patients enrolled in the Arizona Health Care Cost Containment System (AHCCCS) from 2008 to 2014 who were diagnosed with one of 330 TBI International Classification of Diseases (ICD)-9 codes and subsequently diagnosed with one of 14 central endocrinopathy ICD-9 codes. Additionally, the ICD-9 code data from over 600,000 Arizona pediatric patients afforded an estimate of the incidence, prevalence, relative risk, odds ratio, and number needed to harm, regarding the development of a central endocrinopathy after sustaining a TBI in Arizona Medicaid pediatric patients. Children with a TBI diagnosis had 3.22 times the risk of a subsequent central endocrine diagnosis compared with the general population (±0.28). Pediatric AHCCCS patients with a central endocrine diagnosis had 3.2-fold higher odds of a history of a TBI diagnosis than those without an endocrine diagnosis (±0.29). Furthermore, the number of patients with a TBI diagnosis for one patient to receive a diagnosis of a central endocrine diagnosis was 151.2 (±6.12). Female subjects were more likely to present with a central endocrine diagnosis after a TBI diagnosis compared to male subjects (64.1 vs. 35.9%). These results are the first state-wide epidemiological study conducted to determine the risk of developing a hypothalamic-pituitary disorder after a TBI in the pediatric population. Our results contribute to a body of knowledge demonstrating a TBI etiology for idiopathic endocrine disorders, and thus advise physicians with regard to TBI follow-up care that includes preventive screening for endocrine disorders.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer

BACKGROUND:Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterized by an elevated mutation rate and genomic instability. If a field defect were deficient in DNA repair, DNA damages would tend to escape repair and give rise to carcinogenic mutations.PURPOSE:To determine whether reduced expression of DNA repair proteins Pms2, Ercc1 and Xpf (pairing partner of Ercc1) are early steps in progression to colon cancer.RESULTS:Tissue biopsies were taken during colonoscopies of 77 patients at 4 different risk levels for colon cancer, including 19 patients who had never had colonic neoplasia (who served as controls). In addition, 158 tissue samples were taken from tissues near or within colon cancers removed by resection and 16 tissue samples were taken near tubulovillous adenomas (TVAs) removed by resection. 568 triplicate tissue sections (a total of 1,704 tissue sections) from these tissue samples were evaluated by immunohistochemistry for 4 DNA repair proteins. Substantially reduced protein expression of Pms2, Ercc1 and Xpf occurred in field defects of up to 10 cm longitudinally distant from colon cancers or TVAs and within colon cancers. Expression of another DNA repair protein, Ku86, was infrequently reduced in these areas. When Pms2, Ercc1 or Xpf were reduced in protein expression, then either one or both of the other two proteins most often had reduced protein expression as well. The mean inner colon circumferences, from 32 resections, of the ascending, transverse and descending/sigmoid areas were measured as 6.6 cm, 5.8 cm and 6.3 cm, respectively. When combined with other measurements in the literature, this indicates the approximate mean number of colonic crypts in humans is 10 million.CONCLUSIONS:The substantial deficiencies in protein expression of DNA repair proteins Pms2, Ercc1 and Xpf in about 1 million crypts near cancers and TVAs suggests that the tumors arose in field defects that were deficient in DNA repair and that deficiencies in Pms2, Ercc1 and Xpf are early steps, often occurring together, in progression to colon cancer.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]

Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression

Translational control of transcription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While it is typically induced by phosphorylation of eIF2α, ATF4 translation can be also induced by expression of a translational inhibitor protein, eIF5-mimic protein 1 (5MP1, also known as BZW2) in mammals. Here we show that the 5MP gene is maintained in eukaryotes under strong purifying selection, but is uniquely missing in two major phyla, nematoda and ascomycota. The common function of 5MP from protozoa, plants, fungi and insects is to control translation by inhibiting eIF2. The affinity of human 5MP1 to eIF2β was measured as being equivalent to the published value of human eIF5 to eIF2β, in agreement with effective competition of 5MP with eIF5 for the main substrate, eIF2. In the red flour beetle, Tribolium castaneum, RNA interference studies indicate that 5MP facilitates expression of GADD34, a downstream target of ATF4. Furthermore, both 5MP and ATF4 are essential for larval development. Finally, 5MP and the paired uORFs allowing ATF4 control are conserved in the entire metazoa except nematoda. Based on these findings, we discuss the phylogenetic and functional linkage between ATF4 regulation and 5MP expression in this group of eukaryotes