A framework for producing gbXML building geometry from Point Clouds for accurate and efficient Building Energy Modelling

The industrial sector accounts for 17% of end-use energy in the United Kingdom, and 54% globally. Therefore, there is substantial scope to accurately simulate and efficiently assess potential energy retrofit options for industrial buildings to lower end use energy. Due to potentially years of facility renovation and expansion Building Energy Modelling, also called Building Energy Simulation, applied to industrial buildings poses a complex challenge; but it is an important opportunity for reducing global energy demand especially considering the increase of readily available computational power compared with a few years ago. Large and complex industrial buildings make modelling existing geometry for Building Energy Modelling difficult and time consuming which impacts analysis workflow and assessment options available within reasonable budgets. This research presents a potential framework for quickly capturing and processing as-built geometry of a factory, or other large scale buildings, to be utilised in Building Energy Modelling by storing the geometry in a green building eXtensible Mark-up Language (gbXML) format, which is compatible with most commercially available Building Energy Modelling tools. Laser scans were captured from the interior of an industrial facility to produce a Point Cloud. The existing capabilities of a Point Cloud processing software and previous research were assessed to identify the potential development opportunities to automate the conversion of Point Clouds to building geometry for Building Energy Modelling applications. This led to the novel identification of a framework for storing the building geometry in the gbXML format and plans for verification of a future Point Cloud processing solution. This resulted in a sample Point Cloud, of a portion of a building, being converted into a gbXML model that met the validation requirements of the gbXML definition schema. In conclusion, an opportunity exists for increasing the speed of 3D geometry creation of existing industrial buildings for application in BEM and subsequent thermal simulation

Geometry Extraction for High Resolution Building Energy Modelling Applications from Point Cloud Data: A Case Study of a Factory Facility

The industrial sector accounts for 17% of end-use energy in the UK, and 54% globally. Therefore, there is substantial scope for simulating and assessing potential energy retrofit options for industrial buildings. Building Energy Modelling (BEM) applied to industrial buildings p oses a complex but important opportunity for reducing global energy demand, due to years of renovation and expansion. Large and complex industrial buildings make modelling existing geometry for BEM difficult and time consuming. This paper presents a potential solution for quickly capturing and processing as-built geometry of a factory to be utilized in BEM. Laser scans were captured from the interior of an industrial facility to produce a Point Cloud. The existing capabilities of a Point Cloud processing software were assessed to identify the potential development opportunities to automate the conversion of Point Clouds to building geometry for BEM applications. In conclusion, scope exists for increasing the speed of 3D geometry creation of an existing industrial building for application in BEM and subsequent thermal simulation

A review of energy simulation tools for the manufacturing sector

Manufacturing is a competitive global market and efforts to mitigate climate change are at the forefront of public perception. Current trends in manufacturing aim to reduce costs and increase sustainability without negatively affecting the yield of finished products, thus maintaining or improving profits. Effective use of energy within a manufacturing environment can help in this regard by lowering overhead costs. Significant benefit can be gained by utilising simulations in order to predict energy demand allowing companies to make effective retrofit decisions based on energy as well as other metrics such as resource use, throughput and overhead costs. Traditionally, Building Energy Modelling (BEM) and Manufacturing Process Simulation (MPS) have been used extensively in their respective fields but they remain separate and segregated which limits the simulation window used to identify energy improvements. This review details modelling approaches and the simulation tools that have been used, or are available, in an attempt to combine BEM and MPS, or elements from each, into a holistic approach. Such an approach would be able to simulate the interdependencies of multiple layers contained within a factory from production machines, process lines and Technical Building Services (TBS) to the building shell. Thus achieving a greater perspective for identifying energy improvement measures across the entire operating spectrum and multiple, if not all, manufacturing industries. In doing so the challenges associated with incorporating BEM in manufacturing simulation are highlighted as well as gaps within the research for exploitation through future research. This paper identified requirements for the development of a holistic energy simulation tool for use in a manufacturing facility, that is capable of simulating interdependencies between different building layers and systems, and a rapid method of 3D building geometry generation from site data or existing BIM in an appropriate format for energy simulations of existing factory buildings

Introme accurately predicts the impact of coding and noncoding variants on gene splicing, with clinical applications

Predicting the impact of coding and noncoding variants on splicing is challenging, particularly in non-canonical splice sites, leading to missed diagnoses in patients. Existing splice prediction tools are complementary but knowing which to use for each splicing context remains difficult. Here, we describe Introme, which uses machine learning to integrate predictions from several splice detection tools, additional splicing rules, and gene architecture features to comprehensively evaluate the likelihood of a variant impacting splicing. Through extensive benchmarking across 21,000 splice-altering variants, Introme outperformed all tools (auPRC: 0.98) for the detection of clinically significant splice variants. Introme is available at https://github.com/CCICB/introme .Patricia J. Sullivan, Velimir Gayevskiy, Ryan L. Davis, Marie Wong, Chelsea Mayoh, Amali Mallawaarachchi, Yvonne Hort, Mark J. McCabe, Sarah Beecroft, Matilda R. Jackson, Peer Arts, Andrew Dubowsky, Nigel Laing, Marcel E. Dinger, Hamish S. Scott, Emily Oates, Mark Pinese, and Mark J. Cowle

Effect of pH and soybean cultivars on the quantitative analyses of soybean rhizobia populations

Microbial Biotechnolog

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume

The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes

Heavy element production in a compact object merger observed by JWST

The mergers of binary compact objects such as neutron stars and black holes are of central interest to several areas of astrophysics, including as the progenitors of gamma-ray bursts (GRBs)1, sources of high-frequency gravitational waves (GW)2 and likely production sites for heavy element nucleosynthesis via rapid neutron capture (the r-process)3. Here we present observations of the exceptionally bright gamma-ray burst GRB 230307A. We show that GRB 230307A belongs to the class of long-duration gamma-ray bursts associated with compact object mergers4–6, and contains a kilonova similar to AT2017gfo, associated with the gravitational-wave merger GW1708177–12. We obtained James Webb Space Telescope mid-infrared (mid-IR) imaging and spectroscopy 29 and 61 days after the burst. The spectroscopy shows an emission line at 2.15 microns which we interpret as tellurium (atomic mass A=130), and a very red source, emitting most of its light in the mid-IR due to the production of lanthanides. These observations demonstrate that nucleosynthesis in GRBs can create r-process elements across a broad atomic mass range and play a central role in heavy element nucleosynthesis across the Universe