Slip inversion along inner fore-arc faults, eastern Tohoku, Japan

The kinematics of deformation in the overriding plate of convergent margins may vary across timescales ranging from a single seismic cycle to many millions of years. In Northeast Japan, a network of active faults has accommodated contraction across the arc since the Pliocene, but several faults located along the inner fore arc experienced extensional aftershocks following the 2011 Tohoku-oki earthquake, opposite that predicted from the geologic record. This observation suggests that fore-arc faults may be favorable for stress triggering and slip inversion, but the geometry and deformation history of these fault systems are poorly constrained. Here we document the Neogene kinematics and subsurface geometry of three prominent fore-arc faults in Tohoku, Japan. Geologic mapping and dating of growth strata provide evidence for a 5.6–2.2 Ma initiation of Plio-Quaternary contraction along the Oritsume, Noheji, and Futaba Faults and an earlier phase of Miocene extension from 25 to 15 Ma along the Oritsume and Futaba Faults associated with the opening of the Sea of Japan. Kinematic modeling indicates that these faults have listric geometries, with ramps that dip ~40–65°W and sole into subhorizontal detachments at 6–10 km depth. These fault systems can experience both normal and thrust sense slip if they are mechanically weak relative to the surrounding crust. We suggest that the inversion history of Northeast Japan primed the fore arc with a network of weak faults mechanically and geometrically favorable for slip inversion over geologic timescales and in response to secular variations in stress state associated with the megathrust seismic cycle.Funding was provided by a grant from the National Science Foundation Tectonics Program grant EAR-0809939 to D.M.F. and E.K., Geologic Society of America Graduate Research Grants, and the P.D. Krynine Memorial Fund. The authors thank Gaku Kimura, Kyoko Tonegawa, Hiroko Watanabe, Jun Kameda, and Asuka Yamaguchi for scientific and logistical support, and Kristin Morell for comments on early versions of the manuscript. We also thank Yuzuru Yamamoto and Kohtaro Ujiie for their detailed reviews and suggestions for improvement to the manuscript. The authors acknowledge the use of the Move Software Suite granted by Midland Valley's Academic Software Initiative. Geologic, structural, stratigraphic, and chronologic data used herein are accessible in manuscript figures, and in the citations therein. Input geologic data for trishear kinematic modeling can be accessed in Table 1 and in the supporting information. (EAR-0809939 - National Science Foundation Tectonics Program grant; Geologic Society of America Graduate Research Grants; P.D. Krynine Memorial Fund

Health and cancer prevention: knowledge and beliefs of children and young people

Objective: To collect information from children and young people about their knowledge of and attitudes towards cancer and their understanding of health and health related behaviours to inform future health promotion work. Design: Questionnaire survey of 15-16 year olds, and interviews with play materials with 9-10 year old children. Setting: Six inner city, suburban, and rural schools. Subjects: 226 children aged 15-16 years and 100 aged 9-10 years. Main outcome measures: Knowledge about different types of cancer; beliefs about health; sources of information; quality of research data obtainable from young children about cancer and health. Results: Both samples knew most about lung cancer, but there was also some knowledge of breast and skin cancer and leukaemia. Smoking, together with pollution and other environmental factors, were seen as the dominant causes of cancer. Environmental factors were mentioned more often by the inner city samples. Television and the media were the most important sources of information. Young people were more worried about unemployment than about ill health. More than half the young people did not describe their health as good, and most said they did not have a healthy lifestyle. Children were able to provide detailed information about their knowledge and understanding by using drawings as well as interviews. Conclusions: Children and young people possess considerable knowledge about cancer, especially about lung cancer and smoking, and show considerable awareness of predominant health education messages. Despite this knowledge, many lead less than healthy lifestyles. Health is not seen as the most important goal in life by many young people; the circumstances in which many children and young people live are not experienced as health promoting

A guide for the preparation, presentation and evaluation of F.F.A. radio programs in Tennessee

The purpose of the study Is to develop a guide for preparing, presenting, and evaluating F.F.A. Radio Programs in Tennessee. The work of the F.F.A. is a many-pronged tool for good and useful service. Its purpose is to improve citizenship. It nurtures better agricultural practices and better agricultural leaders. Possibly even more important is its immense educational value. The educational value is not entirely a new one, but it has not been fully recognised and exploited for the good of American agriculture. Although radio is one of our important public relations means, it may and can be used to enrich our instructional program by providing opportunity for boys to learn by doing, to express themselves in writing as well as orally, and to organize their thinking around certain problems related to specific needs. One of the beneficial and educational values is to have the boys prepare the script and then to present the broadcast

Shock accelerated vortex ring

The interaction of a shock wave with a spherical density inhomogeneity leads to the development of a vortex ring through the impulsive deposition of baroclinic vorticity. The present fluid dynamics videos display this phenomenon and were experimentally investigated at the Wisconsin Shock Tube Laboratory's (WiSTL) 9.2 m, downward firing shock tube. The tube has a square internal cross-section (0.25 m x 0.25 m) with multiple fused silica windows for optical access. The spherical soap bubble is generated by means of a pneumatically retracted injector and released into free-fall 200 ms prior to initial shock acceleration. The downward moving, M = 2.07 shock wave impulsively accelerates the bubble and reflects off the tube end wall. The reflected shock wave re-accelerates the bubble (reshock), which has now developed into a vortex ring, depositing additional vorticity. In the absence of any flow disturbances, the flow behind the reflected shock wave is stationary. As a result, any observed motion of the vortex ring is due to circulation. The shocked vortex ring is imaged at 12,500 fps with planar Mie scattering.Comment: For Gallery of Fluid Motion 200

Detection of the glucocorticoid receptors in brain protein extracts by SDS-PAGE

Uncorrected proofGlucocorticoids are steroid hormones vital for organ system homeostasis and for the maintenance of essential biological processes. A significant part of these actions are mediated through glucocorticoid receptor (GR) that belongs to the nuclear receptor superfamily. To cover such variety of processes the different glucocorticoids act through different GR isoforms that are originated due to posttranscriptional and posttranslational mechanisms. For this reason when evaluating the levels of GRs we should preferentially determine protein levels instead of gene expression. Here, we describe the detection by Western blotting of the GR (a and ß isoforms) protein, using macrodissected brain tissue

Feminists really do count : the complexity of feminist methodologies

We are delighted to be presenting this special issue on the topic of feminism and quantitative methods. We believe that such an issue is exceptionally timely. This is not simply because of ongoing debates around quantification within the field of feminism and women‟s studies. It is also because of debates within the wider research community about the development of appropriate methodologies that take account of new technological and philosophical concerns and are fit-for-purpose for researching contemporary social, philosophical, cultural and global issues. Two areas serve as exemplars in this respect and both speak to these combined wider social science and specifically feminist methodological concerns. The first is the increasing concern amongst social scientists with how the complexity of social life can be captured and analysed. Within feminism, this can be seen in debates about intersectionality that recognise the concerns arising from multiple social positions/divisions and associated power issues. As Denis (2008: 688) comments in respect of intersectional analysis „The challenge of integrating multiple, concurrent, yet often contradictory social locations into analyses of power relations has been issued. Theorising to accomplish this end is evolving, and we are struggling to develop effective methodological tools in order to marry theorising with necessary complex analyses of empirical data.‟ Secondly, new techniques and new data sources are now coming on line. This includes work in the UK of the ESRC National Data Strategy which has been setting out the priorities for the development of research data resources both within and across the boundaries of the social sciences. This will facilitate historical, longitudinal, interdisciplinary and mixed methodological research. And it may be the case that these developments facilitate the achievement of a longstanding feminist aim not simply for interdisciplinarity but for transdisciplinarity in epistemological and methodological terms

The use of beta-D-glucanase as a substitute for Novozyme 234 in immunofluorescence and protoplasting

Novozym 234 has been used for many years to prepare protoplasts of Aspergillus nidulans and other fungi for transformation. It has also been very useful in immunofluorescence studies for partially digesting walls of fixed hyphae or germlings to allow antibodies to penetrate into the cytoplasm. In recent years, the availability of Novozym 234 has become problematic, and we have searched for combinations of available enzymes that are suitable for protoplasting and immunofluorescence studies in A. nidulans

Too Much, Too Soon? Obergefell as Applied Equality Practice

Abrupt cultural change inevitably arouses anxieties, and often those fears provoke a retrograde reaction seeking to preserve the familiar status quo. When the world by which we define ourselves undergoes unexpected transitions, especially in directions that contradict the comfortable taken-for-granted assumptions that had been earlier enjoyed, we feel threatened. One needs only recall how the new standards of racial equality announced in Brown I and Brown II elicited virulent protests as some districts chose to shutter all public schools rather than have them become racially integrated. In the shadow of such traumas, it may seem an obvious lesson that progress should be slow and incremental, going only so far and as fast as the changes can be absorbed into the social habits. William Eskridge has offered a full-throated defense of modulating the rate of change in order to avoid these unintended consequences of modernization. Legal rights can be formally recognized, he says, but their enforcement should not outpace the acceptance of the new order. The prudence that Eskridge counsels appeals at an intuitive level, but is too abstract to provide useful guidance on how the real world should behave. This paper attempts to demonstrate an empirical means to distinguish situations when caution is prudent from moments when it is not by examining the context in which Eskridge himself frames his defense of incrementalism: same-sex marriage

Alanine-scanning mutagenesis of Aspergillus γ-tubulin yields diverse and novel phenotypes

This is the publisher's version, also available electronically from "www.molbiolcell.org".We have created 41 clustered charged-to-alanine scanning mutations of the mipA, γ-tubulin, gene of Aspergillus nidulans and have created strains carrying these mutations by two-step gene replacement and by a new procedure, heterokaryon gene replacement. Most mutant alleles confer a wild-type phenotype, but others are lethal or conditionally lethal. The conditionally lethal alleles exhibit a variety of phenotypes under restrictive conditions. Most have robust but highly abnormal mitotic spindles and some have abnormal cytoplasmic microtubule arrays. Two alleles appear to have reduced amounts of γ-tubulin at the spindle pole bodies and nucleation of spindle microtubule assembly may be partially inhibited. One allele inhibits germ tube formation. The cold sensitivity of two alleles is strongly suppressed by the antimicrotubule agents benomyl and nocodazole and a third allele is essentially dependent on these compounds for growth. Together our data indicate that γ-tubulin probably carries out functions essential to mitosis and organization of cytoplasmic microtubules in addition to its well-documented role in microtubule nucleation. We have also placed our mutations on a model of the structure of γ-tubulin and these data give a good initial indication of the functionally important regions of the molecule