1,324 research outputs found
Orality-Literacy Studies and the Unity of the Human Race
At the end of a symposium and volume such as this, with its array of varied and brilliant papers, it is difficult to know what to say by way of conclusion other than to express my heartfelt thanks to the impressive contributors in this symposium-festschrift and to its superb organizers. One thing that I am convinced should not be done is to try to summarize the many papers presented and the discussions following them. We have had our say on these matters already. I do not want to be in the position of the speaker who announced, "I am afraid that I have spoken about these matters all too long, so please let me conclude once more." What I shall try to do is to generalize out of all the thought provoking papers we have heard and to say something about orality literacy studies themselves as a whole. I shall have the temerity to generalize as widely as possible, for I have chosen as my subject nothing less than "Orality-Literacy Studies and the Unity of the Human Race." I do believe that what we have been about speaks in its own special way to the subject of human unity which is so urgent in our war-ridden and even war-mongering times
Before Textuality: Orality and Interpretation
Walter J. Ong needs little introduction here. His many books and myriad shorter works - among them The Presence of the Word (1967), Interfaces of the Word (1977), and Orality and Literacy (1982) - have established whole new areas of investigation in the cultural and psychological aspects of comparative studies in oral tradition. His Festschrift was published as volume 2, number 1 of Oral Tradition
Realizing Catholicism: Faith, Learning, and the Future
Father Ong gives a insightful talk on the relation of the Church\u27s Tradition in comparison to the ideas of Romanticism, the mentality of change in America, the development of technology, and the importance of the past to guide the way into the future. Father Ong highlights these ideas to better explain the essence of the term Catholic in that it is related and encompassed throughout the whole of scholarship.https://ecommons.udayton.edu/uscc_marianist_award/1000/thumbnail.jp
Hermeneutic forever : voice, text, digitization, and the "I"
Although we tend unreflectively to think of interpretation as carried on in language and as applied to linguistic expression in oral utterance or in text, interpretation can in fact be much larger than language in human life
NASA/USRA high altitude research aircraft. Gryphon: Soar like an eagle with the roar of a lion
At the equator, the ozone layer ranges from 65,000 to 130,000+ feet. This is beyond the capabilities of the ER-2, which is NASA's current high altitude reconnaissance aircraft. The Universities Space Research Association, in cooperation with NASA, is sponsoring an undergraduate program which is geared to designing an aircraft that can study the ozoned layer at the equator. This aircraft must be able to satisfy four mission profiles. Mission one is a polar mission which ranges from Chile to the South Pole and back to Chile, a total range of 6000 n. mi. at 100,000 feet with a 2500 lb. payload. The second mission is also a polar mission with a decreased altitude of 70,000 feet and an increased payload of 4000 lb. For the third mission, the aircraft will take-off at NASA Ames, cruise at 100,000 feet carrying a 2500 lb. payload, and land in Puerto Montt, Chile. The final mission requires the aircraft to take-off at NASA Ames, cruise at 100,000 feet with a 1000 lb. payload, make an excursion to 120,000 feet, and land at Howard AFB, Panama. All three missions require that a subsonic Mach number be maintained due to constraints imposed by the air sampling equipment. The aircraft need not be manned for all four missions. Three aircraft configurations were determined to be the most suitable for meeting the above requirements. The performance of each configuration is analyzed to investigate the feasibility of the project requirements. In the event that a requirement can not be obtained within the given constraints, recommendations for proposal modifications are given
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Common Variable Immunodeficiency Non-Infectious Disease Endotypes Redefined Using Unbiased Network Clustering in Large Electronic Datasets
Common variable immunodeficiency (CVID) is increasingly recognized for its association with autoimmune and inflammatory complications. Despite recent advances in immunophenotypic and genetic discovery, clinical care of CVID remains limited by our inability to accurately model risk for non-infectious disease development. Herein, we demonstrate the utility of unbiased network clustering as a novel method to analyze inter-relationships between non-infectious disease outcomes in CVID using databases at the United States Immunodeficiency Network (USIDNET), the centralized immunodeficiency registry of the United States, and Partners, a tertiary care network in Boston, MA, USA, with a shared electronic medical record amenable to natural language processing. Immunophenotypes were comparable in terms of native antibody deficiencies, low titer response to pneumococcus, and B cell maturation arrest. However, recorded non-infectious disease outcomes were more substantial in the Partners cohort across the spectrum of lymphoproliferation, cytopenias, autoimmunity, atopy, and malignancy. Using unbiased network clustering to analyze 34 non-infectious disease outcomes in the Partners cohort, we further identified unique patterns of lymphoproliferative (two clusters), autoimmune (two clusters), and atopic (one cluster) disease that were defined as CVID non-infectious endotypes according to discrete and non-overlapping immunophenotypes. Markers were both previously described {high serum IgE in the atopic cluster [odds ratio (OR) 6.5] and low class-switched memory B cells in the total lymphoproliferative cluster (OR 9.2)} and novel [low serum C3 in the total lymphoproliferative cluster (OR 5.1)]. Mortality risk in the Partners cohort was significantly associated with individual non-infectious disease outcomes as well as lymphoproliferative cluster 2, specifically (OR 5.9). In contrast, unbiased network clustering failed to associate known comorbidities in the adult USIDNET cohort. Together, these data suggest that unbiased network clustering can be used in CVID to redefine non-infectious disease inter-relationships; however, applicability may be limited to datasets well annotated through mechanisms such as natural language processing. The lymphoproliferative, autoimmune, and atopic Partners CVID endotypes herein described can be used moving forward to streamline genetic and biomarker discovery and to facilitate early screening and intervention in CVID patients at highest risk for autoimmune and inflammatory progression
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