10 research outputs found
Generating operative workflows for vestibular schwannoma resection: a two-stage Delphi consensus in collaboration with British Skull Base Society. Part 1: the retrosigmoid approach
- Author
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 10/10/2022
- Field of study
Objective: An operative workflow systematically compartmentalises operations into hierarchal components of phases, steps, instrument, technique errors and event errors. Operative workflow provides a foundation for education, training, and understanding of surgical variation. In Part 1 we present a codified operative workflow for the retrosigmoid approach to vestibular schwannoma resection. / Methods: A mixed-method consensus process of literature review, small group Delphi consensus, followed by a national Delphi consensus was performed in collaboration with British Skull Base Society (BSBS). Each Delphi round was repeated until data saturation and over 90% consensus was reached. / Results: Eighteen consultant skull base surgeons (10 neurosurgeons; 8 ENT) with median 17.9 years of experience (IQR 17.5 years) of independent practice participated. There was a 100% response rate across both Delphi rounds. The operative workflow for the retrosigmoid approach contained 3 phases and 40 unique steps: Phase 1: approach and exposure; Phase 2: tumour debulking and excision; Phase 3: closure. For the retrosigmoid approach, technique and event error for each operative step was also described. / Conclusions: We present Part 1 of a national, multi-centre, consensus-derived codified operative workflow for the retrosigmoid and approach to vestibular schwannomas that encompasses phases, steps, instruments, technique errors, and event errors. The codified retrosigmoid approach presented in this manuscript can serve as foundational research for future work, such as operative workflow analysis or neurosurgical simulation and education
CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service
- Author
- Al-Tamimi Y
- Alalade AF
- Albanese E
- Bailey M
- Brennan PM
- Brodbelt AR
- Chalmers A
- Chan HW
- Chowdhury YA
- Colombo F
- Coope DJ
- Cundliffe S
- D'Urso PI
- Elmoslemany T
- Entwistle H
- Evans RM
- Ewbank FG
- Fielding R
- Fountain DM
- Gkolemis C
- Grundy PL
- Hammerbeck-Ward C
- Hasan MT
- Hilling M
- Hutchinson PJ
- Jenkinson MD
- Jeyaretna DS
- Karabatsou K
- King AT
- Kolias AG
- Lau JY
- Laurente RM
- Leggate J
- Lewis R
- MacLean J
- McBain C
- McKenna GS
- McSorley NJ
- Millward CP
- Molloy E
- Pathmanaban ON
- Patkar P
- Phang I
- Piper RJ
- Plaha P
- Poon MTC
- Powell J
- Price SJ
- Rominiyi O
- Rutherford SA
- Sage W
- Santarius T
- Shumon S
- Silva IL
- Sinha S
- Sitaraman M
- Smith SJ
- Solomou G
- Solth A
- Surash S
- Thakur B
- Thomson S
- Wadeson A
- Watts C
- Wykes V
- Zafar MR
- Publication venue
- Neuro-Oncology Advances
- Publication date
- 01/01/2021
- Field of study
BackgroundThe COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors.MethodsWe performed a multicenter prospective study of all adult patients discussed in weekly neuro-oncology and skull base multidisciplinary team meetings who had a newly diagnosed or recurrent intracranial (excluding pituitary) tumor between 01 April and 31 May 2020. All patients had at least 30-day follow-up data. Descriptive statistical reporting was used.ResultsThere were 1357 referrals for newly diagnosed or recurrent intracranial tumors across 15 neuro-oncology centers. Of centers with all intracranial tumors, a change in initial management was reported in 8.6% of cases (n = 104/1210). Decisions to change the management plan reduced over time from a peak of 19% referrals at the start of the study to 0% by the end of the study period. Changes in management were reported in 16% (n = 75/466) of cases previously recommended for surgery and 28% of cases previously recommended for chemotherapy (n = 20/72). The reported SARS-CoV-2 infection rate was similar in surgical and non-surgical patients (2.6% vs. 2.4%, P > .9).ConclusionsDisruption to neuro-oncology services in the UK caused by the COVID-19 pandemic was most marked in the first month, affecting all diagnoses. Patients considered for chemotherapy were most affected. In those recommended surgical treatment this was successfully completed. Longer-term outcome data will evaluate oncological treatments received by these patients and overall survival
Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing
- Author
- Afridi S
- Anup R
- Axon P
- Barazi S
- Barwell J
- Blesing C
- Bowers NL
- Browne K
- Cogswell L
- Crabtree R
- Dalton L
- Dodridge C
- Donnelly N
- Duff C
- Emmanouil B
- English M
- Evans DG
- Everett V
- Ferner RE
- Foweraker K
- Freeman SR
- Gair JJ
- Gamazo N
- Giele H
- Halliday D
- Hammerbeck-Ward C
- Hammerbeck-Ward C
- Hammond C
- Hanemann CO
- Harkness EF
- Harris F
- Heney D
- Henley S
- Henshaw K
- Hensiek A
- Howard W
- Irving R
- Jarvis N
- Jefferies S
- Jena R
- Jeyaretna S
- Kamaly-Asl I
- Kellett M
- Kerr R
- Kilday J-P
- King AT
- Knight R
- Kurian J
- Laitt R
- Lascelles K
- Lloyd SKL
- Mace E
- Macfarlane R
- MacKeith S
- Malluci C
- Mannion R
- Maratos E
- Mawman D
- May A
- McBain C
- McCabe M
- Monksfield P
- Mullin R
- Muthusamy B
- Nduka C
- Nicholson J
- Nunn T
- O'Driscoll M
- Obholzer R
- Parry A
- Pathmanaban ON
- Perry M
- Perry M
- Pretorius P
- Price R
- Ragge N
- Ramsden J
- Rands G
- Raymond L
- Redman C
- Rutherford S
- Rutherford SA
- Saeed S
- Sanghera P
- Scoffings ZD
- Sharif S
- Shaw A
- Skilbeck C
- Smith MJ
- Smyth C
- Stapleton E
- Stivaros S
- Swampillai A
- Tam YC
- Taylor A
- Taylor SSR
- Thomas N
- Thomas O
- Thomson S
- Tobi S
- Tomkins H
- Trump S
- Tysome J
- Vanat TL
- Vassallo G
- Wallace AJ
- Williams V
- Wilson S
- Woolrich R
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 01/07/2019
- Field of study
Purpose
We have evaluated deficiencies in existing diagnostic criteria for neurofibromatosis 2 (NF2).
Methods
Two large databases of individuals fulfilling NF2 criteria (n = 1361) and those tested for NF2 variants with criteria short of diagnosis (n = 1416) were interrogated. We assessed the proportions meeting each diagnostic criterion with constitutional or mosaic NF2 variants and the positive predictive value (PPV) with regard to definite diagnosis.
Results
There was no evidence for usefulness of old criteria “glioma“ or “neurofibroma.” “Ependymoma” had 100% PPV and high levels of confirmed NF2 diagnosis (67.7%). Those with bilateral vestibular schwannoma (VS) alone aged ≥60 years had the lowest confirmation rate (6.6%) and reduced PPV (80%). Siblings as a first-degree relative, without an affected parent, had 0% PPV. All three individuals with unilateral VS and an affected sibling were proven not to have NF2. The biggest overlap was with LZTR1-associated schwannomatosis. In this category, seven individuals with unilateral VS plus ≥2 nondermal schwannomas reduced PPV to 67%.
Conclusions
The present study confirms important deficiencies in NF2 diagnostic criteria. The term “glioma” should be dropped and replaced by “ependymoma.” Similarly “neurofibroma” should be removed. Dropping “sibling” from first-degree relatives should be considered and testing of LZTR1 should be recommended for unilateral VS
Outcome after severe head injury: focal surgical lesions do not imply a better Glasgow Outcome Score than diffuse injuries at 3 months.
- Publication venue
- Publication date
- 01/04/2009
- Field of study
Increased neural progenitors in vascular dementia.
- Publication venue
- Publication date
- 01/01/2010
- Field of study
The comparable tumour microenvironment in sporadic and <i>NF2</i>-related schwannomatosis vestibular schwannoma.
- Publication venue
- Publication date
- 01/07/2023
- Field of study
Increased neural progenitors in vascular dementia
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/02/2010
- Field of study
High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/08/2018
- Field of study
Surgeons’ experience of venous risk with CPA surgery
- Author
- A Koerbel
- A Tahara
- A Yang
- AC Ivy
- AS Jakola
- BD Liebelt
- C Dumot
- CL Taylor
- DL Sackett
- DL Sackett
- E Zanoletti
- G Anichini
- G Milano
- IH Tekkok
- J Hernesniemi
- J Masuoka
- K Adachi
- K Matsushima
- L Cheng
- LA Palinkas
- M Rawlins
- MD Rawlins
- MD Staudt
- MH Murad
- MR McLaughlin
- NJ Patel
- ON Pathmanaban
- P Weindling
- PJ Jannetta
- T Mathiesen
- T Matsushima
- T Matsushima
- T Ueyama
- T Watanabe
- TC Hollon
- V Narayan
- Y Seo
- Y Suzuki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- Abellán M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Za’nouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes García F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akhter Rahman MM
- Akilli H
- Akin E
- Akkour K
- Akkulak Murat
- Akmenkalne L
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
- Alam F
- Alam N
- Alam R
- Alameer Ehab
- Alamri A
- Alamri Alex
- Alanbuki A
- Alatar A
- Alawneh F
- Alazawi D
- Albertsmeier M
- Albertsmeiers Markus
- Albi Martin B
- Alburakan A
- Alcaide Matas F
- Alconchel F
- Aldayri Z
- Aldecoa Ansorregui I
- Alderson Derek
- Aldokali N
- Aleksić L
- Alemanno G
- Alexoudi V
- Alfaro-Goldaracena A
- Alfieri S
- Alghamdi M
- Alhalal H
- Alhamed A
- Alharthi M
- Alharthi R
- Alhassan B
- Alhassan N
- Alhefdhi A
- Ali karar AA
- Ali AK
- Ali M
- Ali S
- Aliyeva Z
- Aljanadi F
- Aljiffry M
- Alkadeeki GZ
- Alkarak S
- Allemand C
- Allison J
- Almalik O
- Almasri M
- Almeciga A
- Almeida A
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- Almeida JI
- Almgla N
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- Alnumani T
- Alobeed O
- Alomair A
- Alonso de la Fuente N
- Alonso Poza A
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- Alotaibi N
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- Alresaini F
- Alriyees L
- Alsaif A
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- Alsalamah R
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- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani M
- Alshammari S
- Alshareea E
- Alsharif F
- Alshaygy I
- Alshryda Sattar
- Alsobhi S
- Althobaiti W
- Altintoprak F
- Alurralde C
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- Alyami M
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- Amaral MJ
- Ameerally P
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- Chaar Mohammad
- Chaar Mohammad Abou
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- on behalf of the COVIDSurg Collaborative
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- Solth A
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- Sorbi F
- Soreide Kjetil
- Soriano AI
- Sorour TM
- Sorrentino L
- Sorribas Grifell M
- Sosa MV
- Soto Montesinos C
- Souadka A
- Soulikia K
- Sousa Fernandes M
- Sousa R
- Sousa S
- Soyak B
- Spagni G
- Spalding D
- Spampinato MG
- Sparavigna M
- Spartalis E
- Spencer N
- Speth U
- Spinelli A
- Spinelli Antonino
- Spriano G
- Spurnic I
- Sravanam S
- Srbinovic L
- Sreedharan L
- Srikanth P
- Srinathan S
- Sriram RK
- Srishankar S
- Ssentongo A
- Ssentongo P
- St. John S
- Stafford J
- Stanimirovic A
- Stavrinidou O
- Stavroglou A
- Stavroulias D
- Stebbing J
- Steel B
- Steele C
- Stefanovic A
- Steidle C
- Steiner MA
- Steinke J
- Stepanyan A
- Stevens K
- Stevenson J
- Stevic D
- Stewart GD
- Stewart Grant D
- Stewart Grant D.
- Stewart KE
- Stojiljkovic D
- Stranz C
- Stroman L
- Stylianides N
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sultana A
- Sumrak S
- Sund M
- Sund Malin
- Sundar MRCOG, Sudha
- Sundar S
- Sundar Sudha
- Sundaram Venkatesan G
- Sureshkumar Shah N
- Suszták N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Symeonidis D
- Szatmary P
- Szpytma M
- Szubota I
- Sánchez Aniceto G
- Sánchez del Pueblo C
- Sánchez Fuentes N
- Sánchez-García S
- Sánchez-Pernaute A
- Sánchez-Rubio M
- Tabiri Stephen
- Taddei A
- Tadic B
- Taffurelli M
- Taflin H
- Taggarsi M
- Tagliabue M
- Tahhan G
- Taibi A
- Tailor A
- Takeda F
- Talal El-Abur I
- Talukder S
- Talwar R
- Tamini N
- Tammaro T
- Tan JA
- Tan JR
- Tan KL
- Tan XS
- Tanabalan C
- Tanal M
- Tanase Y
- Tang A
- Tang CY
- Tanzanu M
- Tartaglia D
- Tasis N
- Taskiran C
- Tatar OC
- Tatsis D
- Tavares F
- Tayeh S
- Taylor Elliott H
- Tebala GD
- Tedde A
- Tedde M
- Teh C
- Teh E
- Teixeira J
- Teixeira M
- Tejero-Pintor FJ
- Tenreiro N
- Teoh LY
- Tepetes K
- Tercero-Uribe AI
- Terra RM
- Tesei M
- Testa V
- Testelin S
- Teves M
- Tewari N
- Tezas S
- Thaha M
- Thakur B
- Tham D
- Thanapal MR
- Thekinkattil Dinesh
- Thekkinkattil D
- Theodosopoulos T
- Theophilidou E
- Theophilou G
- Thiruchelvam J
- Thole S
- Thomas A
- Thomas E
- Thomas M
- Thomas R
- Thompson A
- Thompson D
- Thornhill M
- Thrumurthy S
- Thulasiraman SV
- Tilaveridis I
- Timbrell S
- Timon C
- Tingle S
- Tirloni L
- Tirotta F
- Tirotta Fabio
- Titu S
- Tiwari Abhinav
- Todorovic M
- Toia F
- Tojal A
- Tolani MA
- Tonini V
- Toogood G
- Tooulias A
- Topczewski TE
- Torales J
- Tormey S
- Torne A
- Tornese S
- Torné R
- Torres Arcos C
- Torres A
- Torretta S
- Townend D
- Townend P
- Townend Philip
- Townson A
- Trabulsi N
- Travaglio E
- Tribillon E
- Trivic A
- Troncoso Pereira P
- Tropeano FP
- Trout Isobel M
- Truant S
- Trujillo Díaz J
- Tsai L
- Tsaousis V
- Tsarkov P
- Tsiamalou I
- Tsiaoussis J
- Tsibulak I
- Tsirlis T
- Tsolakidis D
- Tsoulfas G
- Tsoulfas Georgios
- Tucci R
- Tudela M
- Tudisco R
- Tufo A
- Tugmen C
- Tulina I
- Tuncer K
- Turkington R
- Turnage K
- Turnbull A
- Turrado-Rodriguez V
- Turri G
- Tustin H
- Tutoveanu G
- Tuveri M
- Tweedle E
- Tzedakis S
- Tzerbinis H
- Tzovaras G
- Ugarte-Sierra B
- Uludağ SS
- Umair M
- Umar M
- Underwood C
- Uno M
- Uras C
- Urbani A
- Urbieta A
- Usai A
- Usandivaras M
- Uslu G
- Uson-Bouthelier T
- Usseglio J
- Utkan NZ
- Uyanik MS
- Uzunoglu FG
- Vaccarella G
- Vahtsevanos K
- Valbuena Jabares V
- Valdes-Hernandez J
- Valente da Costa A
- Valero Soriano M
- Valero R
- Vallance A
- Vallance Abigail
- Valle Rubio A
- Valtzoglou V
- Valverde S
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Duijvendijk P
- Van Heinsbergen M
- Van Houdt W
- van Ramshorst Gabrielle H
- Van Wyngaard T
- Vanounou T
- Varazzani A
- Vargas L
- Varley I
- Varma M
- Vasljević J
- Vassiliu P
- Vatansever D
- Vatish J
- Vatish M
- Vaz Pereira R
- Vaz OP
- Vaz S
- Vazquez fernandez A
- Veiga D
- Velagapudi S
- Velchuru V
- Velickovic D
- Velidedeoglu M
- Venetis G
- Venn M
- Venn Mary L
- Venn Mary L.
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Vidakovic S
- Videira JF
- Videria Jose Flavio
- Vidya R
- Vidya Raghavan
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vieira P
- Vignali A
- Vigorita V
- Vijayan D
- Vilatoba M
- Vilendecic Z
- Villalabeitia Ateca I
- Vimalachandran D
- Vimalachandran Dale
- Vimalchandran Dale
- Vinayagam R
- Violante T
- Visgauss J
- Viswambaram P
- Viswanath Y
- Vitali A
- Vitone L
- Vives RV
- Vo UG
- Vogel J
- Vollkommer T
- Von Papen M
- Vovola F
- Vucic N
- Vujanac V
- Wade R
- Wadham B
- Waheed S
- Wai K
- Wali A
- Walker C
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- Walkes K
- Wallwork K
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- Walton T
- Waqar SH
- Warburton H
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- Ward S
- Waris Farooka M
- Warren O
- Warren Oliver J
- Waseem S
- Wasim T
- Watson D
- Watson LJ
- Watson N
- Weaver H
- Webber L
- Wedderburn Duane
- Weitz J
- Welsch T
- Wensley F
- Werner J
- West C
- West D
- Westwood E
- Whelan M
- Whelan P
- Whisker L
- Whitehall E
- Whitmore H
- Wilkin R
- Wilkin Richard JW
- Wilkins A
- Wilkins Alex
- Williams G
- Williams J
- Williams K
- Williams MA
- Williams T
- Williamson K
- Wilson M
- Wimberger P
- Wimmer A
- Winnand P
- Winter D
- Winter S
- Winter Stuart C
- Wolfer S
- Wong MPK
- Wong S
- Wong WJ
- Woodham A
- Woodun H
- Worku D
- Wright G
- Wright Naomi
- Wullschleger M
- Wustrack R
- Xenaki S
- Xu MJ
- Xyda SE
- Xynos E
- Yahaya AS
- Yang W
- Yassin N
- Ye G
- Yesantharao P
- Yetkin G
- Yeşilyurt D
- Yiallourou A
- Yıldırım A
- Yildiz A
- Ying Y
- Yip V
- Yordanov S
- Young R
- Yousof EA
- Youssef A
- Youssef M
- Yurttas C
- Yánez C
- Yüksel E
- Zacharoulis D
- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zegarac M
- Zelić M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortúzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Ângelo M
- Älgå A
- Çapoğlu R
- Çelebi F
- Çolak E
- Öfner D
- Öhlberger L
- Öğücü H
- Überrück L
- Ćoza I
- Šimko K
- Šćepanović V
- Žatecký J
- Камалов А
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study