Early effects of estrogen on the rat ventral prostate

Complex interactions between androgen and estrogen (E2) regulate prostatic development and physiology. We analyzed the early effects of a high single dose of E2 (25 mg/kg body weight) and castration (separately or combined) on the adult 90-day-old male Wistar rat ventral prostate. Androgen levels, prostate weight, and the variation in the relative and absolute volume of tissue compartments and apoptotic indices were determined for 7 days. Castration and exogenous E2 markedly reduced ventral prostate weight (about 50% of the control), with a significant reduction in the epithelial compartment and increased stroma. The final volume of the epithelium was identical at day 7 for all treatments (58.5% of the control). However, E2 had an immediate effect, causing a reduction in epithelial volume as early as day 1. An increase in smooth muscle cell volume resulted from the concentration of these cells around the regressing epithelium. The treatments resulted in differential kinetics in epithelial cell apoptosis. Castration led to a peak in apoptosis at day 3, with 5% of the epithelial cells presenting signs of apoptosis, whereas E2 caused an immediate increase (observed on day 1) and a sustained (up to day 7) effect. E2 administration to castrated rats significantly increased the level of apoptosis by day 3, reaching 9% of the epithelial cells. The divergent kinetics between treatments resulted in the same levels of epithelial regression after 7 days (~30% of control). These results show that E2 has an immediate and possibly direct effect on the prostate, and anticipates epithelial cell death before reducing testosterone to levels as low as those of castrated rats. In addition, E2 and androgen deprivation apparently cause epithelial cell death by distinct and independent pathways.48749

Inter- and intra-annual variability of wave energy in Northern mainland Portugal: Application to the HiWave-5 project

Ocean wave energy capacity has been pointed out as one of the unexplored renewable energy sources to help reach net zero carbon emissions by 2050, contributing to meeting the European Green Deal targets. However, despite the broad range of wave energy converter technologies already developed in a sustainable and economic model, there is still a lack of structured projects with high performance beyond the prototype stage. This paper investigates the potential for large-scale electricity production by the innovative HiWave-5 project in Aguçadoura (on the Northern coast of mainland Portugal). Wind–wave data (1950–2020) from the ERA5 reanalysis model are used to estimate inter- and intra-annual wave energy variability in Aguçadoura. ERA5 data is compared with field wind–wave data recorded between 2012–2019 near the study area. A mean wave power resource of 25.84 kW/m is obtained, for a possible device capture equal to 119.45 kW, despite a considerable intra-annual variability (ranging between 8.03 and 47.57 kW/m) and inter-annual variability (between 18.29 and 35.47 kW/m). Results show that local wave conditions do not substantially compromise the absolute performance of the device, given its survival limitations to adverse conditions. Considering a Levelized Cost of Energy of around €60/MWh, an annual investment of €62 885 is estimated, tending to meet targets for large sustainable electricity generation with the exponential growth expected until 2030, aided by the increase of devices in an energy farm concept. Wave power resources estimated using ERA5 data can underestimate about 7.20% values obtained with the wave buoy data.The second and third authors thank FCT/MCTES for the financial support to CESAM, Portugal (UIDP/50017/2020+UIDB/50017/ 2020+ LA/P/0094/2020), through national funds. The authors also want to thank the anonymous reviewers for their useful comments and suggestions.info:eu-repo/semantics/publishedVersio

Effects Of Crossed Electric And Magnetic Fields On The Electronic And Excitonic States In Bulk Gaas And Gaas Ga1-x Alx As Quantum Wells

The variational procedure in the effective-mass and parabolic-band approximations is used in order to investigate the effects of crossed electric and in-plane magnetic fields on the electronic and exciton properties in semiconductor heterostructures. Calculations are performed for bulk GaAs and GaAs Ga1-x Alx As quantum wells, for applied magnetic fields parallel to the layers and electric fields in the growth direction, and it is shown that the combined effects on the heterostructure properties of the applied crossed electric and magnetic fields and the direct coupling between the center-of-mass and internal exciton motions may be dealt with via a simple parameter representing the spatial distance between the centers of the electron and hole magnetic parabolas. Exciton properties are analyzed by using a simple hydrogenlike envelope excitonic wave function and present theoretical results are found in fair agreement with available experimental measurements on the diamagnetic shift of the photoluminescence peak position of GaAs Ga1-x Alx As quantum wells under in-plane magnetic fields. © 2007 The American Physical Society.753Whittaker, D.M., Fisher, T.A., Simmonds, P.E., Skolnick, M.S., Smith, R.S., (1991) Phys. Rev. Lett., 67, p. 887. , PRLTAO 0031-9007 10.1103/PhysRevLett.67.887Fritze, M., Perakis, I.E., Getter, A., Knox, W., Goossen, K.W., Cunningham, J.E., Jackson, S.A., (1996) Phys. Rev. Lett., 76, p. 106. , PRLTAO 0031-9007 10.1103/PhysRevLett.76.106Butov, L.V., Mintsev, A.V., Lozovik, Y.E., Campman, K.L., Gossard, A.C., (2000) Phys. Rev. B, 62, p. 1548. , PRBMDO 0163-1829 10.1103/PhysRevB.62.1548Parlangeli, A., Christianen, P.C.M., Maan, J.C., Soerensen, C.B., Lindelof, P.E., (2000) Phys. 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A 2d Honeycomb Photonic Crystal Under Applied Magnetic Fields

The band-structure properties of a photonic two-dimensional honeycomb lattice formed by cylindrical semiconductor shell rods with dielectric permitivities ε 1 and ε 2, and embedded in a background with permitivity ε 3, is studied by using an standard plane-wave expansion. The properties of bandgaps and density of states, considering dispersive dielectric responses, are investigated together with the possibility of fabricating systems with tunable photonic bandgaps, due to the Voigt magneto-optical effect, under the influence of an external magnetic field. © 2008 SPIE.7138J. D. Joannopoulos, R. D. Meade, J. N. Winn, Photonic Crystals: Molding the Flow of Light, Princeton University Press, Princeton, 1995E. Istrate and E. H. Sargent, Rev. Mod. Phys. 78, 455 (2006)Xu, C., Hu, X., Li, Y., Liu, X., Fu, R., Zi, J., (2003) Phys. Rev. B, 68, p. 193201Kee, C.-S., Kim, J.-E., Park, H.Y., Park, I., Lim, H., (2000) Phys. Rev. B, 61, p. 15523Anderson, C.M., Giapis, K.P., (1996) Phys. Rev. Lett, 77, p. 2949Rezaei, B., Kalafi, M., (2006) Optics Commun, 266, p. 159Busch, K., John, S., (1999) Phys. Rev. Lett, 83, p. 967S. B. Cavalcanti, M. de Dios-Leyva, E. Reyes-Gómez, and L. E. Oliveira, Phys. Rev. B 74, 153102 (2006)ibid., Phys. Rev. E 75, 026607 (2007)Ho, K.M., Chan, C.T., Soukoulis, C.M., (1990) Phys. Rev. Lett, 65, p. 315

Controlling quantum entanglement through photocounts

We present a protocol to generate and control quantum entanglement between the states of two subsystems (the system ${\cal S}$) by making measurements on a third subsystem (the monitor ${\cal M}$), interacting with ${\cal S}$. For the sake of comparison we consider first an ideal, or instantaneous projective measurement, as postulated by von Neumann. Then we compare it with the more realistic or generalized measurement procedure based on photocounting on ${\cal M}$. Further we consider that the interaction term (between ${\cal S}$ and ${\cal M}$) contains a quantum nondemolition variable of ${\cal S}$ and discuss the possibility and limitations for reconstructing the initial state of ${\cal S}$ from information acquired by photocounting on ${\cal M}$.Comment: 12 pages, 3 figures, accepted for publication in Phys. Rev

Synaptic Transmission: Looking for Clues to Autism Spectrum Disorders (ASD) Etiology in Copy Number Variants Containing Synaptic Genes

Copy Number Variants (CNVs) play an important role in susceptibility to ASD, often mediated by the deletion or duplication of genes involved in synaptic structure and function. Increasing evidence suggests a central role for defects in synaptic structure and function in the pathogenesis of non-syndromic ASD. In this study we tested the hypothesis of an enrichment in CNVs encompassing synaptic transmission genes in ASDThis work was supported by the fellowships SFRH/BD/79081/2011 to BO, SFRH/BPD/74739/2010 to ICC and SFRH/BPD/64281/2009 to CC from Fundação para a Ciência e a Tecnologia (FCT; Portugal)

Copy number variants involving components of the glutamatergic synaptic pathway in ASD patients

This work was supported by the fellowships SFRH/BD/79081/2011 to BO, SFRH/BPD/74739/2010 to ICC and SFRH/BPD/64281/2009 to CC from Fundação para a Ciência e a Tecnologia (FCT; Portugal).Copy Number Variants (CNVs) play an important role in susceptibility to Autism Spectrum Disorders (ASD), in particular when deleting or duplicating genes involved in synaptic structure and function such as glutamatergic synapse genes. Identifying CNVs of etiologic relevance for ASD that include glutamatergic genes may contribute to the understanding of glutamate-related pathogenic mechanisms in this disorder

Effects Of Non-parabolicity And In-plane Magnetic Fields On The Cyclotron Effective Mass And G -factor In Gaas-(ga,al)as Quantum Wells

The envelope-function approach is used to theoretically study the effects of in-plane magnetic fields on the cyclotron effective mass and Landé g -factor associated to conduction electrons in single GaAs-(Ga,Al)As quantum wells. Non-parabolic and anisotropy effects are included in the calculations within the Ogg-McCombe effective Hamiltonian to describe the electron states in the semiconductor heterostructure. The electronic structure and both the cyclotron effective mass and Landé g -factor were obtained, by expanding the corresponding envelope wave functions in terms of harmonic-oscillator wave functions, as functions of the in-plane magnetic field, cyclotron orbit-center position, and quantum-well widths. This procedure allows us to consider the different terms in the Hamiltonian on equal footing, avoiding therefore the use of approximate methods to obtain the envelope wave functions and the corresponding energy spectrum. 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Monitoring Single-point Dressers Using Fuzzy Models

AbstractGrinding causes progressive dulling and glazing of the grinding wheel grains and clogging of the voids on the wheel's surface with ground metal dust particles, which gradually increases the grinding forces. The condition of the grains at the periphery of a grinding wheel strongly influences the damage induced in a ground workpiece. Therefore, truing and dressing must be carried out frequently. Dressing is the process of conditioning the grinding wheel surface to reshape the wheel when it has lost its original shape through wear, giving the tool its original condition of efficiency. Despite the very broad range of dressing tools available today, the single-point diamond dresser is still the most widely used dressing tool due to its great versatility. The aim of this work is to predict the wear level of the single-point dresser based on acoustic emission and vibration signals used as input variables for fuzzy models. Experimental tests were performed with synthetic diamond dressers on a surface-grinding machine equipped with an aluminum oxide grinding wheel. Acoustic emission and vibration sensors were attached to the tool holder and the signals were captured at 2MHz. During the tests, the wear of the diamond tip was measured every 20 passes using a microscope with 10 to 100 X magnification. A study was conducted of the frequency content of the signals, choosing the frequency bands that best correlate with the diamond's wear. Digital band-pass filters were applied to the raw signals, after which two statistics were calculated to serve as the inputs for the fuzzy models. The results indicate that the fuzzy models using the aforementioned signal statistics are highly effective for predicting the wear level of the dresser

Self-similarity And Anti-self-similarity Of The Effective Landé G Factor In Gaas-(ga,al)as Fibonacci Superlattices Under In-plane Magnetic Fields

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