732 research outputs found
Soil carbon management in large-scale Earth system modelling:implications for crop yields and nitrogen leaching
Croplands are vital ecosystems for human well-being and provide important ecosystem services such as crop yields, retention of nitrogen and carbon storage. On large (regional to global)-scale levels, assessment of how these different services will vary in space and time, especially in response to cropland management, are scarce. We explore cropland management alternatives and the effect these can have on future C and N pools and fluxes using the land-use-enabled dynamic vegetation model LPJ-GUESS (LundâPotsdamâJena General Ecosystem Simulator). Simulated crop production, cropland carbon storage, carbon sequestration and nitrogen leaching from croplands are evaluated and discussed. Compared to the version of LPJ-GUESS that does not include land-use dynamics, estimates of soil carbon stocks and nitrogen leaching from terrestrial to aquatic ecosystems were improved. Our model experiments allow us to investigate trade-offs between these ecosystem services that can be provided from agricultural fields. These trade-offs are evaluated for current land use and climate and further explored for future conditions within the two future climate change scenarios, RCP (Representative Concentration Pathway) 2.6 and 8.5. Our results show that the potential for carbon sequestration due to typical cropland management practices such as no-till management and cover crops proposed in previous studies is not realised, globally or over larger climatic regions. Our results highlight important considerations to be made when modelling CâN interactions in agricultural ecosystems under future environmental change and the effects these have on terrestrial biogeochemical cycles
Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy.
Limited data are available regarding the evolution over time of the rate of sudden unexpected death in epilepsy patients (SUDEP) in drug-resistant epilepsy. The objective is to analyze a database of 40Â 443Â patients with epilepsy implanted with vagus nerve stimulation (VNS) therapy in the United States (from 1988 to 2012) and assess whether SUDEP rates decrease during the postimplantation follow-up period.
Patient vital status was ascertained using the Centers for Disease Control and Prevention's National Death Index (NDI). An expert panel adjudicated classification of cause of deaths as SUDEP based on NDI data and available narrative descriptions of deaths. We tested the hypothesis that SUDEP rates decrease with time using the Mann-Kendall nonparametric trend test and by comparing SUDEP rates of the first 2 years of follow-up (years 1-2) to longer follow-up (years 3-10).
Our cohort included 277Â 661 person-years of follow-up and 3689Â deaths, including 632 SUDEP. Primary analysis demonstrated a significant decrease in age-adjusted SUDEP rate during follow-up (SÂ =Â -27 PÂ =Â .008), with rates of 2.47/1000 for years 1-2 and 1.68/1000 for years 3-10 (rate ratio 0.68; 95% confidence interval [CI] 0.53-0.87; PÂ =Â .002). Sensitivity analyses confirm these findings.
Our data suggest that SUDEP risk significantly decreases during long-term follow-up of patients with refractory epilepsy receiving VNS Therapy. This finding might reflect several factors, including the natural long-term dynamic of SUDEP rate, attrition, and the impact of VNS Therapy. The role of each of these factors cannot be confirmed due to the limitations of the study
A search for two body muon decay signals
Lepton family number violation is tested by searching for
decays among the 5.8 positive muon decay events analyzed by the
TWIST collaboration. Limits are set on the production of both massless and
massive bosons. The large angular acceptance of this experiment allows
limits to be placed on anisotropic decays, which can arise
from interactions violating both lepton flavor and parity conservation.
Branching ratio limits of order are obtained for bosons with masses
of 13 - 80 MeV/c and with different decay asymmetries. For bosons with
masses less than 13 MeV/c the asymmetry dependence is much stronger and
the 90% limit on the branching ratio varies up to . This is
the first study that explicitly evaluates the limits for anisotropic two body
muon decays.Comment: 7 pages, 5 figures, 2 tables, accepted by PR
Production of antihydrogen at reduced magnetic field for anti-atom trapping
We have demonstrated production of antihydrogen in a 1T solenoidal
magnetic field. This field strength is significantly smaller than that used in
the first generation experiments ATHENA (3T) and ATRAP (5T). The
motivation for using a smaller magnetic field is to facilitate trapping of
antihydrogen atoms in a neutral atom trap surrounding the production region. We
report the results of measurements with the ALPHA (Antihydrogen Laser PHysics
Apparatus) device, which can capture and cool antiprotons at 3T, and then
mix the antiprotons with positrons at 1T. We infer antihydrogen production
from the time structure of antiproton annihilations during mixing, using mixing
with heated positrons as the null experiment, as demonstrated in ATHENA.
Implications for antihydrogen trapping are discussed
Centrifugal separation and equilibration dynamics in an electron-antiproton plasma
Charges in cold, multiple-species, non-neutral plasmas separate radially by
mass, forming centrifugally-separated states. Here, we report the first
detailed measurements of such states in an electron-antiproton plasma, and the
first observations of the separation dynamics in any centrifugally-separated
system. While the observed equilibrium states are expected and in agreement
with theory, the equilibration time is approximately constant over a wide range
of parameters, a surprising and as yet unexplained result. Electron-antiproton
plasmas play a crucial role in antihydrogen trapping experiments
Measurement of the Muon Decay Parameter delta
The muon decay parameter delta has been measured by the TWIST collaboration.
We find delta = 0.74964 +- 0.00066(stat.) +- 0.00112(syst.), consistent with
the Standard Model value of 3/4. This result implies that the product Pmuxi of
the muon polarization in pion decay, Pmu, and the muon decay parameter xi falls
within the 90% confidence interval 0.9960 < Pmuxi < xi < 1.0040. It also has
implications for left-right-symmetric and other extensions of the Standard
Model.Comment: Extended to 5 pages. Referee's comments answere
Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension of 100 nanometers or less) presents a dilemma to regulators regarding hazard identification. The International Life Sciences Institute Research Foundation/Risk Science Institute convened an expert working group to develop a screening strategy for the hazard identification of engineered nanomaterials. The working group report presents the elements of a screening strategy rather than a detailed testing protocol. Based on an evaluation of the limited data currently available, the report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for nanomaterials. Oral, dermal, inhalation, and injection routes of exposure are included recognizing that, depending on use patterns, exposure to nanomaterials may occur by any of these routes. The three key elements of the toxicity screening strategy are: Physicochemical Characteristics, In Vitro Assays (cellular and non-cellular), and In Vivo Assays. There is a strong likelihood that biological activity of nanoparticles will depend on physicochemical parameters not routinely considered in toxicity screening studies. Physicochemical properties that may be important in understanding the toxic effects of test materials include particle size and size distribution, agglomeration state, shape, crystal structure, chemical composition, surface area, surface chemistry, surface charge, and porosity. In vitro techniques allow specific biological and mechanistic pathways to be isolated and tested under controlled conditions, in ways that are not feasible in in vivo tests. Tests are suggested for portal-of-entry toxicity for lungs, skin, and the mucosal membranes, and target organ toxicity for endothelium, blood, spleen, liver, nervous system, heart, and kidney. Non-cellular assessment of nanoparticle durability, protein interactions, complement activation, and pro-oxidant activity is also considered. Tier 1 in vivo assays are proposed for pulmonary, oral, skin and injection exposures, and Tier 2 evaluations for pulmonary exposures are also proposed. Tier 1 evaluations include markers of inflammation, oxidant stress, and cell proliferation in portal-of-entry and selected remote organs and tissues. Tier 2 evaluations for pulmonary exposures could include deposition, translocation, and toxicokinetics and biopersistence studies; effects of multiple exposures; potential effects on the reproductive system, placenta, and fetus; alternative animal models; and mechanistic studies
Alpha Antihydrogen Experiment
ALPHA is an experiment at CERN, whose ultimate goal is to perform a precise
test of CPT symmetry with trapped antihydrogen atoms. After reviewing the
motivations, we discuss our recent progress toward the initial goal of stable
trapping of antihydrogen, with some emphasis on particle detection techniques.Comment: Invited talk presented at the Fifth Meeting on CPT and Lorentz
Symmetry, Bloomington, Indiana, June 28-July 2, 201
Antihydrogen and mirror-trapped antiproton discrimination: Discriminating between antihydrogen and mirror-trapped antiprotons in a minimum-B trap
Recently, antihydrogen atoms were trapped at CERN in a magnetic minimum
(minimum-B) trap formed by superconducting octupole and mirror magnet coils.
The trapped antiatoms were detected by rapidly turning off these magnets,
thereby eliminating the magnetic minimum and releasing any antiatoms contained
in the trap. Once released, these antiatoms quickly hit the trap wall,
whereupon the positrons and antiprotons in the antiatoms annihilated. The
antiproton annihilations produce easily detected signals; we used these signals
to prove that we trapped antihydrogen. However, our technique could be
confounded by mirror-trapped antiprotons, which would produce
seemingly-identical annihilation signals upon hitting the trap wall. In this
paper, we discuss possible sources of mirror-trapped antiprotons and show that
antihydrogen and antiprotons can be readily distinguished, often with the aid
of applied electric fields, by analyzing the annihilation locations and times.
We further discuss the general properties of antiproton and antihydrogen
trajectories in this magnetic geometry, and reconstruct the antihydrogen energy
distribution from the measured annihilation time history.Comment: 17 figure
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