The platelet activation induced by wheat germ agglutinin

AbstractIn human platelets, wheat germ agglutinin (WGA) induced serotonin release without cell agglutination. WGA induced the phosphorylation of both 40-kDa and 20-kDa proteins in a parallel manner, and at least, the phosphorylation of 40-kDa protein was preceded by transient formation of endogenous diacylglycerol (DG) accompanied by a decrease in phosphatidylinositol (PI). Both phosphorylation of these two proteins and serotonin release were inhibited by prior treatment of platelets with dibutyryl cyclic AMP, W-7, or TMB-8. These results suggest that both phosphatidylinositol turnover and Ca2+ mobilization play an essential role in WGA-induced platelet activation

Inverse Magnetic Susceptibility Fabrics in Pelagic Sediment: Implications for Magnetofossil Abundance and Alignment

金沢大学理工研究域地球社会基盤学系Single-domain magnetite particles exhibit minimum susceptibility along their elongation, resulting in so-called inverse fabric of the anisotropy of magnetic susceptibility (AMS). We report the discovery of inverse AMS fabrics from pelagic clay recovered by a ∼12 m long piston core from the western North Pacific. A previous study identified fossil single-domain magnetite produced by magnetotactic bacteria (magnetofossils) as the dominant ferrimagnetic mineral in the sediment. The inverse AMS fabrics were found in a ∼2 m zone. The ∼6 and ∼4 m of sediment above and below this zone showed normal, horizontal AMS fabrics. Rock magnetic data and ferromagnetic resonance spectroscopy indicated that magnetofossils account for most of the mean susceptibility regardless of normal or inverse AMS. This was explained by the mixing models where the inverse fabric from magnetofossils is nearly balanced by the normal fabrics of terrigenous minerals. The corrected degree of AMS carried by magnetofossils in the sediment was estimated to be ∼1.01, which is comparable to that of typical pelagic sediment at shallow depth. On the other hand, terrigenous minerals in the sediment were estimated to have higher degree of anisotropy, possibly reflecting burial and subsequent erosion of >80 m of sediment, which was also suggested by a subbottom acoustic stratigraphy. This suggests that inverse AMS fabrics due to magnetofossils may be widespread in pelagic clay without strong compaction. ©2019. American Geophysical Union. All Rights Reserved

原発性限局性尿道アミロイドーシスの1例

Amyloidosis of the urethra is a rare disease. The clinical appearance resembles carcinoma of the urethra, so that biopsy is required to make the appropriate diagnosis. Once primary localized amyloidosis of the urethra has been diagnosed, selection of the appropriate treatment for each case becomes important. We report a case of primary localized amyloidosis in the male anterior urethra. This case was treated successfully with urethral dilatation

男性化副腎皮質癌の1例

A 36-year-old woman who had experienced two pregnancies consulted our hospital, because of scant menses and virilization. A 24-hour excretion of 17-ketosteroids and 17-hydroxy-corticosteroids demonstrated a decrease in 11-hydroxylase. A computed tomogram showed a huge inhomogenous tumefaction in the left adrenal. Left selective renal angiography revealed a large adrenal tumefaction. Selective adrenal venous samplings revealed that testosterone and dehydroepiandrosterone (DHA) were produced in response to stimulation by 0.25 mg exogenous adrenocorticotropic hormone (ACTH). After left adrenalectomy was performed, a diagnosis of adrenocortical carcinoma was made by pathological examination. This is the first report of a patient with a virilizing adrenocortical carcinoma, which produced testosterone and DHA in response to exogenous ACTH stimulation