Synthesis, structure, and biological activity of [2.2]paracyclophane derivatives. 8*. α-Pyridyl([2.2]paracyclophan-4-yl)-phenylmethanol: Structure of the complex with Cu(II) chloride and intramolecular cyclization

The reaction of 2-benzoylpyridine with 4-([2.2]paracyclophanyl)lithium or of 4-benzoyl[2.2]paracyclophane with 2-pyridyllithium gave α-pyridyl([2.2] paracyclophan-4- yl)phenylmethanol. X-ray analysis has been used to study the molecular and crystalline structure of its complex with Cu(II) chloride. It was found that this triaryl-substituted methanol undergoes an intramolecular cyclocondensation in refluxing formic acid and involves the pyridine ring and the cyclophane substituent. Heterocyclization at the ortho-position of the latter gives 10-phenyl[2.2]paracyclophano[4,5-b]indolizine and cyclization at the pseudo-gem-position the 1-phenyl-1,1a-dehydro-6-aza[3.2.2](1,2,5)-6H- cyclophano[1,2-a]pyridine. The compounds prepared have luminescent properties. ©2005 Springer Science+Business Media, Inc

Synthesis, structure, and biological activity of [2.2]paracyclophane derivatives. 8*. α-Pyridyl([2.2]paracyclophan-4-yl)-phenylmethanol: Structure of the complex with Cu(II) chloride and intramolecular cyclization

The reaction of 2-benzoylpyridine with 4-([2.2]paracyclophanyl)lithium or of 4-benzoyl[2.2]paracyclophane with 2-pyridyllithium gave α-pyridyl([2.2] paracyclophan-4- yl)phenylmethanol. X-ray analysis has been used to study the molecular and crystalline structure of its complex with Cu(II) chloride. It was found that this triaryl-substituted methanol undergoes an intramolecular cyclocondensation in refluxing formic acid and involves the pyridine ring and the cyclophane substituent. Heterocyclization at the ortho-position of the latter gives 10-phenyl[2.2]paracyclophano[4,5-b]indolizine and cyclization at the pseudo-gem-position the 1-phenyl-1,1a-dehydro-6-aza[3.2.2](1,2,5)-6H- cyclophano[1,2-a]pyridine. The compounds prepared have luminescent properties. ©2005 Springer Science+Business Media, Inc

CLINICAL VALUE OF METFORMIN IN APPLICATION AGAINST DIABETES AND OBESITY IN CHILDREN AND TEENAGERS

The Type 1 and Type 2 diabetes mellitus spread is growing up among children. This article highlights the data on the disease epidemiology, etiology, risk factors of the progression, clinical run and complications. Special attention is paid to the obesity as a condition, which most often accompanies insulin resistance and diabetes formation; the authors consider also prevention opportunities. The tactics of the management of patient with the said pathology is also highlighted here.Key words: diabetes, insulin resistance, disturbed tolerance to glucose, obesity, treatment, children

CLINICAL VALUE OF METFORMIN IN APPLICATION AGAINST DIABETES AND OBESITY IN CHILDREN AND TEENAGERS

The Type 1 and Type 2 diabetes mellitus spread is growing up among children. This article highlights the data on the disease epidemiology, etiology, risk factors of the progression, clinical run and complications. Special attention is paid to the obesity as a condition, which most often accompanies insulin resistance and diabetes formation; the authors consider also prevention opportunities. The tactics of the management of patient with the said pathology is also highlighted here.Key words: diabetes, insulin resistance, disturbed tolerance to glucose, obesity, treatment, children

КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ПРИМЕНЕНИЯ МЕТФОРМИНА ПРИ САХАРНОМ ДИАБЕТЕ И ОЖИРЕНИИ У ДЕТЕЙ И ПОДРОСТКОВ

The Type 1 and Type 2 diabetes mellitus spread is growing up among children. This article highlights the data on the disease epidemiology, etiology, risk factors of the progression, clinical run and complications. Special attention is paid to the obesity as a condition, which most often accompanies insulin resistance and diabetes formation; the authors consider also prevention opportunities. The tactics of the management of patient with the said pathology is also highlighted here.Key words: diabetes, insulin resistance, disturbed tolerance to glucose, obesity, treatment, children.В настоящее время увеличивается частота встречаемости сахарного диабета как первого, так и второго типа среди детского населения. В данной статье приводятся данные по эпидемиологии болезни, этиологии, факторах риска развития, клиническому течению, осложнениях. Особое внимание отводится ожирению, как состоянию, наиболее часто сопровождающему инсулинорезистентность и формирование сахарного диабета; рассматриваются возможности профилактики. Представлена тактика ведения больных с указанной патологией.Ключевые слова: сахарный диабет, инсулинорезистентность, нарушенная толерантность к глюкозе, ожирение, лечение, дети. (Педиатрическая фармакология 2009;6(3):89-96)