Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice

Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose of this study was to determine whether treatment with the antioxidant ubiquinol improves muscle mass, cardiac function, and behavioral measures of fatigue in tumor-bearing mice. Method: Adult female mice were inoculated with colon26 tumor cells. Half the control and tumor-bearing mice were administered ubiquinol (500 mg/kg/day) in their drinking water. Voluntary wheel running (i.e., voluntary running activity [VRA]) and grip strength were measured at Days 0, 8, 14, and 17 of tumor growth. Cardiac function was measured using echocardiography on Day 18 or 19. Biomarkers of inflammation, protein degradation, and oxidative stress were measured in serum and heart and gastrocnemius tissue. Results: VRA and grip strength progressively declined in tumor-bearing mice. Muscle mass and myocardial diastolic function were decreased, and expression of proinflammatory cytokines was increased in serum and muscle and heart tissue on Day 19 of tumor growth. Oxidative stress was present only in the heart, while biomarkers of protein degradation were increased only in the gastrocnemius muscle. Ubiquinol increased muscle mass in the tumor-bearing and control animals but had no effect on the expression of biomarkers of inflammation, protein degradation, or oxidative stress or on behavioral measures of fatigue

INDIVIDUAL INFUSION OF M-HEALTH TECHNOLOGIES: DETERMINANTS AND OUTCOMES

Despite substantial research on IT implementation in the IS field, the healthcare industry has historically been considered a technological laggard and lacks direction for how to successfully infuse new technological innovations within individuals work practices. Theoretically, mobile-health (m-health) technologies, if infused in work practices can potentially enhance the quality of healthcare delivery. The question remains as to whether practitioners\u27 performance significantly improves and individual knowledge is enhanced through the infusion of these technologies. While a significant amount of extant literature focuses on initial technology adoption and acceptance, there remains a dearth of literature in the IS field focusing on the long term utilisation and associated benefits. This paper addresses this gap in extant literature through the development and testing of a conceptual model, exploring determinants of individual infusion of m-health technologies and their subsequent outcomes. This study reveals (a) key enablers of successful mobile infusion in a healthcare context and that successful infusion is determined by the characteristics of the: 1. technology 2. user and 3. task, (b) Infusion of mobile technologies leads to improvements in preventative care, greater decision making and reduced medical errors and, (c) Individuals perceive that knowledge is presented rather than created through mobile technologies

Case report: The obstetric patient going for non-obstetric surgery

Surgical disease during pregnancy is relatively common. Surgical intervention depends on its urgency and priority is given to the mother's health though the surgical treatment poses threat to both mother and foetus Case Summary: A 24-year-old gravida 3 Para 2+0 known asthmatic at a gestational age of 20 weeks was diagnosed of acute appendicitis. General anaesthesia was administered with rapid sequence induction with propofol, endotracheal intubation facilitated with suxamethonium, anaesthesia maintained with pancuronium and halothane. Neuromuscular block was reversed with neostigmine. Operative findings were a ruptured appendix. She had a spontaneous vagina delivery at 36 weeks. Conclusion: Anaesthetic and surgical management of non-obstetric surgery during pregnancy is a challenge especially in developing countries where there is lack of sophisticated equipment

Implementing Electric Consent Aimed at People Living with Dementia and Their Caregivers: Did We Forget Those Who Forget?

As policy flows down from law/regulation (e.g. GDPR) and/or individual privacy concerns give rise to demands on improving accessibility, awareness and comprehension, the topic of electronic consent (or eConsent) is becoming more prevalent. We provide a critical voice by considering, but also challenging, the underlying assumptions that the status quo of eConsent design and implementation is appropriate for all people in society. While on-going efforts are focusing on enhancing the eConsent process, there is still room for improvement. The “one size fits all” ethos is not applicable in every context. This paper makes us aware of the different ethical, legal, social and technical implications of ICT use by senior citizens and provides an opportunity to create discourse in this area. It argues that future research examining the effectiveness of innovative ICTs must take the eConsent process into account

The Status Quo of IS Conference Publications on Theorising eHealth in Developing Countries

The purpose of this systematic review is to consolidate existing evidence on electronic health (eHealth) initiatives examined in developing countries to better inform future practice and research. More specifically, this paper examines the status quo of theorising eHealth in developing countries across a range of top Information Systems (IS) conference publications over a fifteen year period (2000–2015). While some work has been done on examining the application of theory within the eHealth domain, the associated context in which this work is performed is often over looked. Examining the papers from a theoretical and contextual perspective reveal that IS researchers’ primary attention is generalisable theory (in the form of explanation) with some consideration given to the interaction with the healthcare context. IS researchers should leverage the lessons learned from other IS sub domains and move beyond generalisable theories to further enrich the understanding of eHealth in developing countries